Results 241 to 250 of about 71,511,565 (289)

Interleukin-12

BioDrugs, 2003
Asthma is an inflammatory disease of the airways leading to significant morbidity and mortality. With advances in the understanding of the molecular and cellular mechanisms involved in the asthmatic response, researchers have identified specific mediators that may be targeted to control the inflammatory state of asthma. The Th2 hypothesis proposes that
Patricia, Leonard, Sanjiv, Sur
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Interleukin-12 (IL-12)

1995
Abstract cDNAs for human and murine IL-12 subunits have been cloned (Wolf et al. 1991; Gubler et al. 1991; Schoenhaut et al. 1992). The nucleotide sequences of the p40 subunit from man and mouse (GenBank accession numbers M65292, M65272, and M86671) predict polypeptides of 328 and 335 amino acids, respectively.
S F Wolf, E Nickbarg
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The interleukin‐12 subunit p40 specifically inhibits effects of the interleukin‐12 heterodimer

European Journal of Immunology, 1993
AbstractThe recently discovered cytokine interleukin (IL)‐12 is a heterodimeric protein of two disulfide‐bonded subunits of 35 and 40 kDa. IL‐12 has multiple effects on T cells and natural killer (NK) cells. In particular it appears to be a major factor for the development of cellular immunity.
F, Mattner, S, Fischer, S, Guckes, S, Jin, H, Kaulen, E, Schmitt, E, Rüde, T, Germann   +7 more
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Circulating interleukin-10 and interleukin-12 in Parkinson’s disease

Acta Neurologica Scandinavica, 2009
Interleukin (IL)-12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and proliferation of T cells and increases production of proinflammatory cytokines. IL-10 is a pleiotropic cytokine produced by both lymphocytes and mononuclear phagocytes including microglia.
M, Rentzos, C, Nikolaou, E, Andreadou, G P, Paraskevas, A, Rombos, M, Zoga, A, Tsoutsou, F, Boufidou, E, Kapaki, D, Vassilopoulos   +9 more
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Genetic evidence for the existence of interleukin-23 and for variation in the interleukin-12 and interleukin-12 receptor genes in the horse

Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2006
Immune loci, characterized by features reflecting their role in defense reactions and consequently related to evolutionary mechanisms, including polymorphisms or association with disease are suitable candidates for comparative analysis. Interleukin-12 and related cytokines are key molecules regulating natural and specific immune responses.
Petr, Kralik, Jan, Matiasovic, Petr, Horin   +2 more
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Interleukin-12 but not interleukin-18 is associated with severe endometriosis

Fertility and Sterility, 2009
To evaluate interleukin (IL)-12 and IL-18 levels in the serum and peritoneal fluid of women with and without endometriosis.Cross-sectional survey.University hospital.Interleukin-12 and IL-18 levels were compared in 105 patients submitted to laparoscopy because of symptoms suggestive of endometriosis (pain and/or infertility).
Flávia, Fairbanks, Mauricio S, Abrão, Sergio, Podgaec, João Antonio, Dias, Ricardo M, de Oliveira, Luiz Vicente, Rizzo   +5 more
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Interleukin-12 and malaria

Research in Immunology, 1995
J M, Crutcher, M M, Stevenson, M, Sedegah, S L, Hoffman   +3 more
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Interleukin 12 and autoimmune diabetes

Nature Genetics, 2001
Interleukin 12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-obese diabetic (NOD) mouse. Following this lead, a new locus associated with human type 1 diabetes, IDDM18, has been identified near the gene encoding the p40 subunit of interleukin 12 (IL12B).
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Production of interleukin-12

Research in Immunology, 1995
X, Ma, A, D'Andrea, M, Kubin, M, Aste-Amezaga, A, Sartori, J, Monteiro, L, Showe, M, Wysocka, G, Trinchieri   +8 more
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Producer cells of interleukin 12

Parasitology Today, 1993
G, Trinchieri, M, Rengaraju, A, D'Andrea, N M, Valiante, M, Kubin, M, Aste, J, Chehimi   +6 more
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