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Long-Term Follow-Up of Phase I Trial of Oncolytic Adenovirus-Mediated Cytotoxic and Interleukin-12 Gene Therapy for Treatment of Metastatic Pancreatic Cancer. [PDF]
BiomedicinesBhatnagar AR +5 more
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Journal of Leukocyte Biology, 1994
Abstract Interleukin-12 (IL-12) is a newly characterized cytokine that has a unique heterodimeric structure. It was initially cloned from B lymphoblastoid cell lines, but the majority of IL-12 is produced by macrophages/monocytes following appropriate stimulation. IL-12 can (1) enhance the cytolytic activity of a number of effector cells
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Abstract Interleukin-12 (IL-12) is a newly characterized cytokine that has a unique heterodimeric structure. It was initially cloned from B lymphoblastoid cell lines, but the majority of IL-12 is produced by macrophages/monocytes following appropriate stimulation. IL-12 can (1) enhance the cytolytic activity of a number of effector cells
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International Archives of Allergy and Immunology, 1995
Interleukin (IL)-12 was originally identified as a factor produced by human Epstein-Barr virus-transformed B cell lines. It was detected by one group as cytotoxic lymphocyte maturation factor, a cytokine that synergized with IL-2 in the induction of lymphokine-activated killer cells and cytotoxic T lymphocytes.
T, Germann, E, Rüde
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Interleukin (IL)-12 was originally identified as a factor produced by human Epstein-Barr virus-transformed B cell lines. It was detected by one group as cytotoxic lymphocyte maturation factor, a cytokine that synergized with IL-2 in the induction of lymphokine-activated killer cells and cytotoxic T lymphocytes.
T, Germann, E, Rüde
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Immunoregulation by interleukin-12
Journal of Leukocyte Biology, 1996Abstract Interleukin-12 (IL-12) is a heterodimeric cytokine produced primarily by antigen-presenting cells (monocytes, macrophages, dendritic cells, and B cells). Its production is stimulated by bacteria, bacterial products, and intracellular parasites and enhanced by priming with granulocyte-macrophage colony-stimulating factor (CM-CSF)
G, Trinchieri, F, Gerosa
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BioDrugs, 2003
Asthma is an inflammatory disease of the airways leading to significant morbidity and mortality. With advances in the understanding of the molecular and cellular mechanisms involved in the asthmatic response, researchers have identified specific mediators that may be targeted to control the inflammatory state of asthma. The Th2 hypothesis proposes that
Patricia, Leonard, Sanjiv, Sur
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Asthma is an inflammatory disease of the airways leading to significant morbidity and mortality. With advances in the understanding of the molecular and cellular mechanisms involved in the asthmatic response, researchers have identified specific mediators that may be targeted to control the inflammatory state of asthma. The Th2 hypothesis proposes that
Patricia, Leonard, Sanjiv, Sur
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Interleukin-12 and interleukin-16 in periodontal disease
Cytokine, 2005The immune system plays an important role in the pathological process of periodontitis. Interleukin-12 (IL-12) is produced by monocytes, macrophages and neutrophils. These cells are proinflammatory infiltrates in periodontitis tissues. High IL-12 will contribute to the immune reaction to Th1 type. IL-12 is an inducer of INF-r production.
I-San, Tsai +5 more
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Interleukin-12, interleukin-23, and psoriasis: Current prospects
Journal of the American Academy of Dermatology, 2007The clinical phenotype of psoriasis results from infiltration of T cells in the skin and elaboration of inflammatory cytokines. Interleukin (IL)-12 and, more recently, IL-23 have been implicated in the pathogenesis of psoriatic lesions. New therapies, including a monoclonal antibody against a subunit shared by IL-12 and IL-23, have been developed to ...
Dorothea C, Torti, Steven R, Feldman
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1995
Abstract cDNAs for human and murine IL-12 subunits have been cloned (Wolf et al. 1991; Gubler et al. 1991; Schoenhaut et al. 1992). The nucleotide sequences of the p40 subunit from man and mouse (GenBank accession numbers M65292, M65272, and M86671) predict polypeptides of 328 and 335 amino acids, respectively.
S F Wolf, E Nickbarg
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Abstract cDNAs for human and murine IL-12 subunits have been cloned (Wolf et al. 1991; Gubler et al. 1991; Schoenhaut et al. 1992). The nucleotide sequences of the p40 subunit from man and mouse (GenBank accession numbers M65292, M65272, and M86671) predict polypeptides of 328 and 335 amino acids, respectively.
S F Wolf, E Nickbarg
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Molecular characterization of interleukin 12
Archives of Biochemistry and Biophysics, 1992Interleukin 12 (IL-12), formerly known as cytotoxic lymphocyte maturation factor and natural killer cell stimulatory factor, is a cytokine secreted by a human B lymphoblastoid (NC-37) cell line when induced in culture with phorbol ester and calcium ionophore. This factor has been purified to homogeneity and shown to synergize with low concentrations of
F J, Podlaski +8 more
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