Results 341 to 350 of about 986,782 (400)

Interleukin-12 (IL-12)

1995
Abstract cDNAs for human and murine IL-12 subunits have been cloned (Wolf et al. 1991; Gubler et al. 1991; Schoenhaut et al. 1992). The nucleotide sequences of the p40 subunit from man and mouse (GenBank accession numbers M65292, M65272, and M86671) predict polypeptides of 328 and 335 amino acids, respectively.
S F Wolf, E Nickbarg
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Circulating interleukin-10 and interleukin-12 in Parkinson’s disease

Acta Neurologica Scandinavica, 2009
Interleukin (IL)-12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and proliferation of T cells and increases production of proinflammatory cytokines. IL-10 is a pleiotropic cytokine produced by both lymphocytes and mononuclear phagocytes including microglia.
M, Rentzos, C, Nikolaou, E, Andreadou, G P, Paraskevas, A, Rombos, M, Zoga, A, Tsoutsou, F, Boufidou, E, Kapaki, D, Vassilopoulos   +9 more
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Interleukin-12 but not interleukin-18 is associated with severe endometriosis

Fertility and Sterility, 2009
To evaluate interleukin (IL)-12 and IL-18 levels in the serum and peritoneal fluid of women with and without endometriosis.Cross-sectional survey.University hospital.Interleukin-12 and IL-18 levels were compared in 105 patients submitted to laparoscopy because of symptoms suggestive of endometriosis (pain and/or infertility).
Flávia, Fairbanks, Mauricio S, Abrão, Sergio, Podgaec, João Antonio, Dias, Ricardo M, de Oliveira, Luiz Vicente, Rizzo   +5 more
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Interleukin-12, interleukin-23, and psoriasis: Current prospects

Journal of the American Academy of Dermatology, 2007
The clinical phenotype of psoriasis results from infiltration of T cells in the skin and elaboration of inflammatory cytokines. Interleukin (IL)-12 and, more recently, IL-23 have been implicated in the pathogenesis of psoriatic lesions. New therapies, including a monoclonal antibody against a subunit shared by IL-12 and IL-23, have been developed to ...
Dorothea C, Torti, Steven R, Feldman
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Interleukin-12 and the regulation of innate resistance and adaptive immunity

Nature reviews. Immunology, 2003
G. Trinchieri
semanticscholar   +1 more source

Interleukin-12 and malaria

Research in Immunology, 1995
J M, Crutcher, M M, Stevenson, M, Sedegah, S L, Hoffman   +3 more
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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

Nature, 2003
D. Cua, J. Sherlock, Yi Chen, C. Murphy, Barbara Joyce, B. Seymour, L. Lucian, W. To, Sylvia Kwan, T. Churakova, S. Zurawski, M. Wiekowski, S. Lira, D. Gorman, R. Kastelein, J. Sedgwick   +15 more
semanticscholar   +1 more source

Interleukin 12 and autoimmune diabetes

Nature Genetics, 2001
Interleukin 12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-obese diabetic (NOD) mouse. Following this lead, a new locus associated with human type 1 diabetes, IDDM18, has been identified near the gene encoding the p40 subunit of interleukin 12 (IL12B).
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Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.

Annual Review of Immunology, 1995
G. Trinchieri
semanticscholar   +1 more source

Production of interleukin-12

Research in Immunology, 1995
X, Ma, A, D'Andrea, M, Kubin, M, Aste-Amezaga, A, Sartori, J, Monteiro, L, Showe, M, Wysocka, G, Trinchieri   +8 more
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