Results 251 to 260 of about 63,752,558 (296)

The role of interleukin-17 in epilepsy

Epilepsy Research, 2022
Epilepsy is a common neurological disorder that seriously affects human health. It is a chronic central nervous system dysfunction caused by abnormal discharges of neurons. About 50 million patients worldwide are affected by epilepsy. Although epileptic symptoms of most patients are controllable, some patients with refractory epilepsy have no response ...
Jiayin, An, He, Li, Demeng, Xia, Bin, Xu, Jiayan, Wang, Huahui, Qiu, Jiaojiang, He   +6 more
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Interleukin-17 in Inflammatory Myopathies

Current Rheumatology Reports, 2012
Since the identification of interleukin (IL)-17 as a T-cell-derived cytokine 15 years ago, the contribution of the T-helper type 17 (Th17) pathway in inducing and maintaining chronic inflammation has been well-established, particularly in rheumatoid arthritis. In addition to the main Th1 profile first suggested to contribute to inflammatory myopathies,
Anne, Tournadre, Pierre, Miossec
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Interleukin-17 and the interleukin-17 family member network.

Allergy and asthma proceedings, 2004
Interleukin-17 (now known as IL-17A), is a homodimer of two 155 amino acid chains secreted by CD4+ activated memory T cells (CD45+ RO+) and is available as a glycosylated 20- to 30-kDa homodimeric peptide. Human IL-17 shows amino acid sequence identity of 62.5 and 58% to the mouse and rat sequences, respectively.
HUANG SH, FRYDAS S, KEMPURAJ D, BARBACANE, Renato Carmine, GRILLI, Alfredo, BOUCHER W, LETOURNEAU R, MADHAPPAN B, PAPADOPOULOU N, VERNA, Nicola, DE LUTIIS, Maria Anna, IEZZI, Teresa, RICCIONI, Graziano, THEOHARIDES TC, CONTI, Pio   +14 more
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Interleukin-17 family and IL-17 receptors

Cytokine & Growth Factor Reviews, 2003
Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additional members have been identified ...
T A, Moseley, D R, Haudenschild, L, Rose, A H, Reddi   +3 more
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Regulation of Interleukin-17 Production

2016
Innate immunity represents the first line of host defense against extracellular infections. Timely initiation of inflammatory responses to invading pathogens confers host the ability to prevent, restrict, and eliminate microorganisms and further trigger adaptive immunity to provide extended eradication of the pathogens as well as long-term protection ...
Wenjuan, Dong, Xiaojing, Ma
openaire   +2 more sources

Role of interleukin-17 and interleukin-17-induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease

Coronary Artery Disease, 2006
Atherosclerosis is a chronic inflammatory disease and interleukins are considered to play a key role in the chronic vascular inflammatory response that is typical of atherosclerosis. The serum levels of several of these cytokines have been found to positively correlate with coronary arterial disease and its sequelae.The aim of our study was to evaluate
Hashmi, Satwat, Zeng, Qiu Tang
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Interleukin-17 and interleukin-23 in patients with polymyositis and dermatomyositis

Scandinavian Journal of Rheumatology, 2011
To analyse the concentration of interleukin (IL)-17 and IL-23 in serum and ex vivo culture supernatant of peripheral blood mononuclear cells (PBMCs) from patients with polymyositis (PM) and dermatomyositis (DM) compared with healthy controls (HC).Enzyme-linked immunosorbent assay (ELISA) was used to analyse the concentration of IL-17 and IL-23 from 25 ...
H, Shen, L, Xia, J, Lu, W, Xiao
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Interleukin-17 and airway remodelling

Pulmonary Pharmacology & Therapeutics, 2006
Interleukin (IL)-17A is emerging as important in reinforcing innate immunity by orchestrating sustained neutrophilic mobilisation. Even though there are indications of association with specific airway diseases, there is still no final proof that IL-17A plays a truly causative pathogenic role. There is evidence in mice that endogenous IL-17A contributes
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Measurement of Interleukin 17

Current Protocols in Immunology, 2001
AbstractThis unit describes two procedures for measurement of interleukin‐17 (IL‐17). IL‐17 is a pleiotropic proinflammatory cytokine that binds to its ubiquitously expressed receptor, IL‐17R, resulting in the induction of several other cytokines including IL‐6 and IL‐8.
Andriani C. Patera, Jeffrey I. Cohen
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Interleukin-17

American Journal of Respiratory Cell and Molecular Biology, 2003
Jay K. Kolls, Suzanne T. Kanaly, Alistair J. Ramsay   +2 more
openaire   +1 more source