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Interleukin-17 family and IL-17 receptors
Cytokine & Growth Factor Reviews, 2003Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additional members have been identified ...
T A, Moseley +3 more
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Regulation of Interleukin-17 Production
2016Innate immunity represents the first line of host defense against extracellular infections. Timely initiation of inflammatory responses to invading pathogens confers host the ability to prevent, restrict, and eliminate microorganisms and further trigger adaptive immunity to provide extended eradication of the pathogens as well as long-term protection ...
Wenjuan, Dong, Xiaojing, Ma
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Coronary Artery Disease, 2006
Atherosclerosis is a chronic inflammatory disease and interleukins are considered to play a key role in the chronic vascular inflammatory response that is typical of atherosclerosis. The serum levels of several of these cytokines have been found to positively correlate with coronary arterial disease and its sequelae.The aim of our study was to evaluate
Hashmi, Satwat, Zeng, Qiu Tang
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Atherosclerosis is a chronic inflammatory disease and interleukins are considered to play a key role in the chronic vascular inflammatory response that is typical of atherosclerosis. The serum levels of several of these cytokines have been found to positively correlate with coronary arterial disease and its sequelae.The aim of our study was to evaluate
Hashmi, Satwat, Zeng, Qiu Tang
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Interleukin-17 and interleukin-23 in patients with polymyositis and dermatomyositis
Scandinavian Journal of Rheumatology, 2011To analyse the concentration of interleukin (IL)-17 and IL-23 in serum and ex vivo culture supernatant of peripheral blood mononuclear cells (PBMCs) from patients with polymyositis (PM) and dermatomyositis (DM) compared with healthy controls (HC).Enzyme-linked immunosorbent assay (ELISA) was used to analyse the concentration of IL-17 and IL-23 from 25 ...
H, Shen, L, Xia, J, Lu, W, Xiao
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Current Protocols in Immunology, 2001
AbstractThis unit describes two procedures for measurement of interleukin‐17 (IL‐17). IL‐17 is a pleiotropic proinflammatory cytokine that binds to its ubiquitously expressed receptor, IL‐17R, resulting in the induction of several other cytokines including IL‐6 and IL‐8.
Andriani C. Patera, Jeffrey I. Cohen
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AbstractThis unit describes two procedures for measurement of interleukin‐17 (IL‐17). IL‐17 is a pleiotropic proinflammatory cytokine that binds to its ubiquitously expressed receptor, IL‐17R, resulting in the induction of several other cytokines including IL‐6 and IL‐8.
Andriani C. Patera, Jeffrey I. Cohen
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Interleukin-17 and airway remodelling
Pulmonary Pharmacology & Therapeutics, 2006Interleukin (IL)-17A is emerging as important in reinforcing innate immunity by orchestrating sustained neutrophilic mobilisation. Even though there are indications of association with specific airway diseases, there is still no final proof that IL-17A plays a truly causative pathogenic role. There is evidence in mice that endogenous IL-17A contributes
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To Be 17 Again — Anti–Interleukin-17 Treatment for Psoriasis
New England Journal of Medicine, 2012Interleukin-17 is a cytokine that belongs to a family of six members (interleukins 17A through 17F), which bind a total of five receptors (interleukins 17RA through 17RE).1–3 Of these six interleukin-17 cytokines, interleukins 17A and 17F are very homologous and bind the same receptor complex (interleukins 17RA and 17RC).
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American Journal of Respiratory Cell and Molecular Biology, 2003
Jay K. Kolls +2 more
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Jay K. Kolls +2 more
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