Frontiers in Immunology, 2020 Osteoarthritis (OA), which is the most common degenerative joint disorder, has been considered a non-inflammatory disease with abnormal mechanics. Interleukin (IL)-17 is a pleiotropic cytokine involved in inflammatory diseases and their production is ...
H. Na +8 more
semanticscholar +1 more source
A qualitative analysis of a A$β$-monomer model with inflammation processes for Alzheimer's disease [PDF]
arXiv, 2022 We introduce and study a new model for the progression of Alzheimer's disease incorporating the interactions of A$\beta$-monomers, oligomers, microglial cells and interleukins with neurons through different mechanisms such as protein polymerization, inflammation processes and neural stress reactions.
arxiv
Interleukin-17 Inhibits Adult Hippocampal Neurogenesis [PDF]
, 2014 Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17
Gan, Yan +7 more
core +3 more sources
Targeting interleukin-17 receptors
Oncotarget, 2015 During the last decade, increasing evidence suggests a strong association between chronic inflammation and cancer development among different types of cancer. The dysregulation of pro-inflammatory cytokines or their receptors is a common feature observed in many cancers [1]. Cancer cells take advantage of cytokine or cytokine receptor overexpression to
Chun-Kai Huang +2 more
openaire +3 more sources
Population balances in case of crossing characteristic curves: Application to T-cells immune response [PDF]
, 2016 The progression of a cell population where each individual is characterized by the value of an internal variable varying with time (e.g. size, weight, and protein concentration) is typically modeled by a Population Balance Equation, a first order linear hyperbolic partial differential equation.
arxiv +1 more source
Mycophenolic acid suppresses granulopoiesis by inhibition of interleukin-17 production [PDF]
, 2010 Mycophenolic acid is a commonly used immunosuppressant after organ transplantation and in autoimmune diseases; however, myelosuppression is a major complication despite its largely favorable side-effect profile.
Ley, Klaus +2 more
core +1 more source
Regulation of Mouse Learning and Mood by the Anti-Inflammatory Cytokine Interleukin-10 [PDF]
2020. Doctoral dissertation, University of Miami Miller School of
Medicine. University of Miami Research Repository.
https://scholarship.miami.edu/esploro/outputs/991031524489402976 ISBN:
9798698577058, 2023 Major depressive disorder is a widespread mood disorder. One of the most debilitating symptoms patients often experience is cognitive impairment. Recent findings suggest that inflammation is associated with depression and impaired cognition. Pro-inflammatory cytokines are elevated in the blood of depressed patients and impair learning and memory ...
arxiv
B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]
, 2013 We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
A Casadevall +74 more
core +3 more sources
How native state topology affects the folding of Dihydrofolate Reductase and Interleukin-1beta [PDF]
, 2000 The overall structure of the transition state and intermediate ensembles experimentally observed for Dihydrofolate Reductase and Interleukin-1beta can be obtained utilizing simplified models which have almost no energetic frustration. The predictive power of these models suggest that, even for these very large proteins with completely different folding
arxiv +1 more source
Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs : involvement of MAPK and NF-κB pathways [PDF]
, 2014 The terpenoid 17-O-acetylacuminolide (AA) was shown to inhibit the production of several inflammatory mediators. However, the mechanisms by which this compound elicited its anti-inflammatory activity remain to be elucidated.
Achoui, Mouna +5 more
core +1 more source