Results 71 to 80 of about 4,008,604 (402)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia

Journal of Infection in Developing Countries, 2019
Introduction: Immune response to genital Chlamydia trachomatis infection is involved in both immunity and pathology. The cytokine profile during infection has been implicated in the disease outcome, either resolution or severe sequelae.
Alessandra Bua, Sara Cannas, Stefania Zanetti, Paola Molicotti   +3 more
doaj   +1 more source

Induction in myeloid leukemic cells of genes that are expressed in different normal tissues [PDF]

PNAS 101, 16022 (2004), 2005
Using DNA microarray and cluster analysis of expressed genes in a cloned line (M1-t-p53) of myeloid leukemic cells, we have analyzed the expression of genes that are preferentially expressed in different normal tissues. Clustering of 547 highly expressed genes in these leukemic cells showed 38 genes preferentially expressed in normal hematopoietic ...
arxiv   +1 more source

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice [PDF]

, 2012
Commensal bacterial sensing by Toll-like receptors is critical for maintaining intestinal homeostasis, but can lead to colitis in the absence of interleukin-10. Although Toll-like receptors are expressed in multiple cell types in the colon, the cell type(
Flavell, Richard A., Fox, James G., Gagliani, Nicola, Hoshi, Namiko, Iwasaki, Akiko, Medzhitov, Ruslan, Nish, Simone A., Reizis, Boris, Schenten, Dominik, Shen, Zeli, Walther, Zenta   +10 more
core   +1 more source

The Role of Interleukin-17 in Lung Cancer [PDF]

Mediators of Inflammation, 2016
Tumour-associated inflammation is a hallmark of malignant carcinomas, and lung cancer is a typical inflammation-associated carcinoma. Interleukin-17 (IL-17) is an important inflammatory cytokine that plays an important role in chronic inflammatory and autoimmune diseases and in inflammation-associated tumours.
Feng Wu, Juanjuan Xu, Qi Huang, Jieli Han, Limin Duan, Jinshuo Fan, Zhilei Lv, Mengfei Guo, Guorong Hu, Lian Chen, Shuai Zhang, Xiaonan Tao, Wanli Ma, Yang Jin   +13 more
openaire   +4 more sources

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

Expressions of IL-17, IL-21 and IL-23 in the serum of allergic rhinitis patients [PDF]

Journal of Medical Biochemistry, 2011
The present study aimed to investigate the expressions of interleukin-17 (IL-17), IL-21 and IL-23 in the serum of allergic rhinitis (AR) patients and to explore their relationship with special IgE (sFgE) in the serum.
Huang Xuekun, Yang Qintai, Chen Yulian, Peng Li, Zhang Gehua, Yuan Li   +5 more
doaj  

Evaluation of interleukin 17: A polymorphism in patients with visceralleishmaniasis [PDF]

Journal of Analytical Research in Clinical Medicine, 2014
Introduction: Visceral leishmaniasis (VL) is an infectious disease that it has spread in more than 60 countries, in Iran it is caused by Leishmania infantum.
Safar Sadighi, Ahad Bazmany, Zohreh Babaloo, Hamid Amadi   +3 more
doaj   +1 more source

Evaluating the Use of Generalized Dynamic Weighted Ordinary Least Squares for Individualized HIV Treatment Strategies [PDF]

arXiv, 2021
Dynamic treatment regimes (DTR) are a statistical paradigm in precision medicine which aim to optimize patient outcomes by individualizing treatments. At its simplest, a DTR may require only a single decision to be made; this special case is called an individualized treatment rule (ITR) and is often used to maximize short-term rewards.
arxiv  

Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological Activities, and Therapeutic Implications.

Cold Spring Harbor Perspectives in Biology, 2018
The cytokines of the interleukin 17 (IL-17) family play a central role in the control of infections, especially extracellular fungi. Conversely, if unrestrained, these inflammatory cytokines contribute to the pathology of numerous autoimmune and chronic ...
L. Monin, S. Gaffen
semanticscholar   +1 more source