Results 201 to 210 of about 148,492 (237)

Successful treatment of Erdheim-Chester disease by interleukin-1 receptor antagonist protein

Joint Bone Spine, 2014
Erdheim-Chester disease is a rare non-langerhans systemic histiocytosis of unknown origin, associated with bone diseases and severe visceral complications. Therapies have been disappointing. A recombinant form of interleukin-1 receptor antagonist (anakinra) has been used in a few cases when usual treatment fails.
Audrey, Courcoul, Emmanuelle, Vignot, Roland, Chapurlat   +2 more
openaire   +2 more sources

Purification of Human Recombinant Interleukin 1 Receptor Antagonist Proteins uponBacillus subtilisSporulation

Protein Expression and Purification, 1997
Human interleukin 1 receptor antagonist (IL-1ra) and IL-1ra mutants were constitutively expressed in recombinant Bacillus subtilis in endocellular and active form. In order to optimize the purification of the recombinant proteins, a new method has been developed.
G, Maurizi, V, Di Cioccio, G, Macchia, P, Bossù, C, Bizzarri, U, Visconti, D, Boraschi, A, Tagliabue, P, Ruggiero   +8 more
openaire   +2 more sources

Treatment With an Interleukin-1 Receptor Antagonist Protein Prolongs Mouse Islet Allograft Survival

Diabetes, 1993
An interleukin-1 receptor antagonist protein was evaluated with regard to its efficacy in allogeneic and xenogeneic islet transplantation. Alloxan-induced diabetic C57BL/6 (H-2b) mice were transplanted under the kidney capsule with 500 C57BL/Ks (H-2d) mouse islets.
Sandberg, J O, Eizirik, Decio L., Sandler, S, Tracey, D E, Andersson, A.   +4 more
openaire   +2 more sources

The mouse interleukin 1 receptor antagonist protein: gene structure and regulation in vitro

Cytokine, 1994
The interleukin 1 receptor antagonist (IL-1ra) protein is an inhibitor of the pro-inflammatory cytokine interleukin 1. We have sequenced the mouse gene encoding the monocyte form of IL-1ra (IL-1rn) and compared it with the sequence of the human homologue.
K A, Zahedi, C M, Uhlar, M, Rits, A E, Prada, A S, Whitehead   +4 more
openaire   +2 more sources

Recombinant interleukin-1 receptor antagonist protein prevents sensitization and intestinal anaphylaxis in Guinea pigs

Life Sciences, 1993
Recombinant interleukin-1 receptor antagonist protein (rlRAP, 0.5 mg/kg) administered intraperitoneally in guinea pigs one hour before primary and booster parenteral sensitization (1 ml) by cow milk, led to a reduced immunoglobulin E (IgE) production, as displayed by a passive cutaneous anaphylaxis test.
Theodorou, Vassilia, Fioramonti, Jean, Bueno, Lionel   +2 more
openaire   +3 more sources

Sustained intra-cartilage delivery of interleukin-1 receptor antagonist using cationic peptide and protein-based carriers

Osteoarthritis and Cartilage, 2023
Blocking the interleukin-1 (IL-1) catabolic cascade following joint trauma can be achieved using its receptor antagonist, IL-1Ra. However, its clinical translation for osteoarthritis therapy has been unsuccessful due to its rapid joint clearance and lack of targeting and penetration into deep cartilage layers at therapeutic concentrations.
S. Mehta, T.L. Boyer, S. Akhtar, T. He, C. Zhang, A. Vedadghavami, A.G. Bajpayee   +6 more
openaire   +2 more sources

Interleukin-1α and Interleukin-1β Stimulate Adrenocorticotropin Secretion in the Rat through a Similar Hypothalamic Receptor(s): Effects of Interleukin-1 Receptor Antagonist Protein

Neuroendocrinology, 1993
Numerous reports have demonstrated that interleukin-1 beta (IL-1 beta) is a potent secretagogue for adrenocorticotropin (ACTH) and that IL-1 alpha appears to be considerably less efficacious. To clarify apparent differences in the potency of IL-1 alpha vs. -beta on ACTH secretion from a functional perspective, the IL-1 receptor antagonist protein, IRAP,
S G, Matta, K M, Linner, B M, Sharp
openaire   +2 more sources

Characterization of an interleukin 1 receptor antagonist protein released from ultraviolet-irradiated epidermal sheet

Journal of Dermatological Science, 1997
An interleukin 1 (IL-1) inhibitor was detected in the culture supernatant of mouse epidermal sheet which had been irradiated with middle-wavelength ultraviolet (UVB) either in vitro or in vivo. Properties of the IL-1 inhibitor were consistent with those of IL-1 receptor antagonist (IL-1ra), i.e., approximate molecular size of 17 kDa by gel filtration ...
T, Hirao, H, Aoki, H, Ichikawa, Y, Sato
openaire   +2 more sources

Genetic Regulation and Activities of an Interleukin 1 Receptor Antagonist Protein

1993
Publisher Summary The cytokine interleukin 1 (IL-1) plays an important role in the response to infection and injury. IL-1 can have positive effects on events in the immune response, including T, B, and natural killer (NK) cell activation. Glucocorticoids inhibit both the synthesis of IL-1 and its action on glucocorticoid-sensitive IL-1-responsive ...
Donald B. Carter, Ann E. Berger, Daniel E. Tracey   +2 more
openaire   +1 more source

Reduced muscle protein breakdown in septic rats following treatment with interleukin-1 receptor antagonist

International Journal of Biochemistry, 1994
1. The role of interleukin-1 (IL-1) in sepsis-induced muscle proteolysis was assessed by treating septic rats with recombinant IL-1 receptor antagonist (rIL-1ra). 2. In initial experiments, we tested the effectiveness of IL-1ra in preventing muscle proteolysis induced by administration of IL-1. 3.
O, Zamir, W, O'Brien, R, Thompson, D C, Bloedow, J E, Fischer, P O, Hasselgren   +5 more
openaire   +2 more sources