Results 301 to 310 of about 199,768 (345)

Initial crystallographic analysis of a recombinant human interleukin-1 receptor antagonist protein

Acta Crystallographica Section D Biological Crystallography, 1994
We report the crystallization of samples of a recombinant preparation of human interleukin-1 receptor antagonist protein (IRAP) and solution of the crystal structure by isomorphous replacement methods. Crystals were obtained by the hanging-drop vapor-diffusion method at 277 K from solutions of PEG 4000 containing sodium chloride, dithiothreitol and ...
L.L. Clancy, H. M. Einspahr, Barry C. Finzel, D.P. Brunner, A.W. Yem, R.M. Sweet, M.R. Deibel, N.A. Strakalaitis   +7 more
openaire   +4 more sources

HIGH ALTITUDE INCREASES CIRCULATING INTERLEUKIN-6, INTERLEUKIN-1 RECEPTOR ANTAGONIST AND C-REACTIVE PROTEIN

Cytokine, 2000
Hypoxic pulmonary vasoconstriction is associated with but may not be sufficient for the development of high-altitude pulmonary oedema (HAPO). Hypoxia is known to induce an inflammatory response in immune cells and endothelial cells. It has been speculated that hypoxia-induced inflammatory cytokines at high altitude may contribute to the development of ...
Rudolf L. Riepl, K. Tschöp, Gunther Hartmann, Rainald Fischer, Hubert Hautmann, C. Bidlingmaier, Stefan Endres, M. Toepfer, Matthias H. Tschöp   +8 more
openaire   +4 more sources

Generation of a Transgenic Mouse with Lung-specific Overexpression of the Human Interleukin-1 Receptor Antagonist Protein

American Journal of Respiratory Cell and Molecular Biology, 1998
The purpose of the studies described here was to test the hypothesis that overexpression of the human interleukin-1 receptor antagonist (IL-1ra) in the distal airway epithelia of mice would result in amelioration of the inflammatory effects of IL-1alpha.
Robert W. Wilmott, Joseph A. Kitzmiller, Michael A. Fiedler, James M. Stark   +3 more
openaire   +3 more sources

Secondary structure and topology of interleukin-1 receptor antagonist protein determined by heteronuclear three-dimensional NMR spectroscopy

Biochemistry, 1992
Interleukin-1 (IL-1) proteins, such as IL-1 beta, play a key role in immune and inflammatory responses. Interaction of these cytokines with the IL-1 receptor induces a variety of biological changes in neurologic, metabolic, hematologic, and endocrinologic systems.
Brian J. Stockman, David P. Brunner, Melinda Roy, Anthony W. Yem, Martin R. Deibel, Nancy A. Strakalaitis, Terrence A. Scahill, Eldon L. Ulrich   +7 more
openaire   +4 more sources

Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.

Diabetes, 1999
The beta-cells in the pancreatic islets of Langerhans are the targets of autoreactive T-cells and are destroyed in type 1 diabetes. Macrophage-derived interleukin-1beta (IL-1beta) is important in eliciting beta-cell dysfunction and initiating beta-cell ...
N. Giannoukakis, W. Rudert, S. Ghivizzani, Andrea Gambotto, Camillo Ricordi, Massimo Trucco, Paul D. Robbins   +6 more
semanticscholar   +1 more source

The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice.

Arthritis & Rheumatism, 1993
OBJECTIVE To investigate the anti-arthritic effect of recombinant human interleukin-1 receptor antagonist protein (IRAP) in two experimental models of arthritis.
P. Wooley, J. Whalen, Darryl L. Chapman, A. E. Berger, Karen A. Richard, D. G. Aspar, N. D. Staite   +6 more
semanticscholar   +1 more source

The mouse interleukin 1 receptor antagonist protein: gene structure and regulation in vitro

Cytokine, 1994
The interleukin 1 receptor antagonist (IL-1ra) protein is an inhibitor of the pro-inflammatory cytokine interleukin 1. We have sequenced the mouse gene encoding the monocyte form of IL-1ra (IL-1rn) and compared it with the sequence of the human homologue.
Alexander S. Whitehead, Clarissa M. Uhlar, Anne E. Prada, Miriam Rits, Kamyar Zahedi   +4 more
openaire   +3 more sources

Interleukin-1 receptor antagonist prevents sepsis-induced inhibition of protein synthesis

American Journal of Physiology-Endocrinology and Metabolism, 1994
To understand the role of interleukin-1 (IL-1) as a mediator of the sepsis-induced skeletal muscle catabolism, we investigated the effects of a specific IL-1 receptor antagonist (IL-1ra) on skeletal muscle protein metabolism in a rodent model of chronic abdominal sepsis.
Thomas C. Vary, J. Vannice, Kelli Gray, Christine V. Jurasinski, E. Owens, Robert N. Cooney   +5 more
openaire   +2 more sources

Interleukin-1 Receptor Antagonist Protein (IL-1Ra)

2009
T. Theodoridis, J. Kraemer
openaire   +2 more sources

Genetic Regulation and Activities of an Interleukin 1 Receptor Antagonist Protein

1993
Publisher Summary The cytokine interleukin 1 (IL-1) plays an important role in the response to infection and injury. IL-1 can have positive effects on events in the immune response, including T, B, and natural killer (NK) cell activation. Glucocorticoids inhibit both the synthesis of IL-1 and its action on glucocorticoid-sensitive IL-1-responsive ...
Ann E. Berger, Daniel E. Tracey, Donald B. Carter   +2 more
openaire   +2 more sources