Results 171 to 180 of about 848,154 (350)

Progranulin protects against Clostridioides difficile infection by enhancing IL-22 production

Gut Microbes
Enhanced mortality, relapse rates, and increased prevalence of Clostridioides difficile infection (CDI) emphasize the need for better therapies and management approaches.
Jun Huang, Bichen Liu, Yi Liu, Wenxian You, Ping Zhao, Yuhan Liu, Kehan Wang, Xiaofei Lai, Banglao Xu, Ju Cao   +9 more
doaj   +1 more source

The Role of Interleukin-22 and Its Receptor in the Development and Pathogenesis of Experimental Autoimmune Uveitis

, 2016
Ye‐Jin Kim, Tae‐Woo Kim, Yun Seong Park, Eui Man Jeong, Dong‐Sup Lee, In Gyu Kim, Hum Chung, Young‐il Hwang, Wang Jae Lee, Hyeong Gon Yu, Jae Seung Kang   +10 more
openalex   +2 more sources

Eczematous drug eruption in patients with psoriasis under anti‐interleukin‐17A: does interleukin‐22 play a key role? [PDF]

, 2021
Matteo Megna, Giuseppina Caiazzo, Melania Parisi, Angelo Ruggiero, Gianmarco Capasso, Massimo Mascolo, Daniela Russo, Lucia Gallo, Gabriella Fabbrocini, Maddalena Napolitano, Cataldo Patruno   +10 more
openalex   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells. [PDF]

J Exp Med, 2023
Moniruzzaman M, Rahman MA, Wang R, Wong KY, Chen AC, Mueller A, Taylor S, Harding A, Illankoon T, Wiid P, Sajiir H, Schreiber V, Burr LD, McGuckin MA, Phipps S, Hasnain SZ.   +15 more
europepmc   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Interleukin‐22 Directly Activates Myocardial STAT3 (Signal Transducer and Activator of Transcription‐3) Signaling Pathway and Prevents Myocardial Ischemia Reperfusion Injury [PDF]

, 2020
J Takahashi, Mai Yamamoto, Hideo Yasukawa, Shoichiro Nohara, Takanobu Nagata, Koutatsu Shimozono, Toshiyuki Yanai, Tomoko Sasaki, Kota Okabe, Tatsuhiro Shibata, Kazutoshi Mawatari, Tatsuyuki Kakuma, Hiroki Aoki, Yoshihiro Fukumoto   +13 more
openalex   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Interleukin-22 [PDF]

, 2020
openaire   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source