Results 51 to 60 of about 417,438 (262)
Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk [PDF]
, 2011 <p><b>Objective:</b> The goal of this study was to examine the association of the antiinflammatory interleukin-10 (IL-10) with risk of cardiovascular disease (CVD).</p>
<p><b>Methods and Results:</b> In the ...Jukema, J.W., Trompet, S., Sattar, N., David J. Stott, Jukema, J. Wouter, Heather M. Murray, Ian Ford, Ford, I., Welsh, Paul, Anton J.M. de Craen, McInnes, Iain B., Trompet, Stella, Paul Welsh, J. Wouter Jukema, Westendorp, Rudi G.J., McInnes, I.B., Welsh, P., Westendorp, R.G.J., Packard, C.J., Murray, H.M., Craen, A.J.M. de, de Craen, Anton J.M., Rudi G.J. Westendorp, Sattar, Naveed, Stella Trompet, Stott, David J., Naveed Sattar, Ford, Ian, Chris J. Packard, Murray, Heather M., PROSPER Study Grp, Packard, Chris J., Iain B. McInnes, Stott, D.J. +33 morecore +1 more sourceThe Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases
Frontiers in Pharmacology, 2021 Interleukin-38 (IL-38), a new cytokine of interleukin-1 family (IL-1F), is expressed in the human heart, kidney, skin, etc. Recently, new evidence indicated that IL-38 is involved in the process of different autoimmune diseases. Autoimmune diseases are a Miao-miao Han, Xin-rong Yuan, Xiang Shi, Xing-Yu Zhu, Xing-Yu Zhu, Yue Su, Yue Su, De-Kai Xiong, Xing-Min Zhang, Huan Zhou, Huan Zhou, Ji-Nian Wang, Ji-Nian Wang +12 moredoaj +1 more sourceInterleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding [PDF]
, 2009 Background: Atherosclerosis is an inflammatory process that develops in individuals with known risk factors that include hypertension and hyperlipidaemia, influenced by diet.Dower, S., Zoe Brookes, Nicholas J Alp, Francis, Sheila, Steven Dower, David C Crossman, Brookes, Zoe, Francis, S., Shaw, Gary, Shaw, G., Crossman, D.C., Gary Shaw, Sheila Francis, Graham, Delyth, Brookes, Z., Alp, N.J., Crossman, David C., Chamberlain, J., Delyth Graham, Dower, Steven, Graham, D., Xu, A., Janet Chamberlain, Alp, Nicholas J., Xu, Aimin, Chamberlain, Janet +25 morecore +1 more sourceInterleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses
, 2022 S.426-438Different modes of cell death regulate immunity. Whereas necrotic (necroptotic, pyroptotic) cell death triggers inflammation, apoptosis contributes to its resolution. Interleukin-1 (IL-1) family cytokines are key players in this interaction.Putyrski, M., Schlemmer, A., Brüne, B., Wittig, I., Han, Y., Richter, F., Ernst, A., Mora, J., Jung, M., Weigert, A., Frank, A.-C. +10 morecore +1 more sourceCardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist : a Mendelian randomisation analysis [PDF]
, 2015 Funded by: UK Medical Research Council, British Heart Foundation, UK National Institute for Health Research, National Institute for Health Research Cambridge Biomedical Research Centre, European Research Council, and European Commission Framework ...D. F. Easton (7608179), Howson, Joanna M M, Singleton, A, E. Harshfield (7646096), Sanna, Serena, Hall, A.S. (Alistair), Bown, Matthew J, Stefánsson, K., Staley, James R, Dunlop, M., Rasmussen-Torvik, L.J. (Laura), B. G. Nordestgaard (7605362), Langefeld, C.D. (Carl), Grande, P, Sanna, S., Smith, AV, G. F. Mitchell (7646183), Kooner, J.S. (Jaspal S.), Felix, J.F., Gudnasson, Vilmundur, Carrell, D. S., McCarty, Catherine A., D. Crossman (7646276), Hakonarson, Hakon, Franco, O.H., Stefansson, K, Nelson, C.P. (Christopher P.), Walston, J. (Jeremy), Eisen, T. (Timothy), Hofman, A., Crosslin, D.R., Assimes, T, D. T. Bishop (7646264), Stefánsson, Kári, de Bakker, Paul I. W., Gorski, M. (Mathias), Malinowski, J. (Jennifer), G. Tromp (7646132), Li, Yong, Goldschmidt, Hartmut, Y. Wang (473169), M. Sudman (7646219), Ferreira, MA, Crawford, DC, Weidinger, S., T. Kessler (7646111), Nielsen, SF, E. Di Angelantonio (7611773), McCarty, C.A. (Catherine A.), O. Gottesman (7646165), März, Winfried, Gorski, Mathias, Hall, AS, J. R. Staley (7646090), Iles, M.M., Hayward, NK, Hopewell, J. C., Peissig, P.L., Brown, Matthew J., Bevan, S, P. Willeit (7605167), Nordestgaard, B.G., L. A. Lange (7646105), Kessler, Thorsten, Delgado, G.E., Law, M. H., Delgado, G., Franceschini, N. (Nora), Nalls, M.A., Zhang, W., Hopewell, Jemma C., Harshfield, E, Delgado, G. E., Franco, O. H., N. J. Timpson (7608851), Tracy, Russell, Franceschini, N, Delgado, GE, H. Baurecht (7646204), M. de Andrade (7646150), Butterworth, Adam S, Bown, M.J., Polychronakos, C. (Constantin), Kooner, J.S., Schunkert, H, A. F. Baas (7646126), Li, Yunlei, Nalls, M.A. (Michael), N. J. Samani (7591811), Peissig, Peggy L., Bown, MJ, de Andrade, Mariza, Wareham, N.J., Nelson, CP, Scott, Robert A., Li, Y., Nejentsev, S., Allan, JM, M. Gorski (7626956), Evans, D.M. (David M.), Van 'T Hof, F.N.G. (Femke), A. A. S. Majumder (7646297), Erdmann, Jeanette, Samani, N. J., Rader, D.J. (Daniel), Harshfield, E., Houlston, R.S., Delgado, Graciela E., S. S. Verma (7646141), Franke, Andre, E. Zeggini (7632767), Zhang, WH, A. Singleton (7646228), Polychronakos, C, Franke, A, U. Thorsteinsdottir (7606031), S. G. Thompson (7646303), M. F. Keller (7646189), J. P. Bradfield (7646234), de Bakker, Paul I W, Allan, J. M., van 't Hof, Femke N. G., D. Chubb (7646255), Nikpay, Majid, M. A. Brown (1916698), Dehghan, Abbas, J. S. Kooner (7605356), Eisen, T, Chubb, Daniel, Harshfield, Eric, Whiffin, N, Freitag, Daniel, H. S. Markus (7626758), Tomlinson, I.P., Goldschmidt, H, Erdmann, J, Baas, A.F., Lange, Leslie A., Nielsen, S. F., Weidinger, S. (Stephan), Farrall, M. (Martin), Kuivaniemi, Helena, Ganesh, Santhi K., Reilly, Muredach, März, W. (Winfried), Huang, J., C. P. Nelson (7591670), Qu, Liming, Thorsteinsdottir, U, Wood, Angela M., De Andrade, M, Ritchie, M.D., Gottesman, O., Kastrati, A, Young, R. (Robin), J. M. Allan (7646246), Young, R., Müller-Nurasyid, M., van ‘t Hof, Femke N.G., Thorsteinsdottir, U. (Unnur), Psaty, B. M., J. Malinowski (7646147), Mueller-Nurasyid, M, Psaty, B.M. (Bruce), Easton, Douglas F., Hakonarson, H, Burgess, S, Ramond, A. (Anna), Marz, W, Luo, Y. (Yang), Pacheco, Jennifer A., Ritchie, Marylyn D., Carrell, D.S. (David), Howson, Joanna M.M., Ho, W.K., Kathiresan, S. (Sekar), S. A. Lubitz (7646210), Spackman, S, Smith, Nicholas L., Hemminki, Kari, Burgess, Stephen, D. C. Crawford (7646144), S. Nejentsev (7646273), D. Thompson (1262301), S. F. Nielsen (7646099), Bevan, S., Kooner, J. S., van 't Hof, F.N.G., Langefeld, Carl D., Lange, Leslie A, Lubitz, S.A. (Steven), Harris, T.B. (Tamara B.), Thompson, D., Sweeting, M, Iles, MM, Bown, M.J. (Matthew), M. Reilly (7609133), Ho, WK, Houlston, Richard S., Houlston, R. S., Ala-Korpela, M. (Mika), Li, Y. (Yong), Verma, S. S., Gottesman, Omri, A. Parsa (7626662), S. D. Thompson (7646222), Tomlinson, I.P. (Ian), J. Kettunen (7646180), Markus, H. S., Franco, O.H. (Oscar), Baas, A. F., Psaty, Bruce M., Ferreira, Manuel A., Jones, G. T., Grande, Peer, Smith, N.L., Al Shafi Majumder, A. (Abdullah), Law, MH, Wang, YF, S. Spackman (7646087), A. V. Smith (7605131), Hemminki, Kari,, Hall, A. S., Dunlop, Malcolm, Panoutsopoulou, K. (Kalliope), Howson, J. M. M., M. M. Iles (7646261), Allan, J.M., Tybjaerg-Hansen, A. (Anne), J. C. Bis (7625957), Ferreira, M.A., Freitag, DF, Matthew James Bown (7632455), Allan, James M., Jones, G.T., Wang, Y., Y. Li (696089), Franke, A., Parsa, Afshin, Bis, J.C. (Joshua), Hall, Alistair S., Farrall, M, Barbalic, M., Gottesman, R.F. (Rebecca), Hayward, N. K., Crosslin, D. R., van Rij, A., Staley, James R., Collins, F.S. (Francis), Porcu, E., Pacheco, J. A., Wang, Y, Lange, L. A., Henrion, Marc, Keller, MF, Zeggini, E, Crosslin, DR, S. Bevan (7626584), Parsa, A., Franco, Oscar H., Bown, Matthew J., Lange, LA, Bradfield, J.P. (Jonathan), Bottinger, EP, Smith, A.V., Lubitz, S.A., Qu, LM, Erdmann, J. (Jeanette), Angelantonio, E.D. (Emanuele Di), Crossman, D, W. K. Ho (7646081), Franceschini, N., Nalls, M. A., Thompson, S.D. (Susan D.), Wood, Angela M, Nelson, C. P., Keller, M. F., Scott, R.A. (Robert), Mitchell, GF, Langefeld, C.D., Qu, L., Smith, N.L. (Nicholas), Bis, J.C., Samani, N.J., Luo, Yang, Rader, Daniel J., Kathiresan, S, Walston, Jeremy D., Soranzo, N., Butterworth, A.S. (Adam), Crossman, D. (David), Collins, R, Sweeting, M., Porcu, E. (Eleonora), Burgess, S. (Stephen), Watkins, H. (Hugh), Hayward, N.K., Baurecht, H. (Hansjörg), Burgess, S., Markus, HS, Freitag, Daniel F., Iles, M. M., W. Zhang (820655), Rasmussen-Torvik, L.J., Thompson, D. (Deborah), Wood, A.M., Kleber, M.E. (Marcus), Tracy, R.P. (Russell), Bis, Joshua C., Huang, Jie, L. Qu (822458), Collins, R., Farrall, M., Li, Y, Hayward, Nicholas K., Parsa, A, Young, Robin, Easton, D. F., Chubb, D., Kullo, Iftikhar J., B. M. Psaty (7605224), A. S. Hall (7605176), Clarke, R. (Robert), D. Saleheen (7605173), Porcu, Eleonora, Grande, P. (Peer), Zeggini, E. (Eleftheria), Zeng, L, N. Soranzo (7608857), Chambers, J.C., M. Nikpay (7646114), L. J. Rasmussen-Torvik (7646174), J. C. Chambers (7605185), Iles, Mark M., K. Panoutsopoulou (7632989), M. Barbalic (7605845), Mitchell, Gary F., Nordestgaard, BG, Porcu, E, Kaptoge, Stephen, Lange, L.A. (Leslie), Crosslin, David R., Parsa, A. (Afshin), Soranzo, Nicole, Hofman, A. (Albert), Chambers, J.C. (John C.), J. A. Pacheco (7646177), O Reilly, M, Maerz, W, S. Weidinger (7646207), Morgan, G., Whiffin, Nicola, Scott, Robert A, Howson, Joanna M. M., Ganesh, S.K. (Santhi), Ala-Korpela, Mika, Scott, RA, Young, R, Müller-Nurasyid, Martina, Bishop, D.T., Jones, G.T. (Gregory), Crossman, David, H. Kuivaniemi (7646135), Kooner, Jaspal S., Willeit, Peter, de Bakker, Paul I.W., Kooner, JS, Tybjaerg-Hansen, Anne, Wang, Yufei, Nelson, C.P., Nordestgaard, Borge G., S. Baltic (7646198), Thorleifsson, Gudmar, Watkins, Hugh, Harris, T. B., D. S. Carrell (7646171), Thompson, D, F. N. G. van 't Hof (7646123), Malinowski, Jennifer, Walston, J.D., C. Polychronakos (7646231), J. D. Walston (7646291), A. S. Butterworth (7605158), Howson, J.M.M. (Joanna M.M.), Schunkert, Heribert, Saleheen, Danish, van 't Hof, Femke N G, Lange, L.A., Wilkinson, Ian B., Spackman, Sarah, N. J. Wareham (7608962), Baurecht, Hansjörg, Bradfield, Jonathan P., T. Assimes (7646279), Kathiresan, Sekar, Panoutsopoulou, K., Markus, Hugh S., Carrell, DS, Ferreira, M. A., Verma, Shefali S., Ferreira, M.A. (Manuel), Goel, A. (Anuj), M. Sweeting (7646084), van 't Hof, F. N. G., J. Erdmann (7603664), G. Morgan (1390121), Sanna, S. (Serena), Eisen, Timothy, Peissig, P. L., Easton, D.F., Wilkinson, IB, Markus, H.S. (Hugh), Freitag, D., Ramond, A., H. Goldschmidt (5077982), Jones, GT, Morgan, G, G. E. Delgado (7646117), Tromp, G. (Gerard), Luo, Y, Hopewell, J.C., Ligthart, S. (Symen), Panoutsopoulou, Kalliope, McPherson, R., Alam, Dewan S., Thompson, SD, Timpson, N.J., A. Ramond (7646093), Thompson, SG, R. Do (7605920), D. F. Freitag (7605161), Thompson, Simon G., Ritchie, M. D., Rasmussen-Torvik, Laura J., Samani, NJ, Danesh, J, E. Porcu (3354512), I. J. Kullo (7646153), Chowdhury, R., Zeng, L. (Lingyao), Wilkinson, I. B., Goldschmidt, H. (Hartmut), Kathiresan, S., Bottinger, E.P. (Erwin), I. B. Wilkinson (7646186), Kettunen, Johannes, A. van Rij (7646129), T. Eisen (7646243), Thompson, S. G., Nikpay, M., Tybjærg-Hansen, Anne, Sanna, S, D. M. Evans (7624460), de Bakker, P.I.W., S. Ligthart (7646120), Bishop, D. Timothy, Nalls, Mike A., Chubb, D, Baltic, Svetlana, Bishop, DT, Goel, A, Assimes, T.L. (Themistocles), Franco Duran, OH, Qu, L, Mitchell, G.F. (Gary), Chubb, D. (Daniel), Alam, D.S. (Dewan S.), M. H. Law (7646267), M. D. Ritchie (7646138), Müller-Nurasyid, M. (Martina), Thorleifsson, G. (Gudmar), S. Sanna (7609256), Walston, J. D., Eisen, T., Polychronakos, Constantin, Muller-Nurasyid, M, Butterworth, Adam S., Crawford, D. C., Zhang, W, Bishop, D.T. (David Timothy), Evans, DM, Butterworth, AS, Bis, JC, Pacheco, J.A., Nordestgaard, Børge G., Zeng, Lingyao, Goel, Anuj, M. Farrall (6522599), Watkins, H., Hayward, N. (Nick), Felix, JF, M. Dunlop (7596542), A. M. Wood (7642988), Howson, J.M.M., K. Hemminki (7646240), Danesh, J., Grande, P., Langefeld, CD, Thompson, S.G., Hemminki, K., Rasmussen-Torvik, LJ, Keller, Margaux F., Singleton, Andrew, ?, ?, Kleber, M, Saleheen, D, Boettinger, EP, Wood, AM, Kettunen, J. (Johannes), Nikpay, M. (Majid), Crawford, D.C. (Dana), G. Thorleifsson (7606022), Zwart, J-A. (John-Anker), Nikpay, M, Felix, Janine, Keller, M.F., Böttinger, E.P., Thompson, S. D., Hakonarson, H., T. B. Harris (7605353), Ritchie, M.D. (Marylyn D.), Soranzo, N. (Nicole), N. Franceschini (7625954), Weidinger, Stephan, Baurecht, Hansjoerg, Peissig, PL, Staley, J. R., R. A. Scott (2840021), Pacheco, J.A. (Jennifer A.), Felix, J. F., Tracy, R., Brown, MA, Di Angelantonio, E, R. S. Houlston (7646258), Wareham, N.J. (Nick), Bakker, P.I.W. (Paul) de, Crawford, D.C., Lubitz, Steven A., Huang, J, Alam, D. S., Franco, OH, Gudnason, V. (Vilmundur), Kullo, I.J., M. Mueller-Nurasyid (7646213), Do, Ron, Kleber, Marcus, Schunkert, H., Reilly, M.P. (Muredach), Tomlinson, Ian P., Reilly, M, Kessler, T. (Thorsten), Franceschini, Nora, Goel, A., McPherson, R. (Ruth), Ritchie, MD, McCarty, C.A., Qu, L. (Liming), J. M. M. Howson (7646075), D. S. Alam (7646294), N. L. Smith (7646216), Al Shafi Majumder, A., Spackman, S., Erdmann, J., Ligthart, Symen, Reilly, M., Chambers, J. C., E. P. Boettinger (7646162), Law, M.H., Nielsen, Sune F, Felix, Janine F., M. Kleber (7609331), Lund University., Butterworth, A.S., Carrell, David S., Willeit, J. (Johann), Scott, R. A., McPherson, R, Nelson, Christopher P., Sudman, M., Henrion, M, Bevan, Steve, Gudnason, V, Staley, J.R., Malinowski, J., Wang, Y. (Yufei), S. Kathiresan (7606013), Dehghan, A., S. Burgess (4176619), Whiffin, N., Wareham, N. J., Bown, M. J., Wareham, NJ, Kessler, T., Sweeting, M. (Michael), Sudman, Marc, Smith, Albert V., Chambers, John C., Bradfield, J. P., Tybjaerg-Hansen, A, J. C. Hopewell (7605365), Felix, J.F. (Janine), L. Zeng (7646108), Lubitz, SA, M. A. Nalls (7646225), Scott, R.A., Markus, H.S., van Rij, Andre, Samani, N.J. (Nilesh), Harris, TB, Freitag, C.M. (Christine), A. Goel (7602413), Kullo, IJ, Franke, A. (Andre), Wareham, Nicholas J., Saleheen, D., Ramond, A, Kathiresan, Sekhar, Jones, Gregory T, Sweeting, Michael, Ligthart, S., Barbalic, Maja, Collins, Rory, Rader, DJ, Timpson, Nicholas J., Smith, A.V. (Davey), Hofman, Albert, Henrion, M., D. R. Crosslin (7646168), G. T. Jones (7627466), Thompson, Deborah, Ganesh, S.K., Wilkinson, I.B., Evans, David M., Tromp, G, Bruijn, L., Nejentsev, S. (Sergey), Kuivaniemi, H., Majumder, Abdullah Al Shafi, Do, R. (Ron), Nordestgaard, B. G., K. Stefansson (7606001), Gorski, M, Al Shafi Majumder, Abdullah, Kettunen, J, Majumder, AAS, M. Ala-Korpela (3442535), Gottesman, O, Assimes, T., McCarty, C. A., Barbalic, M, R. Clarke (7602407), Rasmussen-Torvik, L. J., Walston, JD, Whiffin, N. (Nicola), Tomlinson, IP, Willeit, P, Evans, D.M., Bruijn, Lucie, Nielsen, S.F., Morgan, G. (Gareth), de Bakker, P. I. W., Gudnason, V., Bis, J. C., Tracy, R, Baurecht, H, Polychronakos, C., Nielsen, S.F. (Sune), Bruijn, L. (Lucie), Böttinger, E. P., Bevan, S. (Steve), Kullo, I. J., De Bakker, PIW, McCarty, CA, Mitchell, G. F., Bishop, D. T., Carrell, D.S., Weidinger, S, Mueller-Nurasyid, Martina, Ala-Korpela, M., Samani, Nilesh J., M. A. Ferreira (7646201), J. Danesh (7605383), Hofman, Bert, Law, M.H. (Matthew H.), Watkins, H, Singleton, A., Huang, J. (Jie), Zhang, W. (Weihua), Mitchell, G.F., Van 't Hof, FNG, Nielsen, Sune F., Thompson, Susan D., Barbalic, M. (maja), Malinowski, J, Majumder, AA, Willeit, P., Soranzo, N, I. P. Tomlinson (7646237), Di Angelantonio, Emanuele, Dehghan, A, Li, Yunlei; id_orcid, Baas, A.F. (Annette), Easton, DF, Luo, Y., Staley, JR, A. Tybjaerg-Hansen (7605182), Kaptoge, S., Smith, N. L., Baurecht, H., Kleber, M., Hemminki, K, Zeggini, Eleftheria, Hemminki, K. (Kari), Dunlop, M, Sudman, M. (Marc), Kuivaniemi, H, Angelantonio, Emanuele Di, A. Dehghan (7626011), Brown, M.A. (Matthew), Ho, Weang Kee, Keller, M.F. (Margaux), Kaptoge, S, Baas, Annette F., Henrion, M. (Marc), Kessler, T, Rij, A.M. (Andre) van, Staley, J.R. (James R.), Peissig, P.L. (Peggy L.), Harris, T.B., Chowdhury, Rajiv, M. Henrion (7646249), Clarke, Robert, Chambers, JC, Ramond, Anna, Andrade, M. (Mariza) de, Baltic, S, Boettinger, Erwin P., Alam, D.S., L. Bruijn (7646195), Nejentsev, Sergey, Baltic, S. (Svetlana), Clarke, R., Thorsteinsdottir, Unnur, Kuivaniemi, H. (Helena), Chowdhury, R. (Rajiv), de Andrade, M., Angelantonio, E. D., W. Maerz (7646285), Kullo, I. (Iftikhar), Crossman, D., Hakonarson, H. (Hakon), Wilkinson, I.B. (Ian B.), Tromp, G., Ligthart, S, H. Schunkert (7603670), Tromp, Gerard, S. Kaptoge (7605374), Dunlop, M. (Malcolm), Gorski, M., Böttinger, Erwin P., Pacheco, JA, Harris, Tamara B., P. I. W. de Bakker (7605305), Timpson, N. J., Crosslin, D.R. (David), Bradfield, J.P., Thorleifsson, G, Timpson, NJ, Law, Matthew H., Nordestgaard, B.G. (Børge), Gudnason, Vilmundur, Bradfield, JP, H. Hakonarson (7609127), N. K. Hayward (7646270), Goldschmidt, H., Singleon, Andrew, P. Grande (7646102), Farrall, Martin, Wood, A. M., V. Gudnason (7605347), Crawford, Dana C., Do, R, Verma, S.S., Houlston, RS, Morgan, Gareth, Singleton, A. (Andrew), J. F. Felix (7625948), R. Collins (7159586), Zeng, LY, Clarke, R, Thompson, S.D., A. Franke (7412741), Dehghan, A. (Abbas), Van Rij, A, Smith, A. V., Rader, D.J., Panoutsopoulou, K, Tybjærg-Hansen, A., Bruijn, L, Nalls, MA, Kastrati, Adnan, S. K. Ganesh (7626842), Angelantonio, E.D., Baltic, S., R. Tracy (7646282), Danesh, John, A. Kastrati (7646288), Thorsteinsdottir, U., Easton, D.F. (Douglas), Harshfield, E. (Eric), Kastrati, A. (Adnan), Verma, SS, Zeng, L., März, W., Howson, JMM, Thorleifsson, G., Iles, M.M. (Mark M.), R. McPherson (7605974), Spackman, S. (Sarah), Do, R., Rader, D. J., D. J. Rader (7605215), R. Chowdhury (7646300), Danesh, J. (John), R. Young (7646078), P. L. Peissig (7646156), Brown, Matthew A., Psaty, BM, Verma, S.S. (Shefali S.), Zeggini, E., Schunkert, H. (Heribert), Thompson, S.G. (Simon), McPherson, Ruth, Chowdhury, R, J. Huang (2342368), Jones, Gregory T., Smith, NL, Psaty, B.M., Assimes, Themistocles, Zhang, Weihua, O. H. Franco (7625993), Brown, M.A., Hofman, A, A. Hofman (4269889), Hopewell, Jemma C, H. Watkins (7602419), Kastrati, A., Hall, A.S., Wood, A.M. (Angela), Ala-Korpela, M, C. D. Langefeld (7646192), Ho, W. K., Ganesh, S. K., Lubitz, S. A., Hopewell, JC, Nejentsev, S, Y. Luo (1398985), Maerz, Winfried, Baas, AF, C. A. McCarty (7646159), N. Whiffin (7646252), Hopewell, J., Houlston, R. (Richard), Timpson, N.J. (Nicholas), Allan, J.M. (James), Alam, DS, Kaptoge, S. (Stephen), Delgado, Graciela E, Ho, W.K. (Weang Kee), Sudman, M, Thorsteindottir, Unnur, Kettunen, J., Langefeld, C. D., Tomlinson, I. P., Ganesh, SK +874 morecore +1 more sourceEstablishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns +10 morewiley +1 more sourceHijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...Gabriela Marinescu, Yi Fengwiley +1 more source
