Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages [PDF]
, 2018 open11noSeveral studies suggest that curcumin and related compounds possess antioxidant and anti-inflammatory properties including modulation of lipopolysaccharide- (LPS-) mediated signalling in macrophage cell models. We here investigated the effects of
core +1 more source
Indicators of cytokines in children with hepatobiliary pathology combined with parasitosis
Gastroenterologìa, 2018 Background. Hepatobiliary pathology (HBP) in children tend to continual growth, and the pathology itself is characterized by a group of features that are absent in adults.
T.V. Sorokman +2 more
doaj +3 more sources
The Intriguing Role of Interleukin 13 in the Pathophysiology of Asthma
Frontiers in Pharmacology, 2019 Approximately 5–10% of asthmatic patients worldwide suffer from severe asthma. Experimental and clinical studies have demonstrated that IL-13 is an important cytokine in chronic airways inflammation.
Giancarlo Marone +14 more
doaj +1 more source
Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism
Frontiers in Molecular Neuroscience, 2020 Epilepsy is a chronic brain dysfunction induced by an abnormal neuronal discharge that is caused by complicated psychopathologies. Recently, accumulating studies have revealed a close relationship between inflammation and epilepsy.
Lu Chen +7 more
doaj +1 more source
Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis [PDF]
Osteoarthritis and Cartilage, 2010 IL-13/IL-4/IL-4R system has strong chondroprotective activity. We investigated polymorphisms in these genes as potential hand osteoarthritis (OA) susceptibility loci by performing a case-control association study.Eighteen common single nucleotide polymorphisms (SNPs) (nine in IL-4R, five in IL-4 and four in IL-13) were genotyped in 403 patients (380 ...
Vargiolu M. +11 more
openaire +4 more sources
Immune response to Leishmania (Leishmania) chagasi infection is reduced in malnourished BALB/c mice
Memorias do Instituto Oswaldo Cruz, 2010 Protein-energy malnutrition and micronutrient deficiencies may down-regulate immune response and increase morbidity and mortality due to infection. In this study, a murine model was used to study the effects of protein, iron and zinc deficiencies on the ...
Tiago Donatelli Serafim +4 more
doaj +1 more source
Functional Haplotypes in Interleukin 4 Gene Associated with Periodontitis. [PDF]
PLoS ONE, 2017 Chronic periodontitis (CP) is an infectious inflammatory disease that affects tooth-supporting structures and in which dental plaque bacteria, immune mechanisms and genetic predisposition play important roles.
Giovana Anovazzi +6 more
doaj +1 more source
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites [PDF]
, 2016 Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T ...
Acevedo-Suárez +59 more
core +2 more sources
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020 Our research focused on the role of immune mechanisms in diabetic foot ulcers development and impaired healing. A 3D skin culture system, as a relevant skin model, has proved valuable in investigating these mechanisms and is a useful tool to study ...
Mashkova M. A. +2 more
doaj +1 more source
THE CHANGES IN THE LEVEL OF BETA ENDORPHIN, INTERSLEUKIN-2, INTERLEUKIN-4, INTERLEUKIN-6, IMUNOGLOBULIN AND CORTISOL HORMONE ON THE PRACTICES OF SATRIA NUSANTARA [PDF]
, 2010 The purpose of this research is to reveal the changes of immunity at breathing exercises. This is an experimental research study. This research used “randomized pretest-posttest control group design.
Sudarko, Rumpis Agus
core