Results 21 to 30 of about 695,253 (255)

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11

Frontiers in Immunology, 2020
Cytokines are small signaling proteins that have central roles in inflammation and cell survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty cytokines have been identified. Amongst these is interleukin (IL)
Riley D. Metcalfe, Tracy L. Putoczki, Tracy L. Putoczki, Michael D. W. Griffin   +3 more
doaj   +1 more source

Association of Interleukin 6 Gene Variant and Interleukin 6 level in Children with Congenital Heart Diseases: Single Center Case – Control Study [PDF]

Pediatric Sciences Journal
Background: Etiology of most congenital heart diseases (CHDs) is multifactorial, they include genetic and environmental factors. Interleukin-6 (IL-6) gene variant rs1800795 was reported to be associated with CHD among Chinese children.
Hala Ashraf, Noha Bagdadi, Ahmed Said Behairy, Mahmoud Osman , Heba H. Zeid   +4 more
doaj   +1 more source

Serum levels of interleukin-6 and interleukin-8 as diagnostic markers of acute pyelonephritis in children [PDF]

Korean Journal of Pediatrics, 2013
PurposeEarly diagnosis and treatment of acute pyelonephritis in children is of special importance in order to prevent serious complications. This study was conducted to determine the diagnostic value of serum interleukin (IL)-6 and IL-8 in children with ...
Abolfazl Mahyar, Parviz Ayazi, Mohammad Reza Maleki, Mohammad Mahdi Daneshi-Kohan, Hamid Reza Sarokhani, Hassan Jahani Hashemi, Mousa Talebi-Bakhshayesh   +6 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Targeting IL-6 Receptor Signaling with Satralizumab in Thyroid Eye Disease: Design of the Phase 3 SatraGO-1 and SatraGO-2 Trials

Ophthalmology and Therapy
Introduction Thyroid eye disease (TED) is a rare, autoimmune, orbital inflammatory disorder that is disfiguring, debilitating, and potentially sight-threatening.
Daniel Ezra, Atif Collins, Zdenka Haskova, Thomas Kuenzel, Hiroaki Ida, Miriam Triyatni, Christopher Brittain, Oluwatobi Idowu   +7 more
doaj   +1 more source

Serum interleukin 6 concentration in patients with pemphigus

Dermatology Reports
Pemphigus is a rare autoimmune blistering disease that detrimentally affects the integumentary system and decreases patients’ quality of life. Recent studies have shown that interleukin 6 (IL-6) is closedly involved in the immunophathogenesis of ...
Thai Van Thanh Le, Anh Tuan Ngo, Quoc Hung Ta, The Bich Thanh Vuong   +3 more
doaj   +1 more source

Criteria for the optimal use of interleukin-6 receptor blockers in patients with COVID-19

Терапевтический архив, 2021
Aim. To determine the criteria for the optimal use of IL-6 receptor blockers in patients with COVID-19 community-acquired pneumonia based on predictors of adverse outcomes. Materials and methods.
Tatyana S. Kruglova, Darya S. Fomina, Nataliya G. Poteshkina, Nadija F. Frolova, Irina P. Beloglazova, Zinaida Yu. Mutovina, Inna V. Samsonova, Elena A. Kovalevskaja, Alena I. Zagrebneva, Sofya A. Serdotetckova, Anton A. Chernov, Maryana A. Lysenko   +11 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Recombinant production of human interleukin 6 in Escherichia coli. [PDF]

PLoS ONE, 2013
In this study, we compared basic expression approaches for the efficient expression of bioactive recombinant human interleukin-6 (IL6), as an example for a difficult-to-express protein. We tested these approaches in a laboratory scale in order to pioneer
Henrik Nausch, Jana Huckauf, Roswitha Koslowski, Udo Meyer, Inge Broer, Heike Mikschofsky   +5 more
doaj   +1 more source