Results 71 to 80 of about 7,238,552 (398)

High Levels of Circulating IL-8 and Soluble IL-2R Are Associated With Prolonged Illness in Patients With Severe COVID-19

Frontiers in Immunology, 2021
ObjectivesThe coordinated immune response of the host is the key of the successful combat of the body against SARS-CoV-2 infection and is decisive for the development and progression of COVID-19.
Aiping Ma, Liang Zhang, Xiaokai Ye, Jing Chen, Jie Yu, Liangjin Zhuang, Chaohang Weng, Frank Petersen, Zhanxiang Wang, Xinhua Yu   +9 more
doaj   +1 more source

The tumor-promoting functions of Ataxia-telangiectasia mutated (ATM) in cancer cells [PDF]

, 2015
textAtaxia-telangiectasia mutated (ATM) protein kinase regulates the DNA damage response (DDR) and is associated with cancer suppression by protecting cells from DNA double-strand breaks (DSBs). However, how ATM functions outside of DSB signaling is less
Chen, Wei-Ta, active 21st century
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Interleukin-10 inhibits interleukin-8 production in human neutrophils [PDF]

Blood, 1994
In highly purified human polymorphonuclear leukocyte (PMN) preparations containing less than 0.1% contaminating monocytes, significant amounts of interleukin-8 (IL-8) and small amounts of IL-1 alpha, IL-1 beta, and tumor necrosis factor-alpha (TNF-alpha) were produced by lipopolysaccharide (LPS) stimulation.
P, Wang, P, Wu, J C, Anthes, M I, Siegel, R W, Egan, M M, Billah   +5 more
openaire   +3 more sources

Linked CSF reduction of phosphorylated tau and IL-8 in HIV associated neurocognitive disorder. [PDF]

, 2019
HIV-associated neurocognitive disorder (HAND) is a common condition in both developed and developing nations, but its cause is largely unknown. Previous research has inconsistently linked Alzheimer's disease (AD), viral burden, and inflammation to the ...
Anderson, Albert M, Christina Howell, J, Franklin, Donald, Hu, William T, Kollhoff, Alexander, Letendre, Scott, Loring, David W, Ozturk, Tugba, Tyor, William R, Waldrop-Valverde, Drenna   +9 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease

Brazilian Journal of Medical and Biological Research, 2001
Sickle cell disease has a worldwide distribution and is a public health problem in Brazil. Although vaso-occlusive crisis (VOC) is one of the most important clinical features of the disease, there are still several steps of its pathogenesis which are ...
M.S. Gonçalves, I.L. Queiroz, S.A. Cardoso, A. Zanetti, A.C. Strapazoni, E. Adorno, A. Albuquerque, A. Sant'Ana, M.G. dos Reis, A. Barral, M. Barral Netto   +10 more
doaj   +1 more source

Porcine epidemic diarrhea virus N protein prolongs S-phase cell cycle, induces endoplasmic reticulum stress, and up-regulates interleukin-8 expression

Veterinary Microbiology, 2013
Porcine epidemic diarrhea (PED) is an acute and highly contagious enteric disease of swine caused by porcine epidemic diarrhea virus (PEDV). The porcine intestinal epithelial cell is the PEDV target cell.
Xingang Xu, Honglei Zhang, Qi Zhang, Yong Huang, Jie Dong, Yabing Liang, Hung-Jen Liu, D. Tong   +7 more
semanticscholar   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Determination of Cytokine Levels in Joint Fluid as an Alternative Option for Examination of Internal Temporomandibular Joint Disorders

Česká Stomatologie a Praktické Zubní Lékařství, 2011
Cytokines are extracellular peptides that mediate the strong stimulatory or inhibitory effects on most biological cells. Originally they were considered as candidates for supporting processes of the immune response. It is now clear that they are involved
P. Tvrdý, P. Heinz, L. Hrdina, A. Galandáková, J. Pazdera   +4 more
doaj   +1 more source