Frontiers in Pharmacology, 2023 Introduction: Diabetic nephropathy (DN), a chronic kidney disease, is a major cause of end-stage kidney disease worldwide. Mesenchymal stem cells (MSCs) have become a promising option to mitigate several diabetic complications.Methods: In this study, we ...
Tarek Khamis +33 more
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Homologous Recombination under the Single-Molecule Fluorescence Microscope [PDF]
, 2019 Homologous recombination (HR) is a complex biological process and is central to meiosis and for repair of DNA double-strand breaks. Although the HR process has been the subject of intensive study for more than three decades, the complex protein–protein ...
Dhakal, Soma, Gibbs, Dalton R.
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Epithelial Intermediate Filaments: Guardians against Microbial Infection?
Cells, 2016 Intermediate filaments are abundant cytoskeletal components of epithelial tissues. They have been implicated in overall stress protection. A hitherto poorly investigated area of research is the function of intermediate filaments as a barrier to microbial
Florian Geisler, Rudolf E. Leube
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Role of the gp85/trans-sialidases in Trypanosoma cruzi tissue tropism: preferential binding of a conserved peptide motif to the vasculature in vivo. [PDF]
PLoS Neglected Tropical Diseases, 2010 BACKGROUND: Transmitted by blood-sucking insects, the unicellular parasite Trypanosoma cruzi is the causative agent of Chagas' disease, a malady manifested in a variety of symptoms from heart disease to digestive and urinary tract dysfunctions.
Renata R Tonelli +9 more
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Role of Intermediate Filaments in Blood–Brain Barrier in Health and Disease
Cells, 2021 The blood–brain barrier (BBB) is a highly selective cellular monolayer unique to the microvasculature of the central nervous system (CNS), and it mediates the communication of the CNS with the rest of the body by regulating the passage of molecules into ...
Ece Bayir, Aylin Sendemir
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Keratin 76 is required for tight junction function and maintenance of the skin barrier. [PDF]
PLoS Genetics, 2014 Keratins are cytoskeletal intermediate filament proteins that are increasingly being recognised for their diverse cellular functions. Here we report the consequences of germ line inactivation of Keratin 76 (Krt76) in mice.
Tia DiTommaso +6 more
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Immunohistochemical expression of intermediate filaments in diagnostics of diffuse gliomas.
Medičnì Perspektivi, 2017 Intermediate filament proteins play an important role in maintaining a stable shape, as well as the possible movement of cells, including neoplastic cells.
T. V. Shynkarenko
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Nonlinear Elasticity in Biological Gels [PDF]
, 2004 Unlike most synthetic materials, biological materials often stiffen as they are deformed. This nonlinear elastic response, critical for the physiological function of some tissues, has been documented since at least the 19th century, but the molecular ...
AD Karakaplan +33 more
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Preparation of nuclear matrices from cultured cells: subfractionation of nuclei in situ [PDF]
, 1984 Analyses of the different structural systems of the nucleus and the proteins associated with them pose many problems. Because these systems are largely overlapping, in situ localization studies that preserve the in vivo location of proteins and cellular ...
Deppert, Wolfgang, Staufenbiel, Matthias
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Compartmentalisation and localisation of the translation initiation factor (eIF) 4F complex in normally growing fibroblasts [PDF]
, 2006 Previous observations of association of mRNAs and ribosomes with subcellular structures highlight the importance of localised translation. However, little is known regarding associations between eukaryotic translation initiation factors and cellular ...
Barbarese +82 more
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