Results 101 to 110 of about 57,607 (282)

Interneuron progenitor transplantation to treat CNS dysfunction

Frontiers in Neural Circuits, 2016
Due to the inadequacy of endogenous repair mechanisms diseases of the nervous system remain a major challenge to scientists and clinicians. Stem cell based therapy is an exciting and viable strategy that has been shown to ameliorate or even reverse ...
Muhammad O Chohan, Muhammad O Chohan, Holly Moore, Holly Moore   +3 more
doaj   +1 more source

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source

Defining cis-regulatory elements and transcription factors that control human cortical interneuron development

iScience
Summary: Although human cortical interneurons (cINs) are a minority population in the cerebral cortex, disruption of interneuron development is a frequent contributor to neurodevelopmental disorders. Here, we utilized a model for deriving cINs from human
Gareth Chapman, Julianna Determan, Haley Jetter, Komal Kaushik, Ramachandran Prakasam, Kristen L. Kroll   +5 more
doaj   +1 more source

Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function

Cell Reports, 2019
Summary: Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the
Emily Ling-Lin Pai, Daniel Vogt, Alexandra Clemente-Perez, Gabriel L. McKinsey, Frances S. Cho, Jia Sheng Hu, Matt Wimer, Anirban Paul, Siavash Fazel Darbandi, Ramon Pla, Tomasz J. Nowakowski, Lisa V. Goodrich, Jeanne T. Paz, John L.R. Rubenstein   +13 more
doaj   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Output of neurogliaform cells to various neuron types in the human and rat cerebral cortex

Frontiers in Neural Circuits, 2007
Neurogliaform cells in the rat elicit combined GABAA and GABAB receptor-mediated postsynaptic responses on cortical pyramidal cells and establish electrical synapses with various interneuron types.
Szabolcs Oláh, Gergely Komlósi, János Szabadics, Csaba Varga, Éva Tóth, Pál Barzó, Gábor Tamás   +6 more
doaj   +1 more source

Functional Segregation of Epileptogenicity within the Human Amygdala

Annals of Neurology, EarlyView.
Objective In temporal lobe epilepsy (TLE), the amygdala in the epileptogenic network is underestimated compared to other regions such as the hippocampus. Recent advances in anatomical neuroimaging and stereoelectroencephalography (SEEG) signal analyses could help better understand the involvement of the different amygdala nuclei in the genesis of ...
Odile Feys, Julia Makhalova, Samuel Medina Villalon, Maria Fratello, Hugo Dary, Stanislas Lagarde, Francesca Pizzo, Agnès Trébuchon, Maxime Guye, Jean‐Philippe Ranjeva, Romain Carron, Didier Scavarda, Christian‐George Bénar, Bernard Giusiano, Fabrice Bartolomei   +14 more
wiley   +1 more source

Temporal Dynamics of Binocular Disparity Processing with Corticogeniculate Interactions [PDF]

, 1999
A neural model is developed to probe how corticogeniculate feedback may contribute to the dynamics of binocular vision. Feedforward and feedback interactions among retinal, lateral geniculate, and cortical simple and complex cells are used to simulate ...
Grossberg, Stephen, Grunewald, Alexander
core   +1 more source

Reticulospinal inhibition of interneurones

The Journal of Physiology, 1968
1. The effect of electrical stimulation of the brain stem on interneurones in the dorsal horn and intermediary region has been investigated in decerebrate cats after partial transection of the spinal cord.2. Stimuli that effectively depress reflex transmission without giving a primary afferent depolarization inhibit the discharge evoked from the flexor
I, Engberg, A, Lundberg, R W, Ryall
openaire   +3 more sources

Nanomaterial‐Mediated Near‐Infrared Photothermal Neuromodulation for Neurologic Disorders

Advanced NanoBiomed Research, EarlyView.
This review summarizes how near‐infrared light activates photothermal nanomaterials to enable noninvasive neuromodulation with high spatiotemporal precision. It elucidates the underlying mechanisms, explores targeted therapeutic applications for neurological disorders, discusses integration with optogenetics and biosensors, and addresses future ...
Ting‐Ting Zeng, Yu‐Ge Wang, Ya‐Bing Zhang, Yuan‐Xin Bai, Si‐Tong Lin, Ting‐Ting Zhu, Yan‐Bo Zhou, Wei‐Tong Pan, Pan‐Miao Liu, Jian‐Jun Yang   +9 more
wiley   +1 more source