Encapsulation and Controlled Release of Human Spinal Cord Organoid-Derived Extracellular Vesicles for Tissue Patterning in Viscoelastic Hyaluronic Acid Hydrogels. [PDF]
Adv Healthc MaterChen X +8 more
europepmc +1 more source
Acta Physiologica, Volume 242, Issue 10, October 2026.ABSTRACT The cardiovascular response to acute exercise is mediated by the autonomic nervous system (ANS) control mechanisms that modulate vascular resistance to support blood pressure and ensure adequate blood flow to active muscles. These autonomic neurocirculatory control mechanisms include a feedforward mechanism, known as central command, and three
Rasmus Kopp Hansen +5 more
wiley +1 more source
ASD mutations in the ciliary gene CEP41 impact development of projection neurons and interneurons in a human cortical organoid model. [PDF]
Mol PsychiatryHasenpusch-Theil K +7 more
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 19, Page 5832-5853, October 2026.Serotonin differentially modulates layer 5 mPFC microcircuits through cell type‐specific pre‐ and postsynaptic receptor pathways. Presynaptic 5‐HT1BRs suppress glutamate and GABA release, whereas presynaptic and postsynaptic 5‐HT3ARs enhance fast‐spiking interneuron activity, whilst distinct pyramidal neuron subtypes exhibit divergent 5‐HT1AR‐ and 5 ...
Ramya Rama +4 more
wiley +1 more source
Layer 1 NDNF interneurons modulate thalamocortical input to the auditory cortex. [PDF]
iScienceTao J +5 more
europepmc +1 more source
Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm
British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley +1 more source
Impaired dynein function preserves spinal interneuron survival and positioning in an ALS-like mouse model. [PDF]
PLoS OneChristoforidou E +6 more
europepmc +1 more source
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.Although purinergic P2Y2 receptor can regulate neural stem cell (NSC) proliferation and neurogenesis in mammals, it is downregulated following spinal cord injury (SCI). It was previously unknown whether this receptor regulates these processes in the more‐regenerative zebrafish model, where the contribution of these responses allows near‐complete ...
Isaac J. Sullivan +7 more
wiley +1 more source
Stem cell-based therapeutics in epilepsy: current advances and future prospects. [PDF]
Stem Cells Transl MedPutthanbut N, Lee JY, Borlongan CV.
europepmc +1 more source
A Four‐Terminal TiO2−x Memristor Architecture Enabling Multidimensional Associative Learning
physica status solidi (a), Volume 223, Issue 17, 9 September 2026.This work demonstrates bidirectional Pavlovian conditioning in a single four‐terminal TiO2−x memristor device where two‐dimensional oxygen vacancy control and non‐filamentary resistive switching are realized. Extending this approach, multiple memristors arranged in an array autonomously perform multidimensional associative learning of two‐dimensional ...
Ryohei Yamamoto +4 more
wiley +1 more source