Results 141 to 150 of about 31,985 (192)

Nanotechnology-Enhanced Pharmacotherapy for Intervertebral Disc Degeneration Treatment. [PDF]

Int J Nanomedicine
Shi S, Ou X, Liu C, Li R, Zheng Q, Hu L.
europepmc   +1 more source

The Role of Adipokines in Spinal Disease: A Narrative Review

JOR SPINE, Volume 8, Issue 2, June 2025.
Adipokines, bioactive molecules secreted by adipose tissue, play a key role in both physiological regulation and disease pathogenesis. While their involvement in various organ systems is well documented, their role in spinal pathology remains underexplored.
Jake M. McDonnell, Stacey Darwish, Joseph S. Butler, Conor T. Buckley   +3 more
wiley   +1 more source

NOXA exacerbates endoplasmic-reticulum-stress-induced intervertebral disc degeneration by activating apoptosis and ECM degradation. [PDF]

Cell Death Discov
Liu Z, Lu H, Zhang X, Tang S, Lin A, Han S, Ma X.   +6 more
europepmc   +1 more source

Intradiscal Mesenchymal Stromal Cell Therapy for the Treatment of Low Back Pain Due to Moderate‐to‐Advanced Multilevel Disc Degeneration: A Preliminary Report of a Double‐Blind, Phase IIB Randomized Clinical Trial (DREAM Study)

JOR SPINE, Volume 8, Issue 2, June 2025.
This phase IIB randomized controlled trial evaluated the safety and efficacy of intradiscal injections of autologous bone marrow‐derived mesenchymal stromal cells (BM‐MSCs) in patients with chronic low back pain from moderate‐to‐advanced multilevel disc degeneration.
Gianluca Vadalà, Fabrizio Russo, Cristiana Lavazza, Giorgia Petrucci, Luca Ambrosio, Silvia Budelli, Elisa Montelatici, Giuseppina Di Giacomo, Claudia Cicione, Veronica Tilotta, Giuseppe Francesco Papalia, Matteo Pileri, Amalia Bruno, Salvatore La Rosa, Emilio Carrino, Eliodoro Faiella, Massimiliano Carassiti, Lorenza Lazzari, Rocco Papalia, Vincenzo Denaro   +19 more
wiley   +1 more source

Resveratrol: Molecular Mechanisms, Health Benefits, and Potential Adverse Effects

MedComm, Volume 6, Issue 6, June 2025.
As a polyphenol substance with important potential, resveratrol has important potential in degenerative diseases, cardiovascular diseases, cancer, neurological diseases, etc. However, it is still necessary to pay attention to its bioavailability and potential adverse effects.
Zhuo‐qun Ren, Sheng‐yuan Zheng, Zhengcheng Sun, Yan Luo, Yu‐tong Wang, Ping Yi, Yu‐sheng Li, Cheng Huang, Wen‐feng Xiao   +8 more
wiley   +1 more source

Finite element models of intervertebral disc: recent advances and prospects. [PDF]

Ann Med
Sun T, Wang J, Liu X, Huang H, Wang J, Suo M, Zhang J, Li Z.   +7 more
europepmc   +1 more source

Associations Between Type‐Specific Sedentary Behaviour and Low Back Pain: Evidence From a Large‐Scale Cohort Study

Musculoskeletal Care, Volume 23, Issue 2, June 2025.
ABSTRACT Objective This study aimed to investigate the association between different types of sedentary behaviour and the risk of low back pain (LBP) and LBP intensity. Methods Data were obtained from a large‐scale cohort survey of Koreans comprising 2742 participants.
On Lee, DooYong Park
wiley   +1 more source

Multiscale mechanical-adapted hydrogels for the repair of intervertebral disc degeneration. [PDF]

Bioact Mater
Cai W, Yang F, Yang C, Liu Y, Xu H, Zhang W, Li B, Han F, Luo Z, Liang T.   +9 more
europepmc   +1 more source

Challenges and Innovative Strategies in 3D Printing of Natural Biomolecular Hydrogels

Nano Select, Volume 6, Issue 6, June 2025.
ABSTRACT Natural biomolecules with excellent biocompatibility, degradability, and the ability to guide effective tissue regeneration are considered ideal materials for constructing tissue engineering hydrogel scaffolds. The employing of 3D printing technology facilitates the preparation of natural biomolecular‐based scaffold for specific morphological
Jiaqi Qiu, Shuo Ma, Xue Qu
wiley   +1 more source

Stem cell therapy for intervertebral disc degeneration: Clinical progress with exosomes and gene vectors. [PDF]

World J Stem Cells
Li ZP, Li H, Ruan YH, Wang P, Zhu MT, Fu WP, Wang RB, Tang XD, Zhang Q, Li SL, Yin H, Li CJ, Tian YG, Han RN, Wang YB, Zhang CJ.   +15 more
europepmc   +1 more source