Results 101 to 110 of about 84,616 (318)

Genetic factors in intervertebral disc degeneration

Genes & Diseases, 2016
Low back pain (LBP) is a major cause of disability and imposes huge economic burdens on human society worldwide. Among many factors responsible for LBP, intervertebral disc degeneration (IDD) is the most common disorder and is a target for intervention. The etiology of IDD is complex and its mechanism is still not completely understood.
Feng, Yi, Egan, Brian, Wang, Jinxi
openaire   +2 more sources

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration [PDF]

Arthritis Research & Therapy, 2007
AbstractCurrent evidence implicates intervertebral disc degeneration as a major cause of low back pain, although its pathogenesis is poorly understood. Numerous characteristic features of disc degeneration mimic those seen during ageing but appear to occur at an accelerated rate.
Le Maitre, Christine Lyn, Freemont, Anthony John, Hoyland, Judith Alison   +2 more
openaire   +4 more sources

The causality between smoking and intervertebral disc degeneration mediated by IL-1β secreted by macrophage: A Mendelian randomization study

Heliyon
There is still a lack of high-level evidence regarding the causal relationship between smoking and intervertebral disc degenerative diseases. This study utilized data from genome wide analysis studies and conducted two-sample Mendelian randomization ...
Zhaopu Han, Yicheng Chen, Xiaojian Ye
doaj   +1 more source

STUDIES OF MOLECULAR CHANGES IN INTERVERTEBRAL DISC DEGENERATION IN ANIMAL MODEL [PDF]

Acta Ortopédica Brasileira, 2016
Objective: To evaluate the structural and molecular changes in the extracellular matrix (ECM) during the process of intervertebral disc degeneration, using animal model.
Marcelo Ferraz de Campos, Cintia Pereira de Oliveira, Charles Benjamin Neff, Olga Maria de Toledo Correa, Maria Aparecida Silva Pinhal, Luciano Miller Reis Rodrigues   +5 more
doaj   +2 more sources

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. [PDF]

, 2016
The main pathogenesis of intervertebral disc (IVD) herniation involves disruption of the annulus fibrosus (AF) caused by ageing or excessive mechanical stress and the resulting prolapse of the nucleus pulposus.
Asahara, Hiroshi, Ichinose, Shizuko, Inagawa, Masayo, Inui, Masafumi, Ito, Yoshiaki, Kataoka, Kensuke, Kayama, Tomohiro, Lotz, Martin K, Masuda, Koichi, Mori, Masaki, Nakamichi, Ryo, Onizuka, Naoko, Ozaki, Toshifumi, Sakai, Daisuke, Suzuki, Hidetsugu   +14 more
core   +1 more source

Exosome‐Based Cartilage‐Targeted Delivery System: Strategies and Applications

Small Science, EarlyView.
Construction strategies and applications of cartilage‐targeting exosomes. With the ageing of the global population, cartilage‐related diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD), have increasingly become significant social problems threatening human health. Therefore, targeted therapy for cartilage is becoming more
Yao Wang, Bo Chen, Haodong Zhu, Zhenyu Sun   +3 more
wiley   +1 more source

Cervical intervertebral disc degeneration and dizziness

World Journal of Clinical Cases, 2021
Clinical studies have found that patients withcervical degenerative disease are usually accompanied by dizziness. Anterior cervical surgery can eliminate not only chronic neck pain, cervical radiculopathy or myelopathy, but also dizziness. Immunohistochemical studies show that a large number of mechanoreceptors, especially Ruffini corpuscles, are ...
Liu, Tang-Hua, Liu, Yan-Qing, Peng, Bao-Gan   +2 more
openaire   +2 more sources

Finite Element Analysis of Stress Distribution and Range of Motion in Discogenic Back Pain [PDF]

Neurospine
Objective Precise knowledge regarding the mechanical stress applied to the intervertebral disc following each individual spine motion enables physicians and patients to understand how people with discogenic back pain should be guided in their exercises ...
Pyung-Goo Cho, Seon-Jin Yoon, Dong Ah Shin, Min Cheol Chang   +3 more
doaj   +1 more source

Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling

Frontiers in Immunology, 2023
BackgroundIntervertebral disc degeneration (IVDD) is a leading cause of low back pain (LBP). The pathological process of IVDD is associated with inflammatory reactions and extracellular matrix (ECM) disorders.
Qunbo Meng, Qunbo Meng, Kaiwen Liu, Kaiwen Liu, Zhenchuan Liu, Zhenchuan Liu, Jinbo Liu, Jinbo Liu, Ziyu Tian, Ziyu Tian, Shanshan Qin, Jianlu Wei, Jianlu Wei, Lei Cheng, Lei Cheng   +14 more
doaj   +1 more source

Co-culture of Adult Mesenchymal Stem Cells and Nucleus Pulposus Cells in Bilaminar Pellets for Intervertebral Disc Regeneration [PDF]

, 2009
Background: Our goal is to optimize stem cell-based tissue engineering strategies in the context of the intervertebral disc environment. We explored the benefits of co-culturing nucleus pulposus cells (NPC) and adult mesenchymal stem cells (MSC) using a ...
Allon, AA, Lotz, JC, Schneider, RA
core   +2 more sources