Results 101 to 110 of about 38,647 (321)

Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges

Advanced NanoBiomed Research, EarlyView.
Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong   +7 more
wiley   +1 more source

MiR-532 downregulation of the Wnt/β-catenin signaling via targeting Bcl-9 and induced human intervertebral disc nucleus pulposus cells apoptosis

Journal of Pharmacological Sciences, 2018
Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration.
Zeyu Sun, Yuekui Jian, Hongying Fu, Bo Li   +3 more
doaj  

Advances in Comparative Medical Research on Anatomy and Histological Structure of Intervertebral Discs in Humans and Other Animals

Shiyan dongwu yu bijiao yixue
The 2023 China Health Report on Spine Degeneration noted a significant increase in lumbar surgery among patients under 35 years old in recent years, indicating a trend towards younger onset of cervical and lumbar diseases.
ZHANG Li, HAN Lingxia, KUANG Yu
doaj   +1 more source

Early changes in the extracellular matrix of the degenerating intervertebral disc, assessed by Fourier transform infrared imaging. [PDF]

, 2018
Mechanical overloading induces a degenerative cell response in the intervertebral disc. However, early changes in the extracellular matrix (ECM) are challenging to assess with conventional techniques.
Emanuel, Kaj S, Kingma, Idsart, Mader, Kerstin T, Peeters, Mirte, Rustenburg, Christine M E, Sammon, Christopher, Smit, Theodoor H, Vergroesen, Pieter-Paul A   +7 more
core   +3 more sources

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Engineering Efferocytosis for Bone Regeneration

Macromolecular Bioscience, EarlyView.
The repair of bone tissue in acute and chronic injuries is a significant long‐standing clinical challenge. Biomaterials‐based interventions are well‐positioned to interrogate mechanisms of efferocytosis due to their ability to provide support and guide cellular activity.
Jacob Miszuk, Linna Zhong, Hongli Sun
wiley   +1 more source

Sauteur d'Alfort rabbit‐like locomotory disturbances and eye disorders in two pet rabbits—‘handstand rabbits’

Veterinary Record Case Reports, EarlyView.
Abstract Homozygous sauteur d'Alfort rabbits have a splicing‐site mutation in the RAR‐related orphan receptor B (RORB) gene that causes changes in their locomotion. These rabbits sometimes walk on their thoracic limbs, especially at higher speeds. They also experience additional abnormalities, including eye alterations such as blindness due to retinal ...
Kerstin Müller, Sabine Schulze, Katharina Thieme, Robert Klopfleisch, Miguel Carneiro   +4 more
wiley   +1 more source

Degeneration and regeneration of the intervertebral disc: lessons from development

Disease Models & Mechanisms, 2011
Degeneration of the intervertebral discs, a process characterized by a cascade of cellular, biochemical, structural and functional changes, is strongly implicated as a cause of low back pain.
Lachlan J. Smith, Nandan L. Nerurkar, Kyung-Suk Choi, Brian D. Harfe, Dawn M. Elliott   +4 more
doaj   +1 more source

A Case of Degeneration of the Intervertebral Disc following Lumbar Puncture [PDF]

, 1942
P. G. Epps
openalex   +1 more source