Results 101 to 110 of about 81,428 (351)

Degeneration of the intervertebral disc with new approaches for treating low back pain. [PDF]

, 2015
This review paper discusses the process of disc degeneration and the current understanding of cellular degradation in patients who present with low back pain.
Binch, AL, Hughes, SP, Le Maitre, CL, Thorpe, AA   +3 more
core  

Biomechanical study of intervertebral disc degeneration

, 2023
Degeneration and age affect the biomechanics of the intervertebral disc, by reducing its stiffness, flexibility and shock absorption capacities against daily movement and spinal load. The biomechanical characterization of intervertebral discs is achieved by conducting mechanical testing to vertebra-disc-vertebra segments and applying axial, shear, bend
openaire   +4 more sources

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen   +11 more
wiley   +1 more source

Comparison of Posterior Pedicle Screw Fixation and Lateral Fixation in the Extreme Lateral Interbody Fusion in Lumbar Degenerative Disease Patients with Osteopenia or Osteoporosis

Orthopaedic Surgery, Volume 14, Issue 12, Page 3283-3292, December 2022., 2022
The purpose of this study was to assess and compare the therapeutic effects of posterior bilateral pedicle screw fixation and lateral fixation in the extreme lateral interbody fusion (XLIF) in patients with osteopenia or osteoporosis. The bilateral pedicle screw fixation had more advantages in long term stable fixation and was more suitable for the ...
Xianzheng Wang, Huanan Liu, Weijian Wang, Yapeng Sun, Fei Zhang, Lei Guo, Jiaqi Li, Wei Zhang   +7 more
wiley   +1 more source

SpineNetV2: Automated Detection, Labelling and Radiological Grading Of Clinical MR Scans [PDF]

arXiv, 2022
This technical report presents SpineNetV2, an automated tool which: (i) detects and labels vertebral bodies in clinical spinal magnetic resonance (MR) scans across a range of commonly used sequences; and (ii) performs radiological grading of lumbar intervertebral discs in T2-weighted scans for a range of common degenerative changes. SpineNetV2 improves
arxiv  

STUDIES OF MOLECULAR CHANGES IN INTERVERTEBRAL DISC DEGENERATION IN ANIMAL MODEL [PDF]

Acta Ortopédica Brasileira, 2016
Objective: To evaluate the structural and molecular changes in the extracellular matrix (ECM) during the process of intervertebral disc degeneration, using animal model.
Marcelo Ferraz de Campos, Cintia Pereira de Oliveira, Charles Benjamin Neff, Olga Maria de Toledo Correa, Maria Aparecida Silva Pinhal, Luciano Miller Reis Rodrigues   +5 more
doaj   +2 more sources

Biochemical Factors of Intervertebral Disc Degeneration: Implications for Disc Regeneration [PDF]

, 2007
Intervertebral disc degeneration is main cause of various spinal degenerative conditions, and results in a significant socio-economic burden and morbidity to those affected.
문성환
core   +1 more source

A mouse coccygeal intervertebral disc degeneration model with tail‐looping constructed using a suturing method

Animal Models and Experimental Medicine, EarlyView.
A novel, simple coccygeal intervertebral disc degeneration model, using a suturing method for tail‐looping, without the need for external fixation and complex surgery. The model has high reproducibility and stability and overcomes the disadvantages of the existing animal models of disc degeneration.
Wei Xie, Zemao Huang, Ziyang Huang, Deqing Luo, Zhangxin Chen, Li Xie, Lingqi Zhu, Hui Liu, Kejian Lian, Paolo Alberton, Denitsa Docheva, Dasheng Lin   +11 more
wiley   +1 more source

Three‐dimensional High‐definition Exoscope in Minimally Invasive Transforaminal Lumbar Interbody Fusion: A Retrospective Cohort Study

Orthopaedic Surgery, Volume 15, Issue 1, Page 187-196, January 2023., 2023
The operative microscope (OM) has revolutionized the field of modern spine surgery; however, it remains limited by several drawbacks. Recently, the exoscope (EX) system, has been designed to assistant spine surgery. It provides a three‐dimensional high‐definition operative experience and becomes an alternative tool to the OM.
Ya‐Wei Yao, Zhi‐Peng Yao, Ming Jiang, Wen‐Xiong Zhu, Fang‐qiang Zhu, Cheng‐Jie Xiong, Feng Xu   +6 more
wiley   +1 more source

Structure-function relationships at the human spinal disc-vertebra interface. [PDF]

, 2018
Damage at the intervertebral disc-vertebra interface associates with back pain and disc herniation. However, the structural and biomechanical properties of the disc-vertebra interface remain underexplored.
Adams, Adams, Adams, Adams, Arce, Ayache, Bae, Balkovec, Benjamin, Brown, DeLucca, DeLucca, Fields, Fields, Genin, Green, Guerin, Ho, Hulme, Inoue, Jazrawi, Lama, Law, Lecompte, Liu, Nosikova, Paietta, Raghupathy, Rajasekaran, Roberts, Roberts, Rodrigues, Silva, Tanaka, Thomopoulos, Thomopoulos, Thompson, Thompson, Wade, Wagermaier, Wang, Wang, Willburger, Yoshiaki   +43 more
core   +1 more source