Results 111 to 120 of about 84,616 (318)

Hydrogel Microspheres for Biomedical Applications

Small Science, EarlyView.
Hydrogel microspheres (HMs) play pivotal roles in biomedical applications, such as drug delivery, cell culture, regenerative medicine, wound healing, and tumor immunity. This review focuses on the latest findings to provide a more comprehensive understanding of HMs for biomedical applications.
Yingkang Huang, Xi Zhu, Jinhong Zhou, Henan Li, Wei Zhang, Danyang Shen, Ziyan Huang, Tianbo Zhang, Lin Zhuang, Lei Qin, Xiaofeng Xue, Yunjie Lu   +11 more
wiley   +1 more source

Cell therapy for the degenerating intervertebral disc [PDF]

Translational Research, 2017
Spinal conditions related to intervertebral disc (IVD) degeneration cost billions of dollars in the US annually. Despite the prevalence and soaring cost, there is no specific treatment that restores the physiological function of the diseased IVD. Thus, it is vital to develop new treatment strategies to repair the degenerating IVD.
Wei Tong, Zhouyu Lu, Ling Qin, Robert L. Mauck, Harvey E. Smith, Lachlan J. Smith, Neil R. Malhotra, Martin F. Heyworth, Franklin Caldera, Motomi Enomoto-Iwamoto, Yejia Zhang   +10 more
openaire   +2 more sources

Intervertebral Disc Degeneration

, 2017
The human spine consists of 23 intervertebral discs adjoining the vertebral bodies. These discs provide mechanical support and spinal motion and function to distribute loads from daily activities. Tissues of intervertebral discs share similarities to those of diarthrodial joints, such as a thin layer of cartilage that lines the interface between the ...
Akansha M. Shah, Sarah Yoon Ji Kwon, Wilson C. W. Chan, Danny Chan   +3 more
openaire   +6 more sources

Evaluation of magnetic resonance imaging guidelines for differentiation between thoracolumbar intervertebral disk extrusions and intervertebral disk protrusions in dogs [PDF]

, 2016
Four MRI variables have recently been suggested to be independently associated with a diagnosis of thoracolumbar intervertebral disk extrusion or protrusion.
Aikawa, Aikawa, Altman, Baltzer, Bergknut, Bergknut, Berknut, Besalti, Bos, Bray, Brisson, Brisson, Cihangiroglu, Cudia, da Costa, Decker, Decker, Decker, Downes, Fenn, Fisher, Flegel, Fleis, Gomes, Griffiths, Hansen, Knight, Landis, Lee, Macias, McKee, Modic, Moissonnier, Olby, Olby, Petersen, Rehman, Rihn, Robertson, Ruddle, Salger, Sander, Seiler, Sim, Smolders, Solgaard Sorensen, Song, Truszczyńska, Wie   +48 more
core   +1 more source

Nanozyme‐Integrated 3D‐Printed Gradient Scaffold Rescues Redox Homeostasis for Enhanced Osteochondral Repair

Small Structures, EarlyView.
This work presents a novel 3D‐printed gradient scaffold for osteochondral repair. The implant features distinct layers, each designed for a specific therapeutic role: a cartilage layer protects tissue and a bone layer promotes regeneration. In vivo experiments confirm the scaffold's effectiveness, demonstrating its dual ability to maintain chondrocyte ...
Chuan Hu, Dingqi Xie, Jianyi Li, Yang Jin, Jiechao Xia, Gu Jin, Lin Ye, Zhijun Hu   +7 more
wiley   +1 more source

Integrated transcriptome and proteome analyses identify novel regulatory network of nucleus pulposus cells in intervertebral disc degeneration

BMC Medical Genomics, 2021
Background Degeneration of intervertebral disc is a major cause of lower back pain and neck pain. Studies have tried to unveil the regulatory network using either transcriptomic or proteomic analysis.
Chen Xu, Shengchang Luo, Leixin Wei, Huiqiao Wu, Wei Gu, Wenchao Zhou, Baifeng Sun, Bo Hu, Hongyu Zhou, Yang Liu, Huajiang Chen, Xiaojian Ye, Wen Yuan   +12 more
doaj   +1 more source

Content Analysis of General Practitioner Requested Lumbar Spine X-ray Reports [PDF]

, 2007
Aims and Background X-rays of patients with low back pain rarely show serious pathology but frequently reveal incidental age-related changes and always expose people to radiation.
Carr, Eloise C.J., Thompson, Paul W.
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Inflammation in intervertebral disc degeneration and regeneration [PDF]

Journal of The Royal Society Interface, 2015
Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a problem with a heavy economic burden, which has been increasing in prevalence as populations age. Deeper knowledge of the complex spatial and temporal orchestration of cellular interactions and extracellular matrix remodelling is critical to improve current IVD ...
Maria, Molinos, Catarina R, Almeida, Joana, Caldeira, Carla, Cunha, Raquel M, Gonçalves, Mário A, Barbosa   +5 more
openaire   +3 more sources

Structure-function relationships at the human spinal disc-vertebra interface. [PDF]

, 2018
Damage at the intervertebral disc-vertebra interface associates with back pain and disc herniation. However, the structural and biomechanical properties of the disc-vertebra interface remain underexplored.
Adams, Adams, Adams, Adams, Arce, Ayache, Bae, Balkovec, Benjamin, Brown, DeLucca, DeLucca, Fields, Fields, Genin, Green, Guerin, Ho, Hulme, Inoue, Jazrawi, Lama, Law, Lecompte, Liu, Nosikova, Paietta, Raghupathy, Rajasekaran, Roberts, Roberts, Rodrigues, Silva, Tanaka, Thomopoulos, Thomopoulos, Thompson, Thompson, Wade, Wagermaier, Wang, Wang, Willburger, Yoshiaki   +43 more
core   +1 more source