Results 111 to 120 of about 25,892 (278)
Aging Cell, Volume 25, Issue 2, February 2026.Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang +11 more
wiley +1 more source
Herbal Formula Modified Bu-Shen-Huo-Xue Decoction Attenuates Intervertebral Disc Degeneration via Regulating Inflammation and Oxidative Stress [PDF]
, 2022 Jialiang Lin +3 more
openalex +1 more source
Biological Reviews, Volume 101, Issue 1, Page 268-278, February 2026.ABSTRACT Intervertebral disc degeneration (IDD) can contribute to lower back and neck pain. In IDD, the most affected component of the intervertebral disc is the nucleus pulposus (NP). Derived from the notochord, where cells are organized into a tandem configuration, young NP cells cluster in three‐dimensional (3D) networks embedded in a gelatinous ...
Xiangyun Wei, Nam Vo, Gwendolyn A. Sowa
wiley +1 more source
Structural Interface Engineering Unlocks Native‐Like Mechanics in Biomimetic Intervertebral Discs
Advanced Materials Interfaces, Volume 13, Issue 1, 7 January 2026.Engineered interlamellar and radial fibrous interfaces enable biomimetic intervertebral disc constructs to replicate native mechanical behavior. Suture‐reinforced laminates enhance cohesion and shear strength, while radial fibers improve compressive resilience and stress redistribution.
Haim S. Mordechai +3 more
wiley +1 more source
Genetic Predictors of Early-Onset Spinal Intervertebral Disc Degeneration: Part One of Two [PDF]
, 2021 Brian Fiani +2 more
openalex +1 more source
Advanced Science, Volume 13, Issue 3, 14 January 2026.CircPROSC promotes craniosynostosis by sponging miR‐6815‐5p, thereby activating WNT3A/β‐catenin signaling and enhancing RUNX2‐mediated osteogenesis. Targeted silencing of circPROSC with MSC membrane–coated siRNA nanoparticles (MM@Lipo/si‐circPROSC) delivered postnatally into cranial sutures attenuates premature suture closure in Twist1+/– mice ...
Zhenkun Weng +6 more
wiley +1 more source
MicroRNA-338-3p as a novel therapeutic target for intervertebral disc degeneration [PDF]
, 2021 Hua Jiang +5 more
openalex +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study investigates the role of PACS‐2 in IDD, demonstrating that it suppresses the nuclear translocation of SP1, thereby downregulating its downstream target LRRK2. This reduces LRRK2‐mediated ubiquitination and degradation of Mfn2 through the JNK pathway, preserving MAM integrity and promoting NPSC survival.
Liang Kang +19 more
wiley +1 more source
A novel multi-omics approach for identifying key genes in intervertebral disc degeneration [PDF]
Xuan Zhao +5 more
openalex +1 more source
miR‐328‐5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2 [PDF]
, 2022 Jing Yan +6 more
openalex +1 more source