Results 111 to 120 of about 38,647 (321)

Vertebral canine myxosarcoma with neurological signs treated by vertebroplasty and radiotherapy (in a dog)

Veterinary Record Case Reports, EarlyView.
Abstract Canine myxosarcomas are an uncommon group of tumours, with therapeutic modalities still under research. This case report describes a vertebral myxosarcoma in a 5‐year‐old, mixed‐breed dog causing pelvic limb ataxia. Diagnostic modalities included computed tomography and histopathology.
Flavie Deschildre, Charles Porsmoguer, Nicolas Diop, Noah Lauwereys, Margaux Blondel   +4 more
wiley   +1 more source

Deep Learning Approach for Automated Estimation of 3D Vertebral Orientation of the Lumbar Spine

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Lumbar degenerative disc diseases constitute a major contributor to lower back pain. In pursuit of an enhanced understanding of lumbar degenerative pathology and the development of more effective treatment modalities, the application of precise measurement techniques for lumbar segment kinematics is imperative.
Nanfang Xu, Shanshan Liu, Yuepeng Chen, Kailai Zhang, Chenyi Guo, Cheng Zhang, Fei Xu, Qifeng Lan, Wanyi Fu, Xingyu Zhou, Bo Zhao, Aodong He, Xiangling Fu, Ji Wu, Weishi Li   +14 more
wiley   +1 more source

Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro‐Inflammatory Phenotype of Senescent Cells

Aging Cell, EarlyView.
As a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Birong Jiang, Hongwei Zhang, Qixia Xu, Zhirui Jiang, Ruikun He, Qiang Fu, Yu Sun   +6 more
wiley   +1 more source

Degenerative relationships in lumbar intervertebral discs and facet joints: an MRI-based comparative study of asymptomatic individuals and patients with chronic and intermittent low back pain

Frontiers in Bioengineering and Biotechnology
Degeneration of intervertebral discs and facet joints are common conditions that are thought to be interrelated. This study aimed to investigate the morphological interplay between disc and facet degeneration, as well as relationships between adjacent ...
Hendrik Schmidt, Sandra Reitmaier, Daishui Yang, Georg Duda, Matthias Pumberger   +4 more
doaj   +1 more source

Degeneration of the intervertebral disc with new approaches for treating low back pain. [PDF]

, 2015
This review paper discusses the process of disc degeneration and the current understanding of cellular degradation in patients who present with low back pain.
Binch, AL, Hughes, SP, Le Maitre, CL, Thorpe, AA   +3 more
core  

Targeting FABP4 to Inhibit AGEs‐RAGE/NF‐κB Signalling Effectively Ameliorates Nucleus Pulposus Dysfunction and Angiogenesis in Obesity‐Related Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Obesity promotes the progression of intervertebral disc degeneration (IVDD) through the mTORC1/FABP4 axis. Targeting FABP4 effectively ameliorates nucleus pulposus dysfunction and angiogenesis in obesity‐related IVDD. ABSTRACT Intervertebral disc degeneration (IVDD) is a primary contributor to low back pain, posing significant social and economic ...
Lin Han, Fudong Li, Huiqiao Wu, Weiheng Wang, Peiwen Chen, Weicheng Xia, Yang Liu, Kaiqiang Sun, Wenbo Lin   +8 more
wiley   +1 more source

Intervertebral disc degeneration, inflammation, and bioactive lipids

Recent Trends in Pharmacology
Intervertebral disc degeneration, inflammation, and bioactive lipidsIntervertebral disc degenerationIntervertebral disc (IVD) degeneration is a common condition that is associated with significant morbidity.
Undurti Das, Ahmet Hacımüftüoğlu
doaj   +1 more source

Mechanical Conditions That Accelerate Intervertebral Disc Degeneration: Overload Versus Immobilization [PDF]

, 2004
Ian A. F. Stokes, James C. Iatridis
openalex   +1 more source

Engineering Intervertebral Disc Regeneration: Biomaterials, Cell Sources and Animal Models

Cell Proliferation, EarlyView.
This review highlights the current tissue engineering approaches utilising biomaterials, animal models and cell sources for intervertebral disc regeneration and discusses future opportunities. ABSTRACT Intervertebral disc (IVD) degeneration is an age‐related problem triggering chronic spinal issues, such as low back pain and IVD herniation.
Sidong Yang, Farhad Soheilmoghaddam, Peter Pivonka, Joan Li, Samuel Rudd, Trifanny Yeo, Ji Tu, Yibo Zhu, Justin J. Cooper‐White   +8 more
wiley   +1 more source

Machine learning and single-cell analysis identify the mitophagy-associated gene TOMM22 as a potential diagnostic biomarker for intervertebral disc degeneration

Heliyon
Background: Mitophagy selectively eliminates potentially cytotoxic and damaged mitochondria and effectively prevents excessive cytotoxicity from damaged mitochondria, thereby attenuating inflammatory and oxidative responses.
Yinghao Wu, Shengting Wu, Zhiheng Chen, Erzhu Yang, Haiyue Yu, Guowang Zhang, XiaoFeng Lian, JianGuang Xu   +7 more
doaj