Results 151 to 160 of about 38,647 (321)

Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits [PDF]

, 2010
Takashi Miyamoto, Takeshi Muneta, Takashi Tabuchi, Kenji Matsumoto, Hirohisa Saito, Kunikazu Tsuji, Ichiro Sekiya   +6 more
openalex   +1 more source

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This study aims to validate an underutilized canine preclinical model of discogenic back pain model by deep phenotyping several structural and pain associated outcomes with novel findings in the areas of RNA sequencing and whole patch clamp of canine dorsal root ganglion neurons.
Mary K. Heimann, Shirley N. Tang, Gilian Gunsch, Kyle Kuchynsky, Brett Klamer, Fangli Zhao, Megan Co, Maciej Pietrzak, Justin Richards, Jake Klausner, Adam Smith, Kaitlyn Cimney, Sara McBride‐Gagyi, Brad Youngblood, Kara Corps, Candice Askwith, Benjamin A. Walter, Sarah A. Moore, Devina Purmessur   +18 more
wiley   +1 more source

Degenerative Disc Disease: A Review of Cell Technologies and Stem Cell Therapy

Iranian Journal of Neurosurgery, 2016
Background & Aim: Low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration.
Kaveh Haddadi
doaj  

Micro-CT quantification of subchondral endplate changes in intervertebral disc degeneration [PDF]

, 2010
Joost Rutges, O.P. Jagt van der, F. Cumhur Öner, A.J. Verbout, Rene Castelein, J. Alain Kummer, Harrie Weinans, Laura B. Creemers, Wouter J.A. Dhert   +8 more
openalex   +1 more source

Mechanistic Interactions Driving Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration: A Multi‐Axial Perspective of Mechanical, Immune, and Metabolic Pathways

JOR SPINE, Volume 8, Issue 3, September 2025.
The senescence of NPCs is at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back discomfort. ABSTRACT Background The senescence of nucleus pulposus cells (NPCs) at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back pain.
Yunbo Yang, Haoming Li, Junhui Zuo, Fei Lei   +3 more
wiley   +1 more source

Biomechanical analysis of bone mesoscopic structure and mechanical properties of vertebral endplates of degenerated intervertebral discs in rabbits

Medicine in Novel Technology and Devices
In previous studies of disc degeneration, the structural and mechanical properties of the endplate were often neglected. In this paper, the station legislation was used to construct an animal model of minor trauma disc degeneration, and the mechanism of ...
Bingying Zhao, Yuan Guo, Xushu Zhang, Yibo Zhao, Bin Zhao, Ming Zhang   +5 more
doaj  

Interleukin 1 Polymorphisms and Intervertebral Disc Degeneration

, 2004
Svetlana Solovieva, Sanna Kouhia, Päivi Leino‐Arjas, Leena Ala‐Kokko, Katariina Luoma, Raili Raininko, Janna Saarela, Hilkka Riihimäki   +7 more
openalex   +1 more source

Intervertebral disc degeneration in dogs

, 2010
Back pain is common in both dogs and humans, and is often associated with intervertebral disc (IVD) degeneration. The IVDs are essential structures of the spine and degeneration can ultimately result in diseases such as IVD herniation or spinal instability.
openaire   +3 more sources

Development and Validation of a Machine Learning‐Based Online Prognostic Model for Cervical Spondylosis Patients After Anterior Cervical Discectomy and Fusion: A Multicenter Study

JOR SPINE, Volume 8, Issue 3, September 2025.
This was a multi‐center, retrospective, and prospective study based on multiple machine learning algorithms. This online predictive tool offers a robust framework for personalized postoperative management in CS patients, potentially improving clinical outcomes.
Sitan Feng, Shengsheng Huang, Zhongxian Zhou, Bin Zhang, Chengqian Huang, Tianyou Chen, Chenxing Zhou, Shaofeng Wu, Jichong Zhu, Jiarui Chen, Jiang Xue, Xinli Zhan, Chong Liu   +12 more
wiley   +1 more source

Short‐Term Dynamic Unloading of Bovine Tail Discs in Culture Partially Mitigates Induced Degeneration After One‐Strike Trigger

JOR SPINE, Volume 8, Issue 3, September 2025.
In a bovine intervertebral disc organ culture study including biological and mechanical evaluation parameters, unloading ‐compared to loading‐ partially mitigated the degenerative cascade (Timepoint 2) previously induced with a one‐strike trigger (Timepoint 1).
Astrid Soubrier, Hermann Kasper, Nadja Vonlanthen, Ilse Jonkers, Sibylle Grad   +4 more
wiley   +1 more source