Results 71 to 80 of about 40,704 (209)

RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE? [PDF]

, 2016
Transcription factor tonicity-responsive enhancer-binding protein (TonEBP/NFAT5) is critical for osmo-adaptation and extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue niche.
Johnson, Zariel I., Risbud, Makarand V., Shapiro, Irving M.   +2 more
core   +2 more sources

Biomechanical analysis of bone mesoscopic structure and mechanical properties of vertebral endplates of degenerated intervertebral discs in rabbits

Medicine in Novel Technology and Devices
In previous studies of disc degeneration, the structural and mechanical properties of the endplate were often neglected. In this paper, the station legislation was used to construct an animal model of minor trauma disc degeneration, and the mechanism of ...
Bingying Zhao, Yuan Guo, Xushu Zhang, Yibo Zhao, Bin Zhao, Ming Zhang   +5 more
doaj   +1 more source

Polyethylene microplastics promote nucleus pulposus cell senescence by inducing oxidative stress via TLR4/NOX2 axis

Ecotoxicology and Environmental Safety
This study aimed to detect and characterize microplastics in intervertebral disc and investigate their effects and molecular mechanism on intervertebral disc degeneration.
Weilin Zhang, Zhencong Li, Zhongwei Wang, Kuize Liu, Shengbang Huang, Jinguo Liang, Zhiwen Dai, Weixiong Guo, Chao Mao, Siyuan Chen, Jinsong Wei   +10 more
doaj   +1 more source

Molecular Mechanisms of Intervertebral Disc Degeneration

Spine Surgery and Related Research, 2019
Intervertebral disc degeneration is a well-known cause of disability, the result of which includes neck and back pain with associated mobility limitations.
Sean Rider, Shuichi Mizuno, James Kang
doaj   +1 more source

A Case of Degeneration of the Intervertebral Disc following Lumbar Puncture [PDF]

, 1942
P. G. Epps
openalex   +1 more source

Degenerative relationships in lumbar intervertebral discs and facet joints: an MRI-based comparative study of asymptomatic individuals and patients with chronic and intermittent low back pain

Frontiers in Bioengineering and Biotechnology
Degeneration of intervertebral discs and facet joints are common conditions that are thought to be interrelated. This study aimed to investigate the morphological interplay between disc and facet degeneration, as well as relationships between adjacent ...
Hendrik Schmidt, Sandra Reitmaier, Daishui Yang, Georg Duda, Matthias Pumberger   +4 more
doaj   +1 more source

Correlation of Early Outcomes and Intradiscal Interleukin-6 Expression in Lumbar Fusion Patients. [PDF]

, 2020
OBJECTIVE: To determine if there is correlation between intradiscal levels of interleukin-6 (IL-6) and early outcome measures in patients undergoing lumbar fusion for painful disc degeneration.
Anderson, D Greg, Antonacci, Christopher L, Kepler, Chris K, Koerner, John D, Markova, Dessislava Z, Mendelis, Joseph, Schroeder, Greg D, Vaccaro, Alexander R   +7 more
core   +1 more source

Zhiqiao Gancao decoction regulated JAK2/STAT3/ macrophage M1 polarization to ameliorate intervertebral disc degeneration

Heliyon
Background: Zhiqiao Gancao decoction (ZQGCD) was created by Professor Gong Zhengfeng, a renowned Chinese medicine expert. Clinical studies have shown its efficacy in alleviating pain and enhancing lumbar function in intervertebral disc degeneration (IDD)
Zeling Huang, Xiaofeng Shen, Hua Chen, Zaishi Zhu, Binjie Lu, Long Zhang, Yujiang Liu, Yuwei Li, Bo Xu   +8 more
doaj   +1 more source

Degeneration and regeneration of the intervertebral disc: lessons from development

Disease Models & Mechanisms, 2011
Degeneration of the intervertebral discs, a process characterized by a cascade of cellular, biochemical, structural and functional changes, is strongly implicated as a cause of low back pain.
Lachlan J. Smith, Nandan L. Nerurkar, Kyung-Suk Choi, Brian D. Harfe, Dawn M. Elliott   +4 more
doaj   +1 more source

Degeneration of the intervertebral disc. [PDF]

, 2003
Jill Urban, Sally Roberts
openalex   +1 more source