Results 21 to 30 of about 539,014 (352)

Human organoids are superior to cell culture models for intestinal barrier research

Frontiers in Cell and Developmental Biology, 2023
Loss of intestinal epithelial barrier function is a hallmark in digestive tract inflammation. The detailed mechanisms remain unclear due to the lack of suitable cell-based models in barrier research.
Catherine Kollmann, Hannah Buerkert, Michael Meir, Konstantin Richter, Kai Kretzschmar, Sven Flemming, Matthias Kelm, Christoph-Thomas Germer, Christoph Otto, Natalie Burkard, Nicolas Schlegel   +10 more
doaj   +1 more source

Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function

International Journal of Molecular Sciences, 2021
Disruptions in the intestinal epithelial barrier can result in devastating consequences and a multitude of disease syndromes, particularly among preterm neonates.
Elizabeth C Rose, J. Odle, A. Blikslager, A. Ziegler   +3 more
semanticscholar   +1 more source

Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling

Microbiome, 2023
Background The intestinal epithelial barrier confers protection against the intestinal invasion by pathogens and exposure to food antigens and toxins. Growing studies have linked the gut microbiota to the intestinal epithelial barrier function.
Jun Hu, Jianwei Chen, Xiaojian Xu, Qiliang Hou, Jing Ren, Xianghua Yan   +5 more
doaj   +1 more source

A Multi-Strain Probiotic Formulation Improves Intestinal Barrier Function by the Modulation of Tight and Adherent Junction Proteins

Cells, 2022
In healthy individuals, tight junction proteins (TJPs) maintain the integrity of the intestinal barrier. Dysbiosis and increased intestinal permeability are observed in several diseases, such as inflammatory bowel disease. Many studies highlight the role
Raffaella di Vito, C. Conte, G. Traina
semanticscholar   +1 more source

Mulberry Anthocyanins Ameliorate DSS-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Modulating Gut Microbiota

Antioxidants, 2022
Mulberry has attracted wide attention due to its substantial nutritional values. This work first studied the protective effect of mulberry anthocyanins (MAS) on dextran sulfate sodium (DSS)-induced colitis. The mice experiment was designed as four groups
Jianling Mo, Jingdan Ni, Ming Zhang, Yang Xu, Yu-ting Li, N. Karim, Wei Chen   +6 more
semanticscholar   +1 more source

Intestinal Barrier Function and Immune Homeostasis Are Missing Links in Obesity and Type 2 Diabetes Development

Frontiers in Endocrinology, 2022
Noncommunicable diseases, such as type 2 diabetes (T2D), place a burden on healthcare systems worldwide. The rising prevalence of obesity, a major risk factor for T2D, is mainly attributed to the adoption of Westernized diets and lifestyle, which cause ...
S. Riedel, C. Pheiffer, Rabia Johnson, J. Louw, C. Muller   +4 more
semanticscholar   +1 more source

Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function

Microorganisms, 2022
Intestinal alkaline phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut.
Gilberto Maia Santos, S. Ismael, J. Morais, J. Araújo, A. Faria, C. Calhau, C. Marques   +6 more
semanticscholar   +1 more source

Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis

Newborn, 2022
Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. NEC is characterized by intestinal tissue inflammation and necrosis. The intestinal barrier is altered in NEC, which potentially contributes to its pathogenesis by promoting intestinal bacterial translocation and stimulating the inflammatory response.
Managlia, Elizabeth, Yan, Xiaocai, De Plaen, Isabelle G   +2 more
openaire   +2 more sources

Intestinal Barrier Function in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Journal of Clinical and Translational Hepatology, 2022
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The mechanisms involved in NAFLD onset are complicated and multifactorial. Recent literature has indicated that altered intestinal barrier function is related to
Lu-qiong Liu, Minyue Yin, Jingwen Gao, Chenyan Yu, Jiaxi Lin, A. Wu, Jinzhou Zhu, Chunfang Xu, Xiaolin Liu   +8 more
semanticscholar   +1 more source

Intestinal Barrier Function in Chronic Kidney Disease [PDF]

Toxins, 2018
The kidneys are key contributors to body homeostasis, by virtue of controlled excretion of excessive fluid, electrolytes, and toxic waste products. The syndrome of uremia equals the altered physiology due to irreversible loss of kidney function that is left uncorrected for, despite therapeutic intervention(s).
Meijers, Bjorn, Farre, Ricard, Dejongh, Sander, Vicario, Maria, Evenepoel, Pieter   +4 more
openaire   +3 more sources