Results 81 to 90 of about 215,029 (331)

Intestinal Mucosal Barrier Is Injured by BMP2/4 via Activation of NF-κB Signals after Ischemic Reperfusion

Mediators of Inflammation, 2014
Intestinal ischemic reperfusion (I/R) can cause dysfunction of the intestinal mucosal barrier; however, the mechanism of the intestinal mucosal barrier dysfunction caused by I/R remains unclear.
Kang Chen, Wei Xie, Binyu Luo, Weidong Xiao, Daniel H. Teitelbaum, Hua Yang, Kebin Zhang, Chaojun Zhang   +7 more
doaj   +1 more source

Intestinal Mucosal Mast Cells: Key Modulators of Barrier Function and Homeostasis

Cells, 2019
The gastrointestinal tract harbours the largest population of mast cells in the body; this highly specialised leukocyte cell type is able to adapt its phenotype and function to the microenvironment in which it resides.
Mercé Albert-Bayo, Irene Paracuellos, Ana M. González-Castro, Amanda Rodríguez-Urrutia, María J. Rodríguez-Lagunas, Carmen Alonso-Cotoner, Javier Santos, María Vicario   +7 more
doaj   +1 more source

PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection. [PDF]

, 2019
Chronic gut inflammatory diseases are associated with disruption of intestinal epithelial barriers and impaired mucosal immunity. HIV-1 (HIV) causes depletion of mucosal CD4+ T cells early in infection and disruption of gut epithelium, resulting in ...
Arredondo, Juan, Cortopassi, Gino, Crakes, Katti R, Dandekar, Satya, Datta, Sandipan, Fenton, Anne, Gaulke, Christopher A, Giulivi, Cecilia, Grishina, Irina, Hirao, Lauren A, Marco, Maria L, Napoli, Eleonora, Sankaran-Walters, Sumathi, Santos Rocha, Clarissa   +13 more
core  

Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy. [PDF]

, 2013
ObjectivesTo examine the impact of serum-derived bovine immunoglobulin, an oral medical food known to neutralize bacterial antigen and reduce intestinal inflammation, on restoration of mucosal immunity and gastrointestinal function in individuals with ...
Albanese, Anthony, Asmuth, David M, Devaraj, Sridevi, Douek, Daniel C, Flynn, Neil M, Garcia, Juan-Carlos, Knight, Thomas H, Ma, Zhong-Min, Miller, Christopher J, Sandler, Netanya G, Tsuchida, Emily, Wu, Tsung-Teh, Yotter, Tammy   +12 more
core   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Estrogen deficiency aggravates fluoride-induced small intestinal mucosa damage and junctional complexes proteins expression disorder in rats

Ecotoxicology and Environmental Safety, 2022
To investigate the effect of estrogen deficiency on the small intestinal mucosal barrier induced by fluoride (F), F exposure models of ovariectomy (OVX) rats (surgically removed ovaries) and non-OVX rats (normal condition) were established by adding ...
Ye Jin, Xiao-ying Gao, Jing Zhao, Wei-shun Tian, Yu-ling Zhang, Er-jie Tian, Bian-hua Zhou, Hong-wei Wang   +7 more
doaj   +1 more source

The Association of Altered Gut Microbiota and Intestinal Mucosal Barrier Integrity in Mice With Heroin Dependence

Frontiers in Nutrition, 2021
The gut microbiota is believed to play a significant role in psychological and gastrointestinal symptoms in heroin addicts. However, the underlying mechanism remains largely unknown. We show here that heroin addicts had a decrease in body mass index (BMI)
Jiqing Yang, Pu Xiong, Ling Bai, Zunyue Zhang, Yong Zhou, Cheng Chen, Zhenrong Xie, Yu Xu, Minghui Chen, Huawei Wang, M. Zhu, Juehua Yu, Kunhua Wang   +12 more
semanticscholar   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Mechanisms of action and applications of Polygonatum sibiricum polysaccharide at the intestinal mucosa barrier: a review

Frontiers in Pharmacology
As a medicinal and edible homologous Chinese herb, Polygonatum sibiricum has been used as a primary ingredient in various functional and medicinal products. Damage to the intestinal mucosal barrier can lead to or worsen conditions such as type 2 diabetes
Yu Ren, Yu Ren, Yi Sun, Yu-Ying Liao, Si Wang, Si Wang, Qian Liu, Chun-Yan Duan, Lan Sun, Xiao-Ya Li, Jia-Li Yuan   +10 more
doaj   +1 more source

Blockade of high-mobility group box 1 attenuates intestinal mucosal barrier dysfunction in experimental acute pancreatitis

Scientific Reports, 2017
The release of inflammatory cytokines, that plays a dominant role in local pancreatic inflammation and systemic complications in severe acute pancreatitis (SAP).
Xia Chen, Hong-Xian Zhao, Chao Bai, Xiang-Yu Zhou   +3 more
doaj   +1 more source