Results 101 to 110 of about 657,043 (287)

Dihydrotanshinone attenuates chemotherapy-induced intestinal mucositis and alters fecal microbiota in mice

Biomedicine & Pharmacotherapy, 2020
Chemotherapy-induced intestinal mucositis (CIM) is a principal reason for reduced living quality of patients undergoing chemotherapy. Growing evidence showed gut microbiota played an important role in the development of intestinal mucositis. Dihydrotanshinone I (DHTS) is a liposoluble extract of Salvia miltiorrhiza Bunge with many bioactivities.
Lin, Wang, Rui, Wang, Guang-Yi, Wei, Shu-Me, Wang, Guan-Hua, Du   +4 more
openaire   +2 more sources

The mucosal firewalls against commensal intestinal microbes [PDF]

, 2009
Mammals coexist with an extremely dense microbiota in the lower intestine. Despite the constant challenge of small numbers of microbes penetrating the intestinal surface epithelium, it is very unusual for these organisms to cause disease.
Macpherson, Andrew J, Slack, Emma, Geuking, Markus B, McCoy, Kathy D   +3 more
core   +2 more sources

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

A new method for extracting skin microbes allows metagenomic analysis of whole-deep skin [PDF]

, 2013
In the last decade, an extensive effort has been made to characterize the human microbiota, due to its clinical and economic interests. However, a metagenomic approach to the skin microbiota is hampered by the high proportion of host DNA that is ...
Francesc Calafell, Koldo Garcia-Etxebarria, Garcia-Etxebarria, Koldo, Marc Garcia-Garcerà (3214074), Mireia Coscollà (149823), Calafell, Francesc, Amparo Latorre (88013), Calafell, Francesca, Garcia-Garcerà, Marc, Koldo Garcia-Etxebarria (461325), Coscollà, Mireia, Marc Garcia-Garcerà, Amparo Latorre, Francesc Calafell (148375), Latorre, Amparo, Mireia Coscollà   +15 more
core   +1 more source

Multifunctional Zinc Glycyrrhizinate‐Integrated Gel for Enhanced Probiotic Delivery and Alleviation of Acute and Spontaneous Colitis

Advanced Science, EarlyView.
Multifunctional oral delivery system—L. reuteri@ZGM—act as both a carrier and therapeutic adjuvant, providing ROS scavenging, and mucin‐interactive properties tailored to the IBD microenvironment. This bioactive gel safeguards L. reuteri from gastric degradation, enhances mucosal adhesion, and promotes long‐term retention at inflamed sites, thereby ...
Mengyun Peng, Xiaochun Chen, Wei Li, Shu Tang, Jun Zhou, Xia Wu, Dan Yuan, Zhongyan Shan, Junfeng Shi   +8 more
wiley   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease

Nature Communications
Disrupted host-microbe interactions at the mucosal level are key to the pathophysiology of IBD. This study aimed to comprehensively examine crosstalk between mucosal gene expression and microbiota in patients with IBD.
Shixian Hu, Arno R. Bourgonje, Ranko Gacesa, Bernadien H. Jansen, Johannes R. Björk, Amber Bangma, Iwan J. Hidding, Hendrik M. van Dullemen, Marijn C. Visschedijk, Klaas Nico Faber, Gerard Dijkstra, Hermie J. M. Harmsen, Eleonora A. M. Festen, Arnau Vich Vila, Lieke M. Spekhorst, Rinse K. Weersma   +15 more
doaj   +1 more source

Analyzing the functionality of the human intestinal microbiota by stable isotope probing [PDF]

, 2010
Key words: gut bacteria, dietary carbohydrates, digestion, RNA-SIP, TIM-2, HITChip, human trial The human gastro-intestinal (GI) tract comprises a series of complex and dynamic organs ranging from the stomach to the distal colon, which harbor immense ...
Kovatcheva, P.P.
core  

Metatranscriptome analysis of the human fecal microbiota reveals subject-specific expression profiles, with genes encoding proteins involved in carbohydrate metabolism being dominantly expressed [PDF]

, 2010
The human gastrointestinal (GI) tract provides home to a complex microbial community, collectively termed microbiota. Although major efforts have been made to describe the diversity and stability of the microbiota, functional studies have been largely ...
Vos, W.M., de, Kleerebezem, M., Smidt, H., Zoetendal, E.G., te Boekhorst, J., Hauke Smidt, Booijink, C.C.G.M., Erwin G. Zoetendal, Carien C. G. M. Booijink, Boekhorst, J., te, Michiel Kleerebezem, Jos Boekhorst, Willem M. de Vos, de Vos, W.M.   +13 more
core   +1 more source

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source