Results 91 to 100 of about 657,043 (287)

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

New insights in gut microbiota and mucosal immunity of the small intestine

Human Microbiome Journal, 2018
Abstract Beyond host genetics, the environment determines microbiota-immunity interactions. Most recent studies have focused on the interconnections between micronutrients, microbial and immune populations. However, the control of the gut oxidative stress and redox status has been neglected.
Million, Matthieu, Tomas, Julie, Wagner, Camille, Lelouard, Hugues, Raoult, Didier, Gorvel, Jean-Pierre   +5 more
openaire   +2 more sources

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

Interactions of intestinal epithelial cells with bacterial extracellular products [PDF]

The enteric microflora represents one of the densest microbial populations in the biological world; as a consequence, the intestinal immune system is constantly exposed to high concentrations of antigenic materials. One of the major frontline defences in
Patten, Daniel
core   +3 more sources

Unraveling piglet gut microbiota dynamics in response to feed additives [PDF]

, 2010
Keywords: GI tract, microbiota, pig, PITChip, weaning The gastrointestinal (GI) tract of pigs is colonized by a dense and metabolically active microbiota, comprising mainly bacteria, that have not only a commensal but a symbiotic (beneficial for both ...
Perez-Gutierrez, O.N.
core  

Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits [PDF]

, 2008
Background: In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, where they
Markku Maki, Korponay-Szabó, Ilma Rita, Korponay-Szabo Ilma R, Lohi, Olli, Ilma R Korponay-Szabo, Katri Haimila, Stenman, Satumarja M., Olli Lohi, Partanen, Jukka, Herbert Wieser, Maki, Markku, Mäki Markku, Lindfors, Katri, Haimila Katri, Paivi Saavalainen, Saavalainen Päivi, Saavalainen, Paivi, Lohi Olli, Stenman, Satumarja M, Partanen Jukka, Kaukinen, Katri, Satumarja M Stenman, Haimila, Katri, Stenman Satumarja M, Wieser Herbert, Katri Kaukinen, Wieser, Herbert, Kaukinen Katri, Korponay-Szabó, Ilma, Katri Lindfors, Jukka Partanen, Lindfors Katri   +31 more
core   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Evaluating the microbial diversity of an in vitro model of the human large intestine by phylogenetic microarray analysis [PDF]

, 2010
A high-density phylogenetic microarray targeting small subunit rRNA (SSU rRNA) sequences of over 1000 microbial phylotypes of the human gastrointestinal tract, the HITChip, was used to assess the impact of faecal inoculum preparation and operation ...
Vos, W.M., de, Heilig, H.G.H.J., Vos, W.M.de, Smidt, H., Mirjana Rajilić-Stojanović, de Vos, Willem M., Rajilic-Stojanovic, M., Rajilić-Stojanović, Mirjana, Koen Venema, Maathuis, A., Hauke Smidt, Maathuis, Annet, Smidt, Hauke, Hans G. H. J. Heilig, Venema, Koen, Willem M. de Vos, Heilig, G.H.J., Annet Maathuis, de Vos, W.M., Heilig, Hans G. H. J., Venema, K.   +20 more
core   +1 more source

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source