Results 81 to 90 of about 657,043 (287)

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

The intestinal mucosa-associated microbiota in IBD-associated arthritis displays lower relative abundance of Roseburia intestinalis

Gut Microbes
The most common extra-intestinal manifestation (EIM) of inflammatory bowel disease (IBD), IBD-associated arthritis (IAA), occurs in 25–40% of patients and can be debilitating.
Madeline Alizadeh, Uni Wong, Bernadette C. Siaton, Michael T. France, Seema A. Patil, Lauren George, Dania Hudhud, Kiran Motwani, William H. Scott, Jean-Pierre Raufman, Erik C. von Rosenvinge, Raymond K. Cross, Jacques Ravel   +12 more
doaj   +1 more source

Mucosal microbiota and metabolome along the intestinal tracts reveals location specific relationship

mSystems, 2018
Abstract Background The intestinal microbiota has been recognized as an important component for maintaining human health. The perturbation to its structure has been implicated in many diseases, such as obesity and cancers.
Yuan, Ce, Graham, Melanie, Staley, Christopher, Subramanian, Subbaya   +3 more
openaire   +4 more sources

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Multi-omics association investigation of the relationship between gut microbiota and the development of colorectal cancer

European Journal of Medical Research
Background The human gut mucosal microbiota is crucially involved in colorectal cancer (CRC) development. However, a comprehensive analysis of host–microbiota interactions remains limited.
Shunying Yu, Fang Zhong, Yuqi Wei, Xinyu Shao, Yuqing Zhou, Yibin Sun, Chunli Zhou, Xiaoyi Kuai   +7 more
doaj   +1 more source

Association of intestinal mucosal barrier function with intestinal microbiota in Spleen-Kidney Yang Deficiency IBS-D mice

Frontiers in Microbiology
BackgroundTo establish and evaluate an IBS-D mouse model with Spleen-Kidney Yang Deficiency, explore the microecological mechanisms of IBS-D, and provide experimental evidence for the clinical diagnosis and treatment of IBS-D with Spleen-Kidney Yang ...
Liwen Li, Liwen Li, Qi Long, Qi Long, Na Deng, Na Deng, Zhoujin Tan, Zhoujin Tan   +7 more
doaj   +1 more source

Microarray analysis and barcoded pyrosequencing provide consistent microbial profiles depending on the source of human intestinal samples [PDF]

, 2011
Large-scale and in-depth characterization of the intestinal microbiota necessitates application of high-throughput 16S rRNA gene-based technologies, such as barcoded pyrosequencing and phylogenetic microarray analysis.
Vos, W.M., de, Bartholomeus van den Bogert, Kleerebezem, M., van den Bogert, B., Michiel Kleerebezem, Willem M. de Vos, Zoetendal, E.G., Bogert, B., van den, de Vos, W.M., Erwin G. Zoetendal   +9 more
core   +1 more source

Luminal and Mucosal Microbiota of the Cecum and Large Colon of Healthy and Diarrheic Horses

Animals, 2020
The aim of this study was to compare the mucosal and luminal content microbiota of the cecum and colon of healthy and diarrheic horses. Marked differences in the richness and in the community composition between the mucosal and luminal microbiota of the ...
Luis G. Arroyo, Laura Rossi, Bruna P Santos, Diego E Gomez, Michael G Surette, Marcio C Costa   +5 more
doaj   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

DNA methylation-associated colonic mucosal immune and defense responses in treatment-naïve pediatric ulcerative colitis [PDF]

, 2014
Inflammatory bowel diseases (IBD) are emerging globally, indicating that environmental factors may be important in their pathogenesis. Colonic mucosal epigenetic changes, such as DNA methylation, can occur in response to the environment and have been ...
Winter, Harland, Szigeti, Reka, Kaplan, Jess L., Harris, R. Alan, Nagy-Szakal, Dorottya, Kellermayer, Richard, Ferry, George D., Opekun, Antone, Bronsky, Jiri, Mir, Sabina A.V., Frank, Eibe   +10 more
core   +1 more source