Results 11 to 20 of about 234,915 (329)

Plasma Metabolic and Lipidomic Fingerprinting of Individuals with Increased Intestinal Permeability

Metabolites, 2022
The dual-sugar intestinal permeability test is a commonly used test to assess changes in gut barrier function. However, it does not identify functional changes and the exact mechanism of damage caused by the increased intestinal permeability.
Rohan M. Shah, Snehal R. Jadhav, Laura Phan, Kelton Tremellen, Cuong D. Tran, David J. Beale   +5 more
doaj   +1 more source

Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability

Scientific Reports, 2021
In this study, the intestinal permeability of metal(loid)s (MLs) such as arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) was examined, as influenced by gut microbes and chelating agents using an in vitro gastrointestinal/Caco-2 cell intestinal ...
Shiv Bolan, Balaji Seshadri, Simon Keely, Anitha Kunhikrishnan, Jessica Bruce, Ian Grainge, Nicholas J. Talley, Ravi Naidu   +7 more
doaj   +1 more source

Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Pharmaceutics, 2020
Sufficient colonic absorption is necessary for all systemically acting drugs in dosage forms that release the drug in the large intestine. Preclinically, colonic absorption is often investigated using the rat single-pass intestinal perfusion model.
David Dahlgren, Maria-Jose Cano-Cebrián, Tobias Olander, Mikael Hedeland, Markus Sjöblom, Hans Lennernäs   +5 more
doaj   +1 more source

Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain Injury. [PDF]

PLoS ONE, 2015
Beta-adrenergic blockade has been hypothesized to have a protective effect on intestinal dysfunction and increased intestinal permeability associated with the epinephrine surge after traumatic brain injury (TBI).Wister rats were subjected to either a ...
Yuhuang Lang, Fengming Fu, Dalong Sun, Chenhui Xi, Fengyuan Chen   +4 more
doaj   +1 more source

Associations between food-specific IgG antibodies and intestinal permeability biomarkers

Frontiers in Nutrition, 2022
Increasing translational evidence suggests that intestinal permeability may be a contributing factor to systemic inflammatory events and numerous pathologies.
Alexandra Adorno Vita, Heather Zwickey, Ryan Bradley, Ryan Bradley   +3 more
doaj   +1 more source

Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal PermeabilitySummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
Background & Aims: Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development.
Jay Luther, John J. Garber, Hamed Khalili, Maneesh Dave, Shyam Sundhar Bale, Rohit Jindal, Daniel L. Motola, Sanjana Luther, Stefan Bohr, Soung Won Jeoung, Vikram Deshpande, Gurminder Singh, Jerrold R. Turner, Martin L. Yarmush, Raymond T. Chung, Suraj J. Patel   +15 more
doaj   +1 more source

Differential effects of TNF (TNFSF2) and IFN-γ on intestinal epithelial cell morphogenesis and barrier function in three-dimensional culture. [PDF]

PLoS ONE, 2011
BackgroundThe cytokines TNF (TNFSF2) and IFNγ are important mediators of inflammatory bowel diseases and contribute to enhanced intestinal epithelial permeability by stimulating apoptosis and/or disrupting tight junctions.
Kati Juuti-Uusitalo, Leon J Klunder, Klaas A Sjollema, Katarina Mackovicova, Ryuichi Ohgaki, Dick Hoekstra, Jan Dekker, Sven C D van Ijzendoorn   +7 more
doaj   +1 more source

The role of the intestinal permeability in the progression of nonalcoholic fatty liver disease in obese children

Gastroenterologìa, 2022
Many studies in recent years have revealed increased intestinal permeability in the non-alcoholic fatty liver disease (NAFLD) development and progression to nonalcoholic steatohepatitis (NASH) and liver fibrosis.
Yu.M. Stepanov, N.Yu. Zavhorodnia, N.O. Zhyhyr   +2 more
doaj   +1 more source

Expanding the utility of the dextran sulfate sodium (DSS) mouse model to induce a clinically relevant loss of intestinal barrier function [PDF]

PeerJ, 2020
Background Inflammatory bowel disease (IBD) is a family of debilitating disorders that affects more than 1 million people in the United States. Many animal studies of IBD use a dextran sulfate sodium (DSS) mouse model of colitis that induces rapid and ...
Kyle E. Cochran, Nicholas G. Lamson, Kathryn A. Whitehead   +2 more
doaj   +2 more sources

Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats

Nutrition & Metabolism, 2010
Background An increase in the intestinal permeability is considered to be associated with the inflammatory tone and development in the obesity and diabetes, however, the pathogenesis of the increase in the intestinal permeability is poorly understood ...
Suzuki Takuya, Hara Hiroshi
doaj   +1 more source