Results 11 to 20 of about 258,180 (266)
Combatting intracellular pathogens using bacteriophage delivery [PDF]
Critical Reviews in Microbiology, 2021 Intracellular pathogens reside in specialised compartments within the host cells restricting the access of antibiotics. Insufficient intracellular delivery of antibiotics along with several other resistance mechanisms weaken the efficacy of current therapies. An alternative to antibiotic therapy could be bacteriophage (phage) therapy.
Avijit, Goswami +2 more
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Exploitation of the Host Ubiquitin System: Means by Legionella pneumophila
Frontiers in Microbiology, 2021 Ubiquitination is a commonly used post-translational modification (PTM) in eukaryotic cells, which regulates a wide variety of cellular processes, such as differentiation, apoptosis, cell cycle, and immunity.
Jingjing Luo +3 more
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A randomized multiplex CRISPRi-Seq approach for the identification of critical combinations of genes
eLife, 2023 Identifying virulence-critical genes from pathogens is often limited by functional redundancy. To rapidly interrogate the contributions of combinations of genes to a biological outcome, we have developed a multiplex, randomized CRISPR interference ...
Nicole A Ellis +7 more
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mBio, 2022 Francisella tularensis, a Tier 1 select agent of bioterrorism, contains a type VI secretion system (T6SS) encoded within the Francisella pathogenicity island (FPI), which is critical for its pathogenesis.
Xiaoyu Liu +5 more
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Q Fever Vaccine Development: Current Strategies and Future Considerations
Pathogens, 2021 Q fever is a zoonotic disease caused by the intracellular pathogen Coxiella burnetii. This disease typically manifests as a self-limiting, febrile illness known as acute Q fever.
Carrie Mae Long
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Brucella: not your ‘typical’ intracellular pathogen [PDF]
Microbiology Australia, 2020 Currently the genus Brucella consists of a group of bacteria that are genetically monospecific yet phenotypically diverse, and a recent genetic and phenotypic divergent group known as ‘atypical' Brucellae.
Nicky Buller, Anthony L Keyburn
doaj
Pathogens, 2023 In 2020, the WHO established the road map for neglected tropical diseases 2021–2030, which aims to control and eradicate 20 diseases, including leishmaniosis and Chagas disease. In addition, since 2015, the WHO has been developing a Global Action Plan on
Sara M. Robledo +7 more
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Frontiers in Cellular and Infection Microbiology, 2016 Intracellular bacterial pathogens replicate within eukaryotic cells and display unique adaptations that support key infection events including invasion, replication, immune evasion, and dissemination.
Punsiri M Colonne +2 more
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Nature Communications, 2023 The bacterium Brucella abortus is an intracellular pathogen that modulates autophagy in host cells. Here, the authors identify two B. abortus effectors that interact with host protease SENP3, thus promoting cytoplasmic accumulation of nucleolar proteins ...
Arthur Louche +15 more
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Pathogenic mechanisms of intracellular bacteria [PDF]
Current Opinion in Infectious Diseases, 2017 Purpose of review We wished to overview recent data on a subset of epigenetic changes elicited by intracellular bacteria in human cells. Reprogramming the gene expression pattern of various host cells may facilitate bacterial growth, survival, and spread.
Niller Hans Helmut +4 more
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