Results 31 to 40 of about 803,683 (201)

Lysosome transport as a function of lysosome diameter. [PDF]

PLoS ONE, 2014
Lysosomes are membrane-bound organelles responsible for the transport and degradation of intracellular and extracellular cargo. The intracellular motion of lysosomes is both diffusive and active, mediated by motor proteins moving lysosomes along ...
Debjyoti Bandyopadhyay, Austin Cyphersmith, Jairo A Zapata, Y Joseph Kim, Christine K Payne   +4 more
doaj   +1 more source

Hitchhiking Through the Cytoplasm [PDF]

, 2006
We propose an alternative mechanism for intracellular cargo transport which results from motor induced longitudinal fluctuations of cytoskeletal microtubules (MT).
Kulić, Igor M., Nelson, Philip C.
core   +3 more sources

Defective axonal transport in motor neuron disease [PDF]

, 2007
Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas, Blair, Boillee, Bommel, Borchelt, Bowling, Brown, Bruijn, Burger, Cao, Cleveland, Cleveland, Duchen, Escurat, Evans, Fichera, Fliegner, Gaudette, Goldstein, Hadano, Hafezparast, Hazan, Hirokawa, Hirokawa, Hirokawa, Jablonka, Joshi, Kanai, Kaplan, Kieran, King, Kong, LaMonte, Levy, Ligon, Liu, Lo Giudice, Lu, Martin, Miki, Miki, Mitsumoto, Mitsumoto, Muglia, Munch, Nicholson, Nishimura, Okabe, Otomo, Parkinson, Parysek, Pasinelli, Patel, Proukakis, Puls, Puls, Quenneville, Rao, Reid, Reid, Reid, Rosen, Ross, Rowland, Sanderson, Schmitt-John, Shaw, Shibata, Siegel, Song, Teuchert, Troy, Vallee, Weber, Williamson, Wood, Xia, Zhao   +77 more
core   +1 more source

Targeted Intracellular Delivery of Antibodies: The State of the Art

Frontiers in Pharmacology, 2018
A dominant area of antibody research is the extension of the use of this mighty experimental and therapeutic tool for the specific detection of molecules for diagnostics, visualization, and activity blocking.
Tatiana A. Slastnikova, A. V. Ulasov, A. A. Rosenkranz, A. A. Rosenkranz, A. S. Sobolev, A. S. Sobolev   +5 more
doaj   +1 more source

Cytoplasmic Flow and Mixing Due to Deformation of Motile Cells. [PDF]

, 2017
The cytoplasm of a living cell is a dynamic environment through which intracellular components must move and mix. In motile, rapidly deforming cells such as human neutrophils, bulk cytoplasmic flow couples cell deformation to the transport and dispersion
Chan, Caleb K, Koslover, Elena F, Theriot, Julie A   +2 more
core   +2 more sources

Effect of the T-domain on intracellular transport of diphtheria toxin [PDF]

The Ukrainian Biochemical Journal, 2014
Subunit B of diphtheria toxin (DT), which consists of two domains: R (receptor-binding) and T (transmembrane), plays an important role in toxin-receptor binding on the cell-targets and in transportation of catalytic subunit A to the cell cytosol ...
А. J. Labyntsev, D. V. Kolybo, E. S. Yurchenko, A. A. Kaberniuk, N. V. Korotkevych, S. V. Komisarenko   +5 more
doaj   +1 more source

Multi-modal transport and dispersion of organelles in narrow tubular cells

, 2017
Intracellular components explore the cytoplasm via active motor-driven transport in conjunction with passive diffusion. We model the motion of organelles in narrow tubular cells using analytical techniques and numerical simulations to study the ...
Koslover, Elena F., Mogre, Saurabh
core   +1 more source

Dynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking

Virulence, 2021
It is now clear that the intercellular transport on microtubules by dynein and kinesin-1 motors has an important role in the replication and spread of many viruses.
Wei Hou, Wenjie Kang, Yangyang Li, Yanke Shan, Shouyu Wang, Fei Liu   +5 more
doaj   +1 more source

An Update on the Interplay between LRRK2, Rab GTPases and Parkinson’s Disease

Biomolecules, 2023
Over the last decades, research on the pathobiology of neurodegenerative diseases has greatly evolved, revealing potential targets and mechanisms linked to their pathogenesis.
Tadayuki Komori, Tomoki Kuwahara
doaj   +1 more source

Optical excitation and detection of neuronal activity [PDF]

, 2017
Optogenetics has emerged as an exciting tool for manipulating neural activity, which in turn, can modulate behavior in live organisms. However, detecting the response to the optical stimulation requires electrophysiology with physical contact or ...
Gillette, Martha, Hu, Chenfei, Kim, Taewoo, Nastasa, Viorel, Popescu, Gabriel, Sam, Richard, Sengupta, Parijat, Shan, Mingguang, Wang, Minqi   +8 more
core   +2 more sources