Andrographolide Modulates Fibrogenic and Oxidative Stress Responses in Human Lung Fibroblasts
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Pulmonary fibrosis is a progressive lung disorder characterized by fibroblast activation and excessive extracellular matrix deposition. Andrographolide (ANDRO) has been reported to attenuate pulmonary fibrosis, but the underlying molecular mechanisms remain incompletely understood.
Yu‐Hsin Tseng +8 more
wiley +1 more source
Corticosteroid Exposure in Chronic Rhinosinusitis and Global Airway Disease: Adrenal and Bone Impact
The Laryngoscope, EarlyView.ABSTRACT Objective To investigate cumulative corticosteroid (CC) burden in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), with or without coexisting asthma (global airway disease, GAD), referred for biologic treatment, and to assess the prevalence of CC‐related comorbidities, including secondary adrenal insufficiency, osteopenia and ...
Christiane Haase +7 more
wiley +1 more source
Unique Features of Nasal Airway and Airflow Improvement Post‐Dupilumab: A Computational Cohort Study
The Laryngoscope, EarlyView.The impact of dupilumab on nasal airway patency and airflow is not uniform. It is more pronounced in the middle and superior, but not inferior meatus. These unique regional changes significantly correlate with and potentially drive the improvement in patient symptoms.
Ahmad Odeh +12 more
wiley +1 more source
Endoscopic Transnasal Apicoectomy for Odontogenic Maxillary Sinusitis
The Laryngoscope, EarlyView.Endoscopic transnasal apicoectomy (ETA) is a novel multidisciplinary technique that combines endoscopic sinus surgery with apicoectomy via a transnasal approach. ETA enables direct access to periapical lesions while preserving the causative tooth. Our initial experience suggests that this minimally invasive approach is safe, feasible, and effective for
Kenta Fukui +7 more
wiley +1 more source
Effect of intranasal breast milk administration on cerebral oxygenation, vital signs, and transition time to full oral feeding in preterm infants: a randomized controlled study. [PDF]
Eur J PediatrYücel A, Küçükoğlu S, Konak M.
europepmc +1 more source
Homogenous Cell Transplantation Trials in Parkinson's Disease: A Systematic Review and Meta‐Analysis
Movement Disorders Clinical Practice, EarlyView.Abstract Background The transplantation of homogenous cells has emerged as an investigational strategy for Parkinson's disease (PD), offering an alternative to symptomatic treatment. Objective We performed a systematic review and meta‐analysis to assess its clinical efficacy and safety.
Nolan Reinisch +4 more
wiley +1 more source
Seeing Invisible Oligomers: Rethinking α‐Synuclein Pathology Through Proximity Ligation Assay
Movement Disorders, EarlyView.Abstract Parkinson's disease (PD) and multiple system atrophy are defined by α‐synuclein (αSYN)‐positive inclusions – Lewy bodies (LBs) and glial cytoplasmic inclusions – yet mounting evidence indicates that these inclusions represent only a fraction of disease‐relevant pathology.
Hiroaki Sekiya +3 more
wiley +1 more source
Intranasal exosome therapy in Coffin-Siris syndrome: Clinical evaluation of three children. [PDF]
Surg Neurol IntEkici B +6 more
europepmc +1 more source
Pediatric Anesthesia, EarlyView.ABSTRACT Background Emergence delirium (ED) is a common complication in pediatric anesthesia. Although intranasal dexmedetomidine (DEX) is widely used, its application is constrained by a slow onset, residual risk of ED in some patients, and risks such as bradycardia and hypotension.
Munder Lateiresh +5 more
wiley +1 more source
Neffy: A latest needle-free epinephrine. [PDF]
Saudi J AnaesthChittoria K, Mukesh A, Sharma A.
europepmc +1 more source