Results 161 to 170 of about 107,310 (319)

Seeing Invisible Oligomers: Rethinking α‐Synuclein Pathology Through Proximity Ligation Assay

open access: yesMovement Disorders, EarlyView.
Abstract Parkinson's disease (PD) and multiple system atrophy are defined by α‐synuclein (αSYN)‐positive inclusions – Lewy bodies (LBs) and glial cytoplasmic inclusions – yet mounting evidence indicates that these inclusions represent only a fraction of disease‐relevant pathology.
Hiroaki Sekiya   +3 more
wiley   +1 more source

Stem cell–mediated neuroplasticity and psychological recovery in cancer survivors: Mechanisms, evidence, and translational challenges

open access: yesPrecision Medical Sciences, EarlyView.
Cancer therapies can trigger neuroinflammation and disrupted neuroplasticity, contributing to cognitive impairment and psychological distress in survivors. Stem cells (NSCs/MSCs) and their extracellular vesicles may restore neural niches via trophic support, immunomodulation, synaptic remodeling, and vascular repair, but require rigorous safety, dosing,
Xinyi Yang
wiley   +1 more source

Intranasal insulin therapy: the clinical realities.

open access: yes, 1995
To evaluate metabolic control and safety parameters (hypoglycaemia frequency and nasal mucosa physiology), 31 insulin-dependent diabetic patients were treated with intranasal insulin at mealtimes for 1 month and with subcutaneous fast-acting insulin at ...
Pedersen, M   +9 more
core  

Is There a Topical Nasal Steroid Spray That Works the Best for Nasal Congestion?

open access: yes
The Laryngoscope, EarlyView.
Benjamin Aunins   +3 more
wiley   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai   +6 more
wiley   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

open access: yesPhytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández   +5 more
wiley   +1 more source

A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children

open access: yes
Background: Procedural sedation and analgesia are commonly used in the Emergency Departments. Despite this common need, there is still a lack of options for adequate and safe analgesia and sedation in children. The objective of this study was to evaluate
Malin Ryd Rinder   +13 more
core   +1 more source

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