Results 1 to 10 of about 2,191,985 (278)
Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs. [PDF]
PLoS ONE, 2020 Intranasal ketamine has recently gained interest in human medicine, not only for its sedative, anaesthetic or analgesic properties, but also in the management of treatment resistant depression, where it has been shown to be an effective, fast acting ...
Lise Vlerick +6 more
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Drug Design, Development and Therapy, 2022 Jinghui Wang,1 Yuhua Zhang,2 Meifeng Zhang,1 Si Sun,1 Yang Zhong,1 Lei Han,1 Yitong Xu,1 Dong Wan,3 Junhui Zhang,4 Huifeng Zhu1 1College of Pharmaceutical Sciences & College of Chinese Medicine, Southwest University, Chongqing, 400715, People’s Republic ...
Wang J +9 more
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Essential Oil-Loaded NLC for Potential Intranasal Administration [PDF]
Pharmaceutics, 2021 Complementary and alternative medicines represent an interesting field of research on which worldwide academics are focusing many efforts. In particular, the possibility to exploit pharmaceutical technology strategies, such as the nanoencapsulation, for the delivery of essential oils is emerging as a promising strategy not only in Italy but also all ...
Angela Bonaccorso +8 more
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Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications
Pharmaceutics, 2023 Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways.
Raquel Taléns-Visconti +4 more
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Intranasal administration of dantrolene increased brain concentration and duration.
PLoS ONE, 2020 Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent.
Jintao Wang +7 more
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Intranasal Administration for Pain: Oxytocin and Other Polypeptides [PDF]
Pharmaceutics, 2021 Pain, particularly chronic pain, remains one of the most debilitating and difficult-to-treat conditions in medicine. Chronic pain is difficult to treat, in part because it is associated with plastic changes in the peripheral and central nervous systems.
Vimala N. Bharadwaj +4 more
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Nanomedicine, 2019 Aim: To improve the drug delivery to the brain with borneol (Bo)-modified solid lipid nanoparticles (SLNs) of pueraria flavones (PTF) via intranasal administration.
Liping Wang +5 more
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Bioavailability of dexmedetomidine after intranasal administration
European Journal of Clinical Pharmacology, 2011 The aim of this proof-of-concept study was to characterize the pharmacokinetics and pharmacodynamics of intranasal dexmedetomidine compared with its intravenous administration in a small number of healthy volunteers.Single doses of 84 μg of dexmedetomidine were given once intravenously and once intranasally to seven healthy men.
Timo Iirola +6 more
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INTRANASAL ADMINISTRATION OF NITROGLYCERIN [PDF]
Anesthesiology, 1979 A. B. Hill +7 more
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Enhanced Bioavailability of Tadalafil after Intranasal Administration in Beagle Dogs
Pharmaceutics, 2018 Tadalafil is an oral selective phosphodiesterase type-5 inhibitor with demonstrated efficacy and safety that is used to treat erectile dysfunction. The purpose of this study is to compare the pharmacokinetic properties of tadalafil after conventional ...
Jeong-Soo Kim, Min-Soo Kim, In-hwan Baek
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