Results 21 to 30 of about 30,763 (263)

In situ Intranasal Delivery Systems: Application Prospects and Main Pharmaceutical Aspects of Development (Review)

Разработка и регистрация лекарственных средств, 2021
Introduction. Intranasal delivery of in situ gel-forming systems is a complex but promising direction. Due to the high cost of developing a new chemical object or genetically engineered modification of biological molecules, pharmaceutical companies are ...
E. O. Bakhrushina, N. B. Demina, M. M. Shumkova, P. S. Rodyuk, D. S. Shulikina, I. I. Krasnyuk   +5 more
doaj   +1 more source

Intranasal Delivery of Morphine

The Journal of Pharmacology and Experimental Therapeutics, 2002
Morphine administered nasally to humans as a simple solution is only absorbed to a limited degree, with a bioavailability of the order of 10% compared with intravenous administration. This article describes the development of novel nasal morphine formulations based on chitosan, which, in the sheep model, provide a highly increased absorption with a 5 ...
L, Illum, P, Watts, A N, Fisher, M, Hinchcliffe, H, Norbury, I, Jabbal-Gill, R, Nankervis, S S, Davis   +7 more
openaire   +2 more sources

Aerosolized In Vivo 3D Localization of Nose-to-Brain Nanocarrier Delivery Using Multimodality Neuroimaging in a Rat Model—Protocol Development

Pharmaceutics, 2021
The fate of intranasal aerosolized radiolabeled polymeric micellar nanoparticles (LPNPs) was tracked with positron emission tomography/computer tomography (PET/CT) imaging in a rat model to measure nose-to-brain delivery.
Michael C. Veronesi, Brian D. Graner, Shih-Hsun Cheng, Marta Zamora, Hamideh Zarrinmayeh, Chin-Tu Chen, Sudip K. Das, Michael W. Vannier   +7 more
doaj   +1 more source

Synthesis of an insulin-loaded mucoadhesive nanoparticle designed for intranasal administration: focus on new diffusion media

Frontiers in Pharmacology, 2023
Intranasal administration is a drug delivery approach to provide a non-invasive pharmacological response in the central nervous system with relatively small peripheral side effects. To improve the residence time of intranasal drug delivery systems in the
Tahereh Jamshidnejad-Tosaramandani, Tahereh Jamshidnejad-Tosaramandani, Tahereh Jamshidnejad-Tosaramandani, Soheila Kashanian, Soheila Kashanian, Isaac Karimi, Helgi B. Schiöth   +6 more
doaj   +1 more source

Intranasal administration of erythropoietin rescues the photoreceptors in degenerative retina: a noninvasive method to deliver drugs to the eye

Drug Delivery, 2019
Inherited retinopathies typically lead to photoreceptor loss and severe visual impairments in the subjects. Intranasal administration is an efficient approach to deliver therapeutic agents to the targeted tissue.
Ye Tao, Chong Li, Anhui Yao, Yingxin Qu, Limin Qin, Zuojun Xiong, Jianbin Zhang, Weiwen Wang   +7 more
doaj   +1 more source

Intranasal Administration of Dolutegravir-Loaded Nanoemulsion-Based In Situ Gel for Enhanced Bioavailability and Direct Brain Targeting

Gels, 2023
Dolutegravir’s therapeutic effectiveness in the management of neuroAIDS is mainly limited by its failure to cross the blood–brain barrier. However, lipid-based nanovesicles such as nanoemulsions have demonstrated their potential for the brain targeting ...
Anroop B. Nair, Sunita Chaudhary, Shery Jacob, Dhwani Patel, Pottathil Shinu, Hiral Shah, Ankit Chaudhary, Bandar Aldhubiab, Rashed M. Almuqbil, Ahmed S. Alnaim, Fatemah Alqattan, Jigar Shah   +11 more
doaj   +1 more source

A promising drug delivery: Intranasal drug delivery system

International Journal of Pharmaceutical Sciences Review and Research, 2021
Pneumonic medication conveyance has acquired gigantic logical interest as of late and has advanced inside the setting of treatment for lung infections. Lung is an appealing climate for bio particles, which are exceptionally presented to enzymatic debasement in the gastrointestinal parcel just as hepatic corruption.
M. Srinivas, Y. Kalyani, J. V. C. Sharma
openaire   +2 more sources

Intranasal Delivery of Collagen-Loaded Neprilysin Clears Beta-Amyloid Plaques in a Transgenic Alzheimer Mouse Model

Frontiers in Aging Neuroscience, 2021
Alzheimer’s disease (AD) is pathologically characterized by extracellular beta-amyloid (Aβ) plaques and intraneuronal tau tangles in the brain. A therapeutic strategy aims to prevent or clear these Aβ plaques and the Aβ-degrading enzyme neprilysin is a ...
Christian Humpel
doaj   +1 more source

Intranasal Administration of N-acetyl-L-cysteine Combined with Cell-Penetrating Peptide-Modified Polymer Nanomicelles as a Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis

Pharmaceutics, 2022
Intranasal administration is a promising route for direct drug delivery to the brain; its combination with nanocarriers enhances delivery. We have previously shown that intranasal administration combined with PEG-PCL-Tat (a nanocarrier) efficiently ...
Takumi Kurano, Takanori Kanazawa, Shingo Iioka, Hiromu Kondo, Yasuhiro Kosuge, Toyofumi Suzuki   +5 more
doaj   +1 more source

Development and Testing of a Spray-Dried Tuberculosis Vaccine Candidate in a Mouse Model

Frontiers in Pharmacology, 2022
Converting a vaccine into a thermostable dry powder is advantageous as it reduces the resource burden linked with the cold chain and provides flexibility in dosage and administration through different routes.
Mellissa Gomez, Mushtaq Ahmed, Shibali Das, Joseph McCollum, Leah Mellett, Rosemary Swanson, Ananya Gupta, Nicholas B. Carrigy, Hui Wang, David Barona, Shital Bachchhav, Alana Gerhardt, Chris Press, Michelle C. Archer, Hong Liang, Emilie Seydoux, Ryan M. Kramer, Philip J. Kuehl, Reinhard Vehring, Shabaana A. Khader, Christopher B. Fox, Christopher B. Fox   +21 more
doaj   +1 more source