Results 121 to 130 of about 22,711 (279)

Targeted Delivery of Drugs by Intranasal Drug Delivery for Alzheimer’s Disease Treatment

Journal of Neonatal Surgery
Alzheimer’s disease (AD) exhibits chronic neuron damaging, characterized by progressive cognitive impairment, memory deterioration, and widespread neuronal destruction, ultimately leading to irreversible brain damage. Current treatments for neurological disorders are hindered by the blood brain barrier’s (BBB) selective permeability, which severely ...
Pulagurtha Bhaskararao, Sujiya Balla, Madhavi Latha Samala, Anu Pravallika Janipalli, Sai Kiran S. S. Pindiprolu, Chirravuri S Phani Kumar   +5 more
openaire   +1 more source

Brain Delivery Strategies for Biomacromolecular Drugs: Intranasal Administration

International Journal of Nanomedicine
Macromolecular Drugs (including monoclonal antibodies, recombinant proteins, and nucleic acid therapies) have become a cornerstone strategy for intervening in complex pathological mechanisms such as cancer, autoimmune diseases, and genetic disorders due to their high specificity for disease targets and low off-target toxicity.
Huanhuan Wu, Chenyu Li, Hong Yuan, Jingyuan Zhao, Shuai Li   +4 more
openaire   +4 more sources

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden, Michael Kelleher, Fiona Dunbar, Anna O. Ermakova, Luke Mitcheson, Claire Roberts, James J. Rucker, Gemma Scott, Ivan Saeger, Francesca Small, Mathieu Seynaeve   +10 more
wiley   +1 more source

Biocompatible Carbon Nanotube-Based Drug Delivery System for Neurodegenerative and Regenerative Biomedical Applications

C
Carbon nanotubes (CNTs) represent promising nanoplatforms for drug delivery due to their high surface area, tunable surface chemistry, and unique physicochemical properties.
Stefano Bellucci
doaj   +1 more source

Brain Targeting by Intranasal Drug Delivery: Effect of Different Formulations of the Biflavone "Cupressuflavone" from Juniperus sabina L. on the Motor Activity of Rats. [PDF]

Molecules, 2023
Khafagy ES, Soliman GA, Shahba AA, Aldawsari MF, Alharthy KM, Abdel-Kader MS, Zaatout HH.   +6 more
europepmc   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Evaluation of the Pharmacokinetics of Intranasal Drug Delivery for Targeting Cervical Lymph Nodes in Rats. [PDF]

Pharmaceutics, 2021
Furubayashi T, Inoue D, Kimura S, Tanaka A, Sakane T.   +4 more
europepmc   +1 more source

Pharmacokinetic studies for the development of transdermal drug delivery systems

, 2007
PhDThis thesis mainly describes a series of Phase I pharmacokinetic studies conducted on the TDS®d elivery systemw hich combinedw ith lidocaine,t estosteronea, nd a new drug, Melanotan-I for the transdermal drug delivery.
Chik, Zamri
core  

Modification of a breast pump suction pattern increases milk yield during the first 4 days postpartum

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Adding 5 min of nutritive suction to a standard pumping protocol significantly increases early milk removal in the first 4 days postpartum. This simple adjustment is particularly effective in the first 2 days, when colostrum volumes are low. Optimizing early pumping strategies may improve access to colostrum and support lactation initiation in mothers ...
Theresia Margaretha Nicole Manshanden, Danielle Kaye Prime, Fedde Scheele, Joost Velzel   +3 more
wiley   +1 more source

Intranasal fentanyl for pain control: current status with a focus on patient considerations

Patient Preference and Adherence, 2011
Eric Prommer, Lisa ThompsonDivision of Hematology/Oncology, Mayo Clinic College of Medicine, Mayo Clinic Hospital, Scottsdale, AZ, USAAbstract: Of several newer delivery systems under development and investigation for the administration of opioids, the ...
Eric Prommer, Lisa Thompson
doaj