Results 161 to 170 of about 22,711 (279)

Intranasal delivery of dimethyl fumarate and monomethyl fumarate using hyaluronic acid-based hybrid nanoparticles to enhance CNS bioavailability

Dimethyl fumarate (DMF) and its active metabolite monomethyl fumarate (MMF) are first-line oral therapies for multiple sclerosis (MS), but their clinical use is limited by gastrointestinal side effects and low bioavailability.
Ferraro, Luca, Cossu, Massimo, Dalpiaz, Alessandro, Rassu, Giovanna, Guarino, Vincenzo, Cruz-Maya, Iriczalli, Giunchedi, Paolo, Serri, Carla, Gavini, Elisabetta, Botti, Giada   +9 more
core   +1 more source

Intranasal Drug Delivery in Neuropharmacology: Advances in Brain-Targeted Therapies and Bioethical Challenges. [PDF]

Biomedicines
Damian SI, David SM, Nour M, Halitchi GL, Ciurlea SA, Stefanache A, Duma OO, Calin G, Spaiuc D.   +8 more
europepmc   +1 more source

Primary Studies on Construction and Evaluation of Ion-Sensitive in situ Gel Loaded with Paeonol-Solid Lipid Nanoparticles for Intranasal Drug Delivery. [PDF]

Int J Nanomedicine, 2020
Sun Y, Li L, Xie H, Wang Y, Gao S, Zhang L, Bo F, Yang S, Feng A.   +8 more
europepmc   +1 more source

Hyaluronic acid-based hybrid nanoparticles for intranasal delivery of dimethyl fumarate

Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease characterized byan abnormal reaction of defenses of the immune system attaking certain nervous system components.
G. Botti, G. Rassu, M. Piccioni, P Giunchedi, A. Dalpiaz, M. P. Di Cagno, V. Guarino, L. Ferraro, E. Gavini, C. Serri, S. Crispi, I. Cruz-Maya   +11 more
core  

Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer’s disease

, 2018
Qingqing Meng,1,* Aiping Wang,1,2,* Hongchen Hua,1 Ying Jiang,1 Yiyun Wang,1 Hongjie Mu,1 Zimei Wu,1 Kaoxiang Sun1 1School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong ...
Jiang Y, Sun KX, Mu HJ, Meng QQ, Wu ZM, Wang YY, Wang AP, Hua HC   +7 more
core  

Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 94-108, July 2026.
Interest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Tijana Stojanović, Kent W. Nilsson, Robert Fredriksson, Helgi B. Schiöth, Thiago C. Moulin   +4 more
wiley   +1 more source

Novel low-cost atomizer design for intranasal drug delivery. [PDF]

J Anaesthesiol Clin Pharmacol
Sinha R, Kumar A, Ayub A.
europepmc   +1 more source

Intranasal delivery of rotigotine to the brain with lactoferrin-modified PEG-PLGA nanoparticles for Parkinson’s disease treatment

, 2016
Chenchen Bi,1,* Aiping Wang,1,* Yongchao Chu,1 Sha Liu,1 Hongjie Mu,1 Wanhui Liu,1 Zimei Wu,1 Kaoxiang Sun,1 Youxin Li1,2 1School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong,
Liu WH, Sun KX, Mu HJ, Chu YC, Wu ZM, Bi CC, Liu S, Wang AP, Li YX   +8 more
core  

Apple Pomace Pectin for Gastroprotective Nutraceutical Delivery: Structure–Function Relationships and Nano/Microencapsulation Strategies for Gastric Ulcer Management

Food Frontiers, Volume 7, Issue 4, July 2026.
Apple pomace pectin is explored as a sustainable and multifunctional biomaterial for gastric ulcer management. Its unique structural features confer mucoadhesive, anti‐inflammatory, antioxidant, and anti‐Helicobacter pylori activities while enabling nano/microencapsulation of therapeutic agents.
Akash Dhiman, Shefali Arora, Parteek Prasher, Sukanya Chhetri, Pankaj Bhandari, William N. Setzer, Javad Sharifi‐Rad   +6 more
wiley   +1 more source

Therapeutic Efficacy of Intranasal N-Acetyl-L-Cysteine with Cell-Penetrating Peptide-Modified Polymer Micelles on Neuropathic Pain in Partial Sciatic Nerve Ligation Mice

Background/Objectives: We previously demonstrated that the intranasal administration of cell-penetrating Tat peptide-modified carrier, PEG-PCL-Tat, improves drug delivery to the central nervous system.
Saia Sakamoto, Ai Takahashi, Taiki Nagatomo, Hiroko Miyagishi, Hiroshi Nango, Yasuhiro Kosuge, Takumi Kurano, Naoto Suzuki, Takanori Kanazawa, Toyofumi Suzuki   +9 more
core   +1 more source