Results 191 to 200 of about 22,711 (279)

Appropriate Medical Therapy Primarily Modifies Type 2 and Severity Biomarkers in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, Volume 16, Issue 6, Page 595-606, June 2026.
ABSTRACT Background Appropriate medical therapy (AMT) is first‐line treatment for patients with chronic rhinosinusitis (CRS). We evaluated inflammatory structure, treatment‐induced changes, and biomarker‐outcome associations in AMT‐managed patients. Methods Fifty‐one CRS patients were evaluated before and after AMT which included a combination of oral ...
Asher C. Park, Brooke N. Gleason, Eli Stein, Saied Ghadersohi, Atsushi Kato, Stephanie Shintani‐Smith, David B. Conley, Kevin C. Welch, Robert C. Kern, Bruce K. Tan   +9 more
wiley   +1 more source

Delivering Proteins and Enzymes to Solid Tumors Through the Development of Stimuli‐Responsive Nanocarriers

ChemNanoMat, Volume 12, Issue 6, June 2026.
Stimuli‐responsive strategies to achieve controlled release of protein‐based therapeutic agents into solid tumors. Proteins, enzymes, and peptides have long been recognized as valuable therapeutic agents, particularly in oncology. However, their complex chemical structures render them more sensitive than smaller chemotherapeutic drugs.
Guillermo Plaza‐Palomo, Diana Benita‐Donadios, Sandra Jiménez‐Falcao, Alejandro Baeza   +3 more
wiley   +1 more source

Progress of Immunotherapies in Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Parkinson's disease (PD) is caused by an immune disorder triggered by α‐synuclein, leading to a persistent neuroinflammatory cycle that drives the disease from non‐motor symptoms to the motor stage. Second, it presents active and passive immunotherapy strategies targeting α‐synuclein and their potential in slowing down the disease progression.
Yong Peng, Xu‐hui Kang, Shun‐yu Yao, Xiuli Zhang, Sugimoto Kazuo, Jia Liu, Miao‐qiao Du, Lan‐xin Lin, Dai‐yi Jiang, Quan Chen, Hong Jin   +10 more
wiley   +1 more source

Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni, Patrick Belvitch, Steven M. Dudek, Eleftheria Letsiou   +3 more
wiley   +1 more source

Modeling Supports Combinatorial Effects Between Pharmacological and Non‐Pharmacological Interventions to Prevent Opioid‐Induced Cardiac Arrest

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1466-1475, June 2026.
Few studies have quantified the effects of non‐pharmacological interventions (e.g., rescue breathing) in the setting of community opioid overdose. We extended a previously validated model for opioid antagonists by incorporating the mechanism of rescue breathing, and quantified combinatorial effects between rescue breathing and various formulations of ...
Bradlee Thrasher, John Mann, Anik Chaturbedi, Shilpa Chakravartula, Hamed Meshkin, Affan Affan, Alexander Galluppi, Ji Young Kim, Nigar Karimli, Yue Han, Zachary Dezman, Jeffry Florian, Zhihua Li   +12 more
wiley   +1 more source

Multi‐omics reveals a novel Cxcr4+ subpopulation of alveolar macrophages and therapeutic effect of AMD3100 in mice with advanced silicosis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
The progression of silicosis‐associated fibrosis relies on a positive feedback loop mediated by crosstalk between Cxcr4+ macrophages and Cxcl12+ fibroblasts and the therapeutic potential of targeting the Cxcl12/Cxcr4 axis with AMD3100 as a novel strategy for treating silicosis.
Min Mu, Bing Li, Hangbing Cao, Yuanjie Zou, Ruiqing Yan, Fei Wang, Yehong Zhao, Zihao Xie, Miaomiao Du, Xiaolong Wu, Xinrong Tao, Jianhua Wang   +11 more
wiley   +1 more source

Spatial and Phenotypic Heterogeneity of ILC Subsets in Mouse Lung Under Type 2 Inflammatory Conditions

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Using cyclic multiplex microscopy in an IL‐33‐driven type 2 inflammation model, we validated a spatial workflow mapping rare lung ILCs. High‐dimensional analysis revealed a conserved peri‐lymphatic niche at early time points of inflammation where ILC2s and myeloid cells co‐localize with LYVE1+ vessels, highlighting a structured immunological ...
Sandy Kroh, Anna Pascual‐Reguant, Artür Manukyan, Ralf Uecker, Robert Günther, Lars Philipsen, Ralf Koehler, Peggy Mex, Markus Landthaler, Raluca A. Niesner, Anja E. Hauser   +10 more
wiley   +1 more source

Validation and Application of an HPLC–UV Method for the Quantification of 3‐O‐Methylquercetin in Nasal Mucosa

ELECTROPHORESIS, Volume 47, Issue 6, Page 479-488, June 2026.
This study improved an HPLC–UV method for quantifying 3‐O‐methylquercetin in porcine nasal mucosa following ICH M10 and ANVISA (Brazil) guidelines, assessing selectivity, linearity, accuracy, precision, and robustness. The method was applied for the first time to evaluate release, permeation, and retention profiles of a nasal formulation.
Jeniffer Viviana Ramirez Hernández, Laura da Silva Machado, Flávia Nathiely Silveira Fachel, Sara Elis Bianchi, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +6 more
wiley   +1 more source

Butyrylated Starch Attenuates Antibiotic‐Exacerbated Allergic Rhinitis by Restoring the Gut Microbiota and Barrier Function in Mice

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Vancomycin‐induced gut dysbiosis depletes butyrate‐producing bacteria, reduces colonic butyrate, disrupts the intestinal barrier, and exacerbates allergic rhinitis (AR). The colon‐targeted butyrate precursor butyrylated starch reverses this pathological cascade, restores immune homeostasis, and alleviates AR, providing a novel dietary intervention for ...
Yuxi Lin, Qingqing Xu, Siyi Tang, Jingmin Chen, Xing Lin, Yang Liu, Yuanteng Xu   +6 more
wiley   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, Volume 2, Issue 2, June 2026.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source