Results 211 to 220 of about 22,711 (279)

Locoregional Delivery of miRNAs for Glioblastoma Treatment: A Systematic Review of Advances in Delivery Systems. [PDF]

Pharmaceutics
Priya Dharshini LC, Gaiamova E, Serreau R, Garcion E, Morisset-Lopez S, Baril P.   +5 more
europepmc   +1 more source

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley   +1 more source

Multimodal phototherapy for Glioblastoma: from mechanistic action to synergistic delivery and therapeutic strategies. [PDF]

J Nanobiotechnology
Naik GARR, Datta D, Kudarha R, Prajapati B, Patel M, Srinivasan V, Dhas N.   +6 more
europepmc   +1 more source

Efficacy and Safety of Dexmedetomidine‐Esketamine Versus Dexmedetomidine Alone as Premedication for Pediatric Anesthesia Induction: A Systematic Review, Meta‐Analysis, and Trial Sequential Analysis

Pediatric Anesthesia, Volume 36, Issue 6, Page 617-627, June 2026.
ABSTRACT Background Emergence delirium (ED) is a common complication in pediatric anesthesia. Although intranasal dexmedetomidine (DEX) is widely used, its application is constrained by a slow onset, residual risk of ED in some patients, and risks such as bradycardia and hypotension.
Munder Lateiresh, Alhasan Altayf, Ayham Qatza, Abubaker Alghazal, Hasan Al‐sakkaf, Muhammed Elhadi   +5 more
wiley   +1 more source

Intranasal vs. Device-Assisted Drug Delivery: Advantages and Limitations for the Delivery of Biopharmaceuticals to the CNS. [PDF]

Pharmaceutics
De Martini LB, Valori CF, Morrone M, Brambilla L, Rossi D.   +4 more
europepmc   +1 more source

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

Phytotherapy Research, Volume 40, Issue 6, Page 3354-3368, June 2026.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo, Cristiana Lucia Rita Lipari, Aurora Patti, Maria Angela Sortino   +3 more
wiley   +1 more source

Nanoparticle-Based Targeted Drug Delivery Systems for Allergic Rhinitis: A Comprehensive Review. [PDF]

Int J Nanomedicine
Wang Y, Zhou Y, Liang B, Li S, Wang Z, Yan X, Gao Y, Li T, Qin Q, Yang S, Guo F, Nie J.   +11 more
europepmc   +1 more source

Human iPSC‐NSC‐Derived Extracellular Vesicles Can Alleviate Alzheimer's Disease‐Linked Impairments in Mitochondria, mTOR Signaling, Autophagy, and Hippocampal Neurogenesis

Aging Cell, Volume 25, Issue 6, June 2026.
Intranasal administration of extracellular vesicles derived from human‐induced pluripotent stem cell‐derived neural stem cells in 5xFAD mice results in reduced oxidative stress, increased expression of proteins and genes associated with mitochondrial biogenesis and electron transport chain function, decreased mTOR activation, enhanced autophagy and ...
Leelavathi N. Madhu, Sahithi Attaluri, Sanya Kotian, Raghavendra Upadhya, Yogish Somayaji, Shama Rao, Prashant Tarale, Shruthi V. Ganesh, Charles Huard, Maheedhar Kodali, Bing Shuai, Vidya V. Rao, Ashok K. Shetty   +12 more
wiley   +1 more source

Nanostructured Lipid Carriers Loaded with Donepezil for Nose-to-Brain Targeting. [PDF]

Pharmaceutics
Souza IFF, Placido RV, Placido MJ, Rocha LC, Bonfilio R, Boralli VB, Ruela ALM, Pereira GR.   +7 more
europepmc   +1 more source