Results 111 to 120 of about 158,913 (343)

Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice [PDF]

, 2018
Elevated N-methyl-D-aspartate receptor (NMDAR) activity is linked to central sensitization and chronic pain. However, NMDAR antagonists display limited therapeutic potential because of their adverse side effects. Novel approaches targeting the NR2B-PSD95-
Chawla, Aarti, Courtney, Michael J., Hohmann, Andrea G., Hudmon, Andy, Lai, Yvonne Y., Lee, Wan-Hung, Li, Li-Li   +6 more
core   +1 more source

Comparative study of intrathecal bupivacaine in combination with nalbuphine and bupivacaine for subarachnoid block in a tertiary care hospital [PDF]

Journal of Research in Clinical Medicine
Introduction: Various adjuvant therapies have been developed to prolong intra and postoperative analgesia. A comparative study was conducted to evaluate the onset, maximum level, and duration of motor and sensory block, as well as the duration of ...
Lavanya Bachula, Nallolla Rahul Dev, P.V. Shiva, Sunil Kumar Cherukuri   +3 more
doaj   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain

Acta Radiologica Open, 2015
Recently, the “glymphatic system” of the brain has been discovered in rodents, which is a paravascular, transparenchymal route for clearance of excess brain metabolites and distribution of compounds in the cerebrospinal fluid.
P. Eide, G. Ringstad
semanticscholar   +1 more source

Comparative study of different doses of clonidine as an adjuvant with isobaric levobupivacaine for spinal anaesthesia in patients undergoing caesarean section

Journal of Obstetric Anaesthesia and Critical Care, 2019
Background: Various techniques of central neuraxial blockade have been tried and successfully used for caesarean section surgeries. Nowadays it is must and essential to know the possible effective dose of clonidine to overcome its known side effect like ...
Neha Maheshwari, Shefali Gautam, Rajni Kapoor, Ravi Prakash, Shobhna Jafa, Rajni Gupta   +5 more
doaj   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Intrathecal catheter implantation decreases cerebrospinal fluid dynamics in cynomolgus monkeys [PDF]

, 2020
Mohammad Reza Khani, Audrey Qiuyan Fu, Joshua Pluid, Christina P. Gibbs, John N. Oshinski, Tao Xing, Gregory R. Stewart, Jillynne R. Zeller, Bryn A. Martin   +8 more
openalex   +1 more source

Analgesic efficacy and risk of low-to-medium dose intrathecal morphine in patients undergoing cardiac surgery: An updated meta-analysis [PDF]

, 2022
I‐Wen Chen, Cheuk‐Kwan Sun, Ching‐Chung Ko, Pei‐Han Fu, I‐Chia Teng, Weicheng Liu, Chien‐Ming Lin, Kuo‐Chuan Hung   +7 more
openalex   +1 more source

Comparing the effects of intrathecal and intra-articular magnesium sulfate and fentanyl on pain after knee arthroscopy; double-blind clinical trial

The Indian Anaesthetists' Forum
Objectives: The aim of this study was to compare the effects of intrathecal and intra-articular magnesium sulfate (IA-Mg) and fentanyl on pain after knee arthroscopy (KA). Materials and Methods: This double-blind clinical trial was conducted in 2022–2023.
Houriye Safaripoor, Hesameddin Modir, Alireza Susanabadi, Seyed Yosef Shahtaheri, Mohsen Parsi Khamene   +4 more
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source