Results 161 to 170 of about 158,913 (343)

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Benefits of using intrathecal buprenorphine [PDF]

, 2014
Background: General anesthesia draws attention to the most commonly used modalities for post cesarean delivery pain relief in systemic administration of opioids, while the administration of small dose of intrathecal opioid during spinal anesthesia can be
Alijanpour, E., Jabbari, A., Rabiee, S.M., Rostami, S.   +3 more
core  

Paraplegia following intrathecal methotrexate.Report of a case and review of the literature [PDF]

, 1976
Robert G. Gagliano, John J. Costanzi
openalex   +1 more source

Comparative study between the effect of intravenous or intrathecal dexmedetomidine on bupivacaine spinal block in lower abdominal surgery

Al-Azhar Assiut Medical Journal
Background and aim Dexmedetomidine has been shown to prolong spinal anesthesia and enhance postoperative analgesia when given intravenously or intrathecally.
Hayam S. Soliman, Ezzat M.A. Al-Saudi, Ahmed A. Mansour   +2 more
doaj   +1 more source

Rolipram-Loaded PgP Nanotherapeutics via Intrathecal Administration Reduces Secondary Injury in a Rat Acute Moderate Contusion SCI Model. [PDF]

J Neurosci Res
The biodistribution of DiR‐PgP and the therapeutic efficacy of Rm‐PgP after intrathecal administration was investigated in a rat moderate thoracic contusion SCI model. Intrathecal administration of DiR‐PgP showed CNS‐specific retention without peripheral distribution.
Liao Z, Gao J, Khang MK, Webb K, Detloff MR, Lee JS.   +5 more
europepmc   +2 more sources

Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice. [PDF]

, 2019
Approximately 15-40% of all cancers develop metastases in the central nervous system (CNS), yet few therapeutic options exist to treat them. Cancer therapies based on monoclonal antibodies are widely successful, yet have limited efficacy against CNS ...
Chen, Irvin SY, Guan, Xin, Kamata, Masakazu, Kranz, Emiko, Lee, YooJin, Liu, Chaoyong, Liu, Yang, Lu, Yunfeng, Martinez-Maza, Otoniel, Qin, Meng, Sun, Guibo, Sun, Xiaobo, Vinters, Harry V, Wang, Lan, Wen, Jing, Widney, Daniel, Wu, Di, Xu, Duo   +17 more
core  

Transient 7‐hour coma following a sacrococcygeal epidural with ropivacaine in a cat

Veterinary Record Case Reports, EarlyView.
Abstract A 2‐year‐old cat was anaesthetised for pelvic fracture repair. Premedication included methadone 0.2 mg/kg and medetomidine 5 µg/kg intravenously (IV). Anaesthesia was induced with ketamine 2 mg/kg and propofol 1 mg/kg IV and maintained with isoflurane.
Morgane Gavet, Camille Dartencet, Morgane Debuigne, Céline Pouzot‐Nevoret, Stéphane Junot   +4 more
wiley   +1 more source

Spasmodic Dysphonia

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Spasmodic dysphonia is a laryngeal dystonia that can present as adductor, abductor, or mixed types, with or without tremor. The etiology is not understood fully. Comprehensive evaluation is required to establish the diagnosis. Treatments include voice therapy, medications, botulinum toxin injection, laryngeal surgery, deep brain stimulation ...
Aaron J. Jaworek, Robert T. Sataloff
wiley   +1 more source

Intrathecal morphine pretreatment ameliorated hepatic ischemia-reperfusion injury by reducing inflammation through peripheral and spinal opioid activation in rats

, 2020
Yuan Wang, Jueying Liu, Yifeng Qu, Yinghui Fan, Weifeng Yu   +4 more
openalex   +1 more source

A critical review of management of allogeneic transplant‐eligible adults with Ph+ acute lymphoblastic leukaemia

British Journal of Haematology, EarlyView.
Proposed management of newly diagnosed Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukaemia (ALL) in transplant‐eligible patients. Suggested considerations when deciding the treatment pathway available to a newly diagnosed Ph+ ALL patient that would be deemed transplant eligible. Summary Acute lymphoblastic leukaemia (ALL) in 20%–30% of
Naranie Shanmuganathan, Andrew Grigg
wiley   +1 more source