Results 11 to 20 of about 119,000 (243)

Treatments for spasticity and pain in multiple sclerosis: a systematic review [PDF]

, 2003
Objectives: To identify the drug treatments currently available for the management of spasticity and pain in multiple sclerosis (MS), and to evaluate their clinical and cost-effectiveness.
Beard, S.M., Hunn, A., Wight, J.
core   +1 more source

Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. [PDF]

, 2016
Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silencing or upregulation in the central nervous system has been limited by the inability to provide more than limited deep parenchymal expression in adult ...
Ahrens, Eric T, Ciacci, Joseph, Cleveland, Don, Curtis, Erik, Gabel, Brandon, Hruska-Plochan, Marian, Juhas, Stefan, Juhasova, Jana, Kamizato, Kota, Kaspar, Brian K, Lukacova, Nada, Marsala, Martin, Marsala, Silvia, Miyanohara, Atsushi, Navarro, Michael   +14 more
core   +3 more sources

Mas-related G-protein–coupled receptors inhibit pathological pain in mice [PDF]

, 2010
An important objective of pain research is to identify novel drug targets for the treatment of pathological persistent pain states, such as inflammatory and neuropathic pain.
Altier, Baron, Basbaum, Cai, Calignano, Callaghan, Caterina, Chen, Chen, Coderre, Costigan, Costigan, D. J. Anderson, De Felipe, Delmas, Dong, Gerevich, Guan, Guan, Herrero, Honan, Ikeda, Julius, Knabl, Kusudo, Lembo, Li, Li, Liu, Liu, Lu, MacDermott, MacPherson, Malmberg, Melzack, Melzack, Miraucourt, Ndong, Neumann, Q. Liu, Rau, Rodriguez Parkitna, S. N. Raja, Scholz, Seal, Woolf, X. Dong, Y. Guan, Z. Tang, Zeng   +49 more
core   +2 more sources

Current evidence for treatment with nusinersen for spinal muscular atrophy : a systematic review [PDF]

, 2019
Recent discovery of nusinersen, an antisense oligonucleotide drug, has provided encouragement for improving treatment of spinal muscular atrophy. No therapeutic options currently exist for this autosomal recessive motor neuron disorder.
Meylemans, Antoon, De Bleecker, Jan
core   +1 more source

Intrathecal Pumps [PDF]

Neurotherapeutics, 2008
Direct neuroaxis drug delivery has expanded the physician's armamentarium to provide treatment options to those who have failed more conservative interventions. Starting from Bier's 'cocainization of the spinal cord' in 1898, direct nervous system pharmacy delivery has long been recognized as an effective means to treat pain.
Shawn, Belverud, Alon, Mogilner, Michael, Schulder   +2 more
openaire   +2 more sources

Acute pain management after kidney transplantation: A current review of literature

Indian Journal of Transplantation, 2023
Acute postoperative pain management after kidney transplantation is essential for early recovery and good patient satisfaction, but no formal review or guideline is available in the literature.
Vipin Kumar Goyal, Sony Mandal, Ganesh Ramaji Nimje, Praveenkumar Shekhrajka, Pankaj Singh Rana, Saurabh Mittal   +5 more
doaj   +1 more source

Stage progression and neurological symptoms in Trypanosoma brucei rhodesiense sleeping sickness: role of the CNS inflammatory response [PDF]

, 2012
Background: Human African trypanosomiasis progresses from an early (hemolymphatic) stage, through CNS invasion to the late (meningoencephalitic) stage.
A Hainard, B Beutler, B Courtioux, B Namangala, CA Hunter, CA Hunter, CF Calvo, EN Benveniste, F Checchi, F Esamai, G Binz, H Reiber, H Reiber, H Reiber, Hansotto Reiber, HY Hassan, J Kabore, J Rodgers, Jeremy M. Sternberg, JM Sternberg, JM Sternberg, JM Sternberg, Joseph Mathu Ndung'u, KW Moore, L Maclean, L MacLean, L MacLean, L MacLean, LJ Morrison, LM MacLean, Lorna MacLean, M Sjogren, MC Okomo-Assoumou, P Cattand, PD Eckersall, Peter G. E. Kennedy, PG Kennedy, PGE Kennedy, PGE Kennedy, TN Baral, V Jamonneau, V Lejon, V Lejon, V Lejon, W Masocha   +44 more
core   +4 more sources

Computed Tomography-Derived Occipital–Coccygeal Length and Ilium Wing Distance Correlates with Skin to Epidural and Intrathecal Depths in Dogs

Veterinary Sciences, 2020
The current clinical techniques for neuraxial needle placement in dogs are predominantly blind without prior knowledge of the depth required to reach the desired space.
Tsim Christopher Sun, Mariano Makara, Fernando Martinez-Taboada   +2 more
doaj   +1 more source

Antinociceptive Effects of Intrathecal Landiolol Injection in a Rat Formalin Pain Model [PDF]

, 2012
Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents.
Itano, Yoshitaro, Kaku, Ryuji, Kanzaki, Hirotaka, Matsuoka, Yoshikazu, Mizobuchi, Satoshi, Morita, Kiyoshi, Nishie, Hiroyuki, Obata, Norihiko, Ouchida, Mamoru, Taniguchi, Arata, Tomotsuka, Naoto   +10 more
core   +1 more source

Comparative study of two doses of intrathecal dexmedetomidine as adjuvant with low dose hyperbaric bupivacaine in ambulatory perianal surgeries: A prospective randomised controlled study

Indian Journal of Anaesthesia, 2015
Background and Aims: Dexmedetomidine (DMT), as intrathecal adjuvant has been shown to successfully prolong duration of analgesia but delay the motor recovery.
K Sudheesh, R S Raghavendra Rao, M Kavya, J Aarthi, D Devika Rani, S S Nethra   +5 more
doaj   +1 more source