Results 11 to 20 of about 53,357 (145)

Pre-clinical delivery of gene therapy products to the cerebrospinal fluid: challenges and considerations for clinical translation

Frontiers in Molecular Neuroscience, 2023
While the majority of gene therapy studies in neurological indications have focused on direct gene transfer to the central nervous system (CNS), there is growing interest in the delivery of therapeutics using the cerebrospinal fluid (CSF) as a conduit ...
Ernesto A. Salegio, Kelli Hancock, Stephanie Korszen   +2 more
doaj   +1 more source

Intrathecal Pumps [PDF]

Neurotherapeutics, 2008
Direct neuroaxis drug delivery has expanded the physician's armamentarium to provide treatment options to those who have failed more conservative interventions. Starting from Bier's 'cocainization of the spinal cord' in 1898, direct nervous system pharmacy delivery has long been recognized as an effective means to treat pain.
Shawn, Belverud, Alon, Mogilner, Michael, Schulder   +2 more
openaire   +2 more sources

Antinociceptive drug interaction between intrathecal vitamin E and gabapentin in the rat formalin test [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundGabapentin is thought to exert an effect through the voltage-dependent calcium channel. Vitamin E is a widely known antioxidant which neutralizes the harmful effect of ROS which is considered to play a prominent role in various painful ...
Myoung-Joong Kim, Won Hyung Lee, Young-Kwon Ko, Boo Hwi Hong   +3 more
doaj   +1 more source

Spinal GABA transporter 1 contributes to evoked-pain related behavior but not resting pain after incision injury

Frontiers in Molecular Neuroscience, 2023
The inhibitory function of GABA at the spinal level and its central modulation in the brain are essential for pain perception. However, in post-surgical pain, the exact mechanism and modes of action of GABAergic transmission have been poorly studied ...
Bruno Pradier, Daniel Segelcke, Sylvia Reichl, P. K. Zahn, E. M. Pogatzki-Zahn   +4 more
doaj   +1 more source

AAV-mediated gene transfer to colon-innervating primary afferent neurons

Frontiers in Pain Research, 2023
Investigation of neural circuits underlying visceral pain is hampered by the difficulty in achieving selective manipulations of individual circuit components.
Reshma Gore, Tina Esmail, Kelsey Pflepsen, Ezequiel Marron Fernandez de Velasco, Kelley F. Kitto, Maureen S. Riedl, Andrea Karlen, R. Scott McIvor, Christopher N. Honda, Carolyn A. Fairbanks, Carolyn A. Fairbanks, Carolyn A. Fairbanks, Lucy Vulchanova   +12 more
doaj   +1 more source

Computed Tomography-Derived Occipital–Coccygeal Length and Ilium Wing Distance Correlates with Skin to Epidural and Intrathecal Depths in Dogs

Veterinary Sciences, 2020
The current clinical techniques for neuraxial needle placement in dogs are predominantly blind without prior knowledge of the depth required to reach the desired space.
Tsim Christopher Sun, Mariano Makara, Fernando Martinez-Taboada   +2 more
doaj   +1 more source

Comparative study of two doses of intrathecal dexmedetomidine as adjuvant with low dose hyperbaric bupivacaine in ambulatory perianal surgeries: A prospective randomised controlled study

Indian Journal of Anaesthesia, 2015
Background and Aims: Dexmedetomidine (DMT), as intrathecal adjuvant has been shown to successfully prolong duration of analgesia but delay the motor recovery.
K Sudheesh, R S Raghavendra Rao, M Kavya, J Aarthi, D Devika Rani, S S Nethra   +5 more
doaj   +1 more source

The potencies and neurotoxicity of intrathecal levobupivacaine in a rat spinal model: Effects of concentration

Pharmacology Research & Perspectives, 2023
This study was aimed at examining the anesthetic effects and spinal cord injuries in the rats by intrathecal injection of levobupivacaine at different concentrations.
Luyue Gao, Zhen Yang, Sisi Zeng, Jiabei Li, Na Wang, Fangjun Wang   +5 more
doaj   +1 more source

Chronic Enzyme Replacement to the Brain of a Late Infantile Neuronal Ceroid Lipofuscinosis Mouse Has Differential Effects on Phenotypes of Disease

Molecular Therapy: Methods & Clinical Development, 2017
Late infantile neuronal ceroid lipofuscinosis (LINCL) is a fatal inherited neurodegenerative disease caused by loss of lysosomal protease tripeptidyl peptidase 1 (TPP1).
Jennifer A. Wiseman, Yu Meng, Yuliya Nemtsova, Paul G. Matteson, James H. Millonig, Dirk F. Moore, David E. Sleat, Peter Lobel   +7 more
doaj   +1 more source

Preoperative topical intranasal fluorescein in diagnosis of cerebrospinal fluid rhinorrhea

Archives of Trauma Research, 2018
Background and Objectives: The preoperative diagnosis of cerebrospinal fluid (CSF) leak site is necessary for the management of CSF rhinorrhea. At present, intrathecal fluorescein is a common approach for it; however, regarding drawbacks, its value is ...
Seyed Mostafa Hashemi Jazi, Zhale Amini, Masih Saboori, Mostafa Raisi   +3 more
doaj   +1 more source