Results 251 to 260 of about 74,181 (306)
Some of the next articles are maybe not open access.
Physical Medicine and Rehabilitation Clinics of North America, 2022
Intrathecal drug delivery systems are a well-established intervention for chronic pain. The localized delivery of analgesics allows for reduced side effect profiles and pain scores in patients with chronic pain. Given their proven benefits and the development of novel intrathecal medications, intrathecal drug delivery systems are being used earlier in ...
Lynn Kohan
exaly +3 more sources
Intrathecal drug delivery systems are a well-established intervention for chronic pain. The localized delivery of analgesics allows for reduced side effect profiles and pain scores in patients with chronic pain. Given their proven benefits and the development of novel intrathecal medications, intrathecal drug delivery systems are being used earlier in ...
Lynn Kohan
exaly +3 more sources
Critical Reviews in Oncology/Hematology, 2001
An unforeseen consequence of improved disease-free survival in many hematologic and solid tumor malignancies has been an increase in the incidence of disease recurrence in the leptomeninges. The recognition of the central nervous system (CNS) as a unique 'sanctuary' site has resulted in the development of therapeutic strategies specifically directed at
J Z, Kerr, S, Berg, S M, Blaney
openaire +2 more sources
An unforeseen consequence of improved disease-free survival in many hematologic and solid tumor malignancies has been an increase in the incidence of disease recurrence in the leptomeninges. The recognition of the central nervous system (CNS) as a unique 'sanctuary' site has resulted in the development of therapeutic strategies specifically directed at
J Z, Kerr, S, Berg, S M, Blaney
openaire +2 more sources
Medical Clinics of North America, 2007
Since the first use of intrathecal (IT) drug infusion systems in the early 1980s, these delivery systems have undergone numerous revisions making them more tolerable, easier to program, and longer lasting. Concurrent with technological advances, the indications for IT pump placement have also been continuously evolving, to the point where the most ...
Steven P, Cohen, Anthony, Dragovich
openaire +3 more sources
Since the first use of intrathecal (IT) drug infusion systems in the early 1980s, these delivery systems have undergone numerous revisions making them more tolerable, easier to program, and longer lasting. Concurrent with technological advances, the indications for IT pump placement have also been continuously evolving, to the point where the most ...
Steven P, Cohen, Anthony, Dragovich
openaire +3 more sources
Current Opinion in Anaesthesiology, 2002
Development of new drugs and special techniques, as well as changes in health care organization have markedly influenced the use of spinal block and its indications. The present review overviews recent developments in local anesthetic drugs, side effects and special techniques for intrathecal anesthesia.Severe complications after spinal anesthesia are ...
Andrea, Casati, Federico, Vinciguerra
openaire +2 more sources
Development of new drugs and special techniques, as well as changes in health care organization have markedly influenced the use of spinal block and its indications. The present review overviews recent developments in local anesthetic drugs, side effects and special techniques for intrathecal anesthesia.Severe complications after spinal anesthesia are ...
Andrea, Casati, Federico, Vinciguerra
openaire +2 more sources
Neurosurgery Clinics of North America, 2004
Although the use of opioids for intrathecal anesthesia was first reported in 1901, it was not until 25 years ago that the first report of selective blockade of pain by spinal opioids was described. Since its beginning, the promise of selective analgesics derived from intraspinal administration has generated much development in the field of pain ...
Kimberly M, Kaplan, William G, Brose
openaire +2 more sources
Although the use of opioids for intrathecal anesthesia was first reported in 1901, it was not until 25 years ago that the first report of selective blockade of pain by spinal opioids was described. Since its beginning, the promise of selective analgesics derived from intraspinal administration has generated much development in the field of pain ...
Kimberly M, Kaplan, William G, Brose
openaire +2 more sources
Intrathecal Leucovorin After Intrathecal Methotrexate Overdose
Journal of Pediatric Hematology/Oncology, 1996Intrathecal methotrexate is a standard and important therapy in acute leukemia. Unfortunately, overdose is a well reported complication of this therapy. We report a fatal event secondary to intrathecal leucovorin.An 11-year-old boy with a 6-month history of treatment of acute lymphocytic leukemia received an "overdose" of 20 mg of intrathecal ...
L F, Jardine, L C, Ingram, W A, Bleyer
openaire +2 more sources
Epidural, Intrathecal Pharmacokinetics, and Intrathecal Bioavailability of Ropivacaine
Anesthesia & Analgesia, 2007Ropivacaine is used by the epidural route for postoperative pain management with various neuraxial techniques. Given the widespread use of these techniques and the relative paucity of data on spinal disposition of local anesthetics, we evaluated through an experimental animal model, the spinal disposition of ropivacaine, allowing further studies of ...
François-Xavier, Rose +9 more
openaire +2 more sources
THE DANGERS OF INTRATHECAL MEDICATION
JAMA: The Journal of the American Medical Association, 1949The intrathecal space is so frequently chosen for the administration of serums, drugs, antibiotics and anesthetic agents that it is sometimes forgotten that numerous serious and tragic sequelae have been reported following the use of this route. It therefore seems advisable to reemphasize the dangers which may ensue and critically to reevaluate the ...
G, WILSON, C, RUPP, W W, WILSON
openaire +2 more sources
Physical Medicine and Rehabilitation Clinics of North America, 2018
Intrathecal baclofen therapy is a well-established technique for spasticity management. This article briefly reviews the pharmacology of intrathecal baclofen as well as customary approach for utilization of this targeted drug delivery concept. Following these descriptions, four unusual presentations will be described, including the need for initial ...
openaire +2 more sources
Intrathecal baclofen therapy is a well-established technique for spasticity management. This article briefly reviews the pharmacology of intrathecal baclofen as well as customary approach for utilization of this targeted drug delivery concept. Following these descriptions, four unusual presentations will be described, including the need for initial ...
openaire +2 more sources
Intrathecal Baclofen in Tetanus
Annals of the New York Academy of Sciences, 1986Our understanding of the pathogenesis of tetanus stems from the end of the nineteenth century. In 1884 the transfer of the infective as well as toxic agent of tetanus infection was demonstrated in animals [10, 50]. Only a few years later tetanus bacilli were isolated from human victims [44, 64] and its toxin was characterized as the pathogenic link [29]
H, Müller +3 more
openaire +3 more sources