Results 231 to 240 of about 74,181 (306)

SARS-CoV-2 Spike Peptides Trigger Nociceptive Responses Through Spinal TLR4 Pathways. [PDF]

Eur J Pain
Silva BE, Cardoso RR, Rosário LMR, Prado JP, Dos Santos RS, Veras FP, de Souza M, Cilli EM, Olivier D, de Andrade Belo MA, Charlie-Silva I, Caixeta ES, Barchuk AR, Nunes-Silva A, Romero TRL, Galdino G.   +15 more
europepmc   +1 more source

Choroid Plexus Microstructural Alterations Link Glymphatic Dysfunction and White Matter Degeneration in Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This study investigates the role of choroid plexus (CP) microstructural alterations in Parkinson's disease (PD), using free‐water corrected diffusion tensor imaging (FW‐DTI). Elevated CP diffusion metrics were linked to glymphatic dysfunction, corpus callosum degeneration, and worsened motor and cognitive performance in PD patients.
Suyi Zhou, Zhiming Zhen, Cheng Lai, Peiyu Huang, Zhe Sun, Taotao Yang, Fengwei Yu, Wei Chen, Zhentao Zuo, Wei Chen   +9 more
wiley   +1 more source

Phosphorylated Neurofilament Heavy Chain in Cerebrospinal Fluid and Serum as a Biomarker of Axonal Injury in Algerian Patients with Multiple Sclerosis. [PDF]

Diseases
Baiski BNEH, Mokrani Z, Atmani SM, Ider FZ, Lakri N, Souid FZ, Chaib S, Galleze A.   +7 more
europepmc   +1 more source

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Comments on "Low-Dose Morphine Intrathecal Analgesia in Elderly Patients with Hip Fracture Undergoing Single Spinal Anesthesia: A Randomized Controlled Trial" [Response to Letter]. [PDF]

Local Reg Anesth
Buršík D.
europepmc   +1 more source

Crosstalk Between Cortical Plasticity and Peripheral Nervous Injury: Insights, Mechanisms, and Future Directions

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Peripheral nerve injury induces dynamic cortical plasticity, driven by molecular mechanisms such as BDNF and neurotransmitter systems. This review synthesizes subtype‐specific plasticity patterns: compressive injuries trigger rapid reorganization, while metabolic neuropathies lead to maladaptive changes.
Cong Cheng, Dong Gao, Yaojie Shen, Xi Wang, Junxi Dai, Yaoxian Xiang, Zongyuan Jiang, Zongqi You, Junjian Jiang   +8 more
wiley   +1 more source

The Effectiveness Based on Optimal Dose and Administration Route, and Safety Profiles of Stem Cells and Derived Products in the Treatment of Patients With Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis. [PDF]

Stem Cells Int
Pourasghari M, Babaie S, Markazi-Movaghar R, Salehpour S, Eftekharsadat B, Farshbaf-Khalili A.   +5 more
europepmc   +1 more source

NG2‐Glia in Central Nervous System Following Injury: From Pathological Involvement to Repair Potential

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Following CNS injury, NG2‐glia display distinct functional phases. In the early stage, NG2‐glia are rapidly activated, proliferate, migrate to the lesion site and secrete CSPGs, which form a chemical and physical barrier that inhibits axonal regeneration.
Yunyun Cai, Xin Shen, Ming Li, Junjie Li, Gang Chen   +4 more
wiley   +1 more source

Estimation of human brain fluid clearance using intrathecal imaging contrast agents. [PDF]

Fluids Barriers CNS
Eide PK, Lashkarivand A, Hernes SS, Ringstad G, Hovd M.   +4 more
europepmc   +1 more source

Cancer‐related pain: A bidirectional modulator of cancer progression

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He, Yu Zhang, Qian Liu, Biao Yan, Peiwei Chai, Renbing Jia   +5 more
wiley   +1 more source