Results 21 to 30 of about 158,913 (343)

Successful Treatment of Isolated Central Nervous System Relapse with Intrathecal Chemotherapy in an Adolescent with Acute Promyelocytic Leukemia

Clinical Pediatric Hematology-Oncology, 2022
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) characterized by translocation of chromosomes 15 and 17 (t(15;17)), which rarely occurs in the pediatric population.
Haerim Song, Eun Sang Yi
doaj   +1 more source

Intra-Arterial, but Not Intrathecal, Baclofen and Codeine Attenuates Cough in the Cat

Frontiers in Physiology, 2021
Centrally-acting antitussive drugs are thought to act solely in the brainstem. However, the role of the spinal cord in the mechanism of action of these drugs is unknown.
Wendy L. Olsen, Melanie Rose, Frank J. Golder, Cheng Wang, Julie C. Hammond, Donald C. Bolser   +5 more
doaj   +1 more source

A comparative study of the effect of clonidine, fentanyl, and the combination of both as adjuvant to intrathecal bupivacaine for postoperative analgesia in total abdominal hysterectomy

Journal of Anaesthesiology Clinical Pharmacology, 2017
Background and Aims: The aim of this study was to evaluate the level of sensory block, onset and duration of motor block, postoperative analgesia, and adverse effects of combination of clonidine and fentanyl given intrathecally with hyperbaric ...
Fareed Ahmed, Mamta Khandelwal, Anil Sharma   +2 more
doaj   +1 more source

Comparative efficacy and safety of intrathecal ropivacaine versus intrathecal bupivacaine in patients undergoing lower abdominal surgical procedures

Indian Journal of Pain, 2020
Objective: The objective of the study was to compare the efficacy and safety of intrathecal ropivacaine versus intrathecal bupivacaine as anesthetic agents in patients undergoing lower abdominal surgeries.
Prasenjit Adhikari, Varsha Vyas, Shahbaz Naseem, Ulpesh Shelke   +3 more
doaj   +1 more source

Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. [PDF]

, 2016
Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silencing or upregulation in the central nervous system has been limited by the inability to provide more than limited deep parenchymal expression in adult ...
Ahrens, Eric T, Ciacci, Joseph, Cleveland, Don, Curtis, Erik, Gabel, Brandon, Hruska-Plochan, Marian, Juhas, Stefan, Juhasova, Jana, Kamizato, Kota, Kaspar, Brian K, Lukacova, Nada, Marsala, Martin, Marsala, Silvia, Miyanohara, Atsushi, Navarro, Michael   +14 more
core   +3 more sources

Optimum imaging and diagnosis of cerebrospinal fluid rhinorrhoea [PDF]

, 2000
Imaging is an important component in the investigation of unilateral watery rhinorrhoea suspicious of cerebrospinal fluid (CSF). Whilst the demonstration of the presence of beta 2 transferrin confirms that CSF is present it may prove difficult to ...
Howard, D, Lloyd, G, Lund, VJ, Savy, L
core   +1 more source

The role of spinal adrenergic receptors on the antinociception of ginsenosides in a rat postoperative pain model [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundThe effect of spinal adrenergic and cholinergic receptors on the anti-nociceptive effect of intrathecal ginsenosides was determined in a rat postoperative pain model.MethodsCatheters were placed into the intrathecal space of male Sprague-Dawley
In Ji Kim, Cheon Hee Park, Seong Heon Lee, Myung Ha Yoon   +3 more
doaj   +1 more source

Stage progression and neurological symptoms in Trypanosoma brucei rhodesiense sleeping sickness: role of the CNS inflammatory response [PDF]

, 2012
Background: Human African trypanosomiasis progresses from an early (hemolymphatic) stage, through CNS invasion to the late (meningoencephalitic) stage.
A Hainard, B Beutler, B Courtioux, B Namangala, CA Hunter, CA Hunter, CF Calvo, EN Benveniste, F Checchi, F Esamai, G Binz, H Reiber, H Reiber, H Reiber, Hansotto Reiber, HY Hassan, J Kabore, J Rodgers, Jeremy M. Sternberg, JM Sternberg, JM Sternberg, JM Sternberg, Joseph Mathu Ndung'u, KW Moore, L Maclean, L MacLean, L MacLean, L MacLean, LJ Morrison, LM MacLean, Lorna MacLean, M Sjogren, MC Okomo-Assoumou, P Cattand, PD Eckersall, Peter G. E. Kennedy, PG Kennedy, PGE Kennedy, PGE Kennedy, TN Baral, V Jamonneau, V Lejon, V Lejon, V Lejon, W Masocha   +44 more
core   +4 more sources

First-in-Man Intrathecal Application of Neurite Growth-Promoting Anti-Nogo-A Antibodies in Acute Spinal Cord Injury

Neurorehabilitation and Neural Repair, 2018
Background. Neutralization of central nervous system neurite growth inhibitory factors, for example, Nogo-A, is a promising approach to improving recovery following spinal cord injury (SCI).
K. Kucher, Donald R. Johns, D. Maier, R. Abel, A. Badke, H. Baron, R. Thietje, S. Casha, R. Meindl, B. Gomez-Mancilla, Christian U Pfister, R. Rupp, N. Weidner, A. Mir, M. Schwab, A. Curt   +15 more
semanticscholar   +1 more source

Intrathecal 99mTc‐DTPA imaging of molecular passage from lumbar cerebrospinal fluid to brain and periphery in humans

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Cerebrospinal fluid (CSF) molecular exchange with brain interstitial fluid (ISF) and periphery is implicated in neurological disorders but needs better quantitative clinical assessment approaches.
Ajay Verma, Jacob Y. Hesterman, J. Levi Chazen, Robert Holt, Patrick Connolly, Laura Horky, Shankar Vallabhajosula, P. David Mozley   +7 more
doaj   +1 more source