Results 121 to 130 of about 2,160,956 (299)
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
, 2019 Shaded areas (red = intrinsic disorder; blue = amyloid-like cross-beta strand) denote sequence regions predicted as positive by each cohort of algorithms.
Gaurav Jain (68164) +2 more
core +1 more source
Analysis of a Nuclear Intrinsically Disordered Proteome
, 2020 Intrinsically disordered proteins (IDPs) play crucial roles in cell functioning, although they do not possess defined three-dimensional architecture. They are highly abundant in the cell nucleus, and the vast majority of transcription factors (TFs) contain extended regions of intrinsic disorder.
Skupień-Rabian, Bożena +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
A collection of intrinsic disorder characterizations from eukaryotic proteomes
, 2016 This is a sqlite3 file containing intrinsic disorder characterizations from ten eukaryotic proteomes. For detailed information regarding the content and the database schema, please refer to Vincent and Schnell ...
Santiago Schnell (196699) +1 more
core +1 more source
Functions of Intrinsically Disordered Regions
BiologyIntrinsically disordered regions (IDRs), defined as protein segments lacking stable tertiary structures, are ubiquitously present in the human proteome and enriched with disease-associated mutations. IDRs harbor molecular recognition features (MoRFs) and post-translational modification sites (e.g., phosphorylation), enabling dynamic intermolecular ...
Linhu Xiao, Kun Xia
openaire +3 more sources
Frontiers in Plant Science, 2015 Fungal plant pathogens produce secreted proteins adapted to function outside fungal cells to facilitate colonization of their hosts. In many cases such as for fungi from the Sclerotiniaceae family the repertoire and function of secreted proteins remains ...
Thomas eBadet +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
More Than Just Tails: Intrinsic Disorder in Histone Proteins
, 2012 Many biologically active proteins are disordered as a whole, or contain long disordered regions. These intrinsically disordered proteins/regions are very common in nature, abundantly found in all organisms, where they carry out important biological ...
Kurgan, Lukasz +4 more
core +1 more source
eLife, 2019 Most motile flagella have an axoneme that contains nine outer microtubule doublets and a central pair (CP) of microtubules. The CP coordinates the flagellar beat and defects in CP projections are associated with motility defects and human disease. The CP
Samuel Dean +2 more
doaj +1 more source