Results 81 to 90 of about 2,160,956 (299)

Assessment of Disordered Linker Predictions in the CAID2 Experiment

Biomolecules
Disordered linkers (DLs) are intrinsically disordered regions that facilitate movement between adjacent functional regions/domains, contributing to many key cellular functions.
Kui Wang, Gang Hu, Zhonghua Wu, Vladimir N. Uversky, Lukasz Kurgan   +4 more
doaj   +1 more source

GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity

Frontiers in Cell and Developmental Biology, 2021
Intravascular processing of triglyceride-rich lipoproteins (TRLs) is crucial for delivery of dietary lipids fueling energy metabolism in heart and skeletal muscle and for storage in white adipose tissue.
Kristian Kølby Kristensen, Kristian Kølby Kristensen, Katrine Zinck Leth-Espensen, Katrine Zinck Leth-Espensen, Anni Kumari, Anni Kumari, Anne Louise Grønnemose, Anne Louise Grønnemose, Anne-Marie Lund-Winther, Anne-Marie Lund-Winther, Stephen G. Young, Stephen G. Young, Michael Ploug, Michael Ploug   +13 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Intrinsic Disorder in Tetratricopeptide Repeat Proteins

, 2020
Among the realm of repeat containing proteins that commonly serve as “scaffolds” promoting protein-protein interactions, there is a family of proteins containing between 2 and 20 tetratricopeptide repeats (TPRs), which are functional motifs ...
Roy Khalife, Cornelia Haerle, Khalifa, Roy, Uversky, Vladimir N., Bibber, Nathan W., Bin Xue, Nathan W. Van Bibber, Vladimir N. Uversky, Xue, Bin, Haerle, Cornelia   +9 more
core   +1 more source

A Set of Interaction Potentials for Molecular Dynamics Simulations of YPO₄ Crystal

Crystals
A set of empirical pair interaction potentials for molecular dynamics (MD) modeling of the YPO4 crystal is proposed. The parameters of the potentials, as well as the effective charges of the ions, are recovered based on experimental data on the lattice ...
Kirill A. Nekrasov, Yulia A. Kuznetsova, Dmitry V. Raikov, Vyacheslav V. Pchelnikov   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Histogram of predicted intrinsic disorder in 2,278 viral genomes.

, 2013
Histogram of predicted intrinsic disorder in 2,278 viral genomes.
Norman E. Davey (18563), Denis C. Shields (18564), Ravindra Pushker (56005), Jean-Marc Jacqué (404840), Catherine Mooney (76525)   +4 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Evolutionary Conservation of Intrinsic Protein Disorder.

, 2016
A) Disorder conservation prediction of Twist1 proteins. The disorder feature found in the N-terminus region of Twist1 is evolutionary conserved. B) Disorder conservation prediction of Twist2 proteins.
Carmen L. Cadilla (160681), Yacidzohara Rodriguez (3074568), Ricardo R. Gonzalez-Mendez (3074565)   +2 more
core   +1 more source

Conformational Recognition of an Intrinsically Disordered Protein [PDF]

Biophysical Journal, 2014
There is a growing interest in understanding the properties of intrinsically disordered proteins (IDPs); however, the characterization of these states remains an open challenge. IDPs appear to have functional roles that diverge from those of folded proteins and revolve around their ability to act as hubs for protein-protein interactions.
Krieger J. M., Fusco G., Lewitzky M., Simister P. C., Marchant J., Camilloni C., Feller S. M., De Simone A.   +7 more
openaire   +3 more sources