Results 81 to 90 of about 156,443 (294)

Assessment of Disordered Linker Predictions in the CAID2 Experiment

Biomolecules
Disordered linkers (DLs) are intrinsically disordered regions that facilitate movement between adjacent functional regions/domains, contributing to many key cellular functions.
Kui Wang, Gang Hu, Zhonghua Wu, Vladimir N. Uversky, Lukasz Kurgan   +4 more
doaj   +1 more source

GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity

Frontiers in Cell and Developmental Biology, 2021
Intravascular processing of triglyceride-rich lipoproteins (TRLs) is crucial for delivery of dietary lipids fueling energy metabolism in heart and skeletal muscle and for storage in white adipose tissue.
Kristian Kølby Kristensen, Kristian Kølby Kristensen, Katrine Zinck Leth-Espensen, Katrine Zinck Leth-Espensen, Anni Kumari, Anni Kumari, Anne Louise Grønnemose, Anne Louise Grønnemose, Anne-Marie Lund-Winther, Anne-Marie Lund-Winther, Stephen G. Young, Stephen G. Young, Michael Ploug, Michael Ploug   +13 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Intrinsic Disorder and Semi-disorder Prediction by SPINE-D

, 2016
Over the past decade, it has become evident that a large proportion of proteins contain intrinsically disordered regions, which play important roles in pivotal cellular functions.
Zhang, Tuo, Faraggi, Eshel, Li, Zhixiu, Eshel Faraggi, Zhou, Yaoqi, Yaoqi Zhou, Tuo Zhang, Zhixiu Li   +7 more
core   +1 more source

A Set of Interaction Potentials for Molecular Dynamics Simulations of YPO₄ Crystal

Crystals
A set of empirical pair interaction potentials for molecular dynamics (MD) modeling of the YPO4 crystal is proposed. The parameters of the potentials, as well as the effective charges of the ions, are recovered based on experimental data on the lattice ...
Kirill A. Nekrasov, Yulia A. Kuznetsova, Dmitry V. Raikov, Vyacheslav V. Pchelnikov   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

How Disordered are neurodevelopmental disorders? (The involvement of intrinsically disordered proteins in neurodevelopmental disorders)

, 2022
reservedDespite that as much as 15 percent of the population develop neurodevelopmental disorders, still little is known about the truncated cellular processes potentially caused by structural modifications in the proteins.
KORDEVANI, FATEMEH
core  

Intrinsic Disorder of the Neuronal SNARE Protein SNAP25a in its Pre-fusion Conformation

, 2022
The neuronal Q-SNARE protein SNAP25a (isoform 2) forms part of the SNARE complex eliciting synaptic vesicle fusion during neuronal exocytosis. While the post-fusion cis-SNARE complex has been studied extensively, little is known about the pre-fusion ...
Sonja, Sonja Pribicevic, Nils-Alexander, Lakomek, Reinhard, Jahn, Lothar, Gremer, Tobias, Stief, Angel, Perez-Lara   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source