Results 151 to 160 of about 44,790 (294)

Kidney Structure and Blood Flow Predict Function and Enable Image‐Based eGFR With Non‐Contrast MRI

open access: yesNMR in Biomedicine, Volume 39, Issue 10, October 2026.
Multiparametric renal MRI in healthy adults identified cortical thickness (r² = 0.38) and renal blood flow (r² = 0.29; both p < 0.001) as the strongest predictors of creatinine‐based eGFR. Together, these measures explained 47% of eGFR variability. Prospective validation demonstrated low bias (−4.9 to 3.4 mL/min/1.73 m²) and good accuracy (p30: 87%–92%)
Emily Powell   +5 more
wiley   +1 more source

Development, Early Verification and Application of a North American Pediatric PBPK Model, Comparison With the North European Pediatric Population

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) models are increasingly used in pediatric drug development and matching such models to the target population is an important consideration. A US pediatric PBPK model was developed incorporating four sub‐groups describing physiology and enzymatic/transporter levels for White, African American ...
Trevor N. Johnson   +5 more
wiley   +1 more source

Bile Acid Metabolism as a Unifying Readout for Diet, Microbiome Function, and Gastrointestinal Disease

open access: yesThe FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Dietary components shape the gut microbiome, which modifies bile acids through transformations. The resulting bile acid pool is sensed by host receptors to regulate immunity, metabolism, and intestinal function. Targeted bile acid measurements provide a unifying readout to study diet‐microbiome interactions and to develop next‐generation dietary ...
Jason Dichter
wiley   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

open access: yesAdvanced Science, Volume 13, Issue 52, 18 September 2026.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang   +17 more
wiley   +1 more source

Designing Tissue Function Through Embedded Bioprinting Architectures

open access: yesAdvanced Science, Volume 13, Issue 52, 18 September 2026.
Embedded bioprinting enables soft, cell‐dense constructs to be fabricated within supporting bath environments. This review introduces a function‐guided framework linking target tissue functions to architectural requirements, supporting bath selection, bioink design, printing dynamics, and validation assays.
Qi Li   +4 more
wiley   +1 more source

Sustainable levulinic acid production from inulin via hydrothermal conversion

open access: yesBiofuels, Bioproducts and Biorefining, Volume 20, Issue 5, Page 2068-2081, September/October 2026.
Abstract This study investigates the hydrothermal conversion of inulin using potassium pyrosulfate to levulinic acid (LA). The Box–Behnken design approach was applied to optimize the conversion parameters and analyze the interactions influencing LA yield.
Gwi‐Taek Jeong
wiley   +1 more source

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