Results 31 to 40 of about 100,331 (293)
Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions. [PDF]
PLoS Biology, 2013 Pentameric ligand-gated ion channels (pLGICs) are neurotransmitter-activated receptors that mediate fast synaptic transmission. In pLGICs, binding of agonist to the extracellular domain triggers a structural rearrangement that leads to the opening of an ...
Cosma D Dellisanti +9 more
doaj +1 more source
Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating
Scientific Reports, 2017 AMPA subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission and are implicated in numerous neurological diseases. Ionic currents through AMPA receptor channels can be allosterically regulated via different sites on the receptor ...
Maria V. Yelshanskaya +3 more
doaj +1 more source
Optical control of PIEZO1 channels
Nature Communications, 2023 PIEZO proteins are large, mechanically-activated trimeric ion channels. Here the authors report a light-gated mouse PIEZO1 channel, mOP1, whereby an azobenzene-based photoswitch covalently localised at the extracellular apex of a transmembrane helix ...
Francisco Andrés Peralta +8 more
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Hydrophobic Gating in Ion Channels
Journal of Molecular Biology, 2015 Biological ion channels are nanoscale transmembrane pores. When water and ions are enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit behavior not evident from macroscopic descriptions. At this nanoscopic level, the unfavorable interaction between the lining of a hydrophobic pore and water may lead to stochastic ...
Aryal, P, Sansom, MS, Tucker, S
openaire +3 more sources
A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems
Nature Communications, 2018 Uptake and release of glucose is regulated by glucose-sensitive ion channels, but complexity of the system impedes investigation of the gating behavior under physiological conditions.
Yue Sun +9 more
doaj +1 more source
Biophysical Effects Of Ion Concenteration On The Affinity Between Nanopore, OmpF Lumen and Passing Nucleotide [PDF]
, 2010 OmpF an outer-membrane porin channel of _E. Coli_ posses beta-barrel structure, whose conductivity and gating phenomena are affected by changes in pH, salt concentration and so on. The distribution of amino acids in OmpF induces a non homologous electric
Hamid Mobasheri, Saeid Hadi
core +2 more sources
Multiple solutions of steady-state Poisson-Nernst-Planck equations with steric effects
, 2014 Experiments measuring currents through single protein channels show unstable currents. Channels switch between 'open' or 'closed' states in a spontaneous stochastic process called gating.
Eisenberg, Bob, Lin, Tai-Chia
core +1 more source
Proton block of proton-activated TRPV1 current. [PDF]
, 2015 The TRPV1 cation channel is a polymodal nociceptor that is activated by heat and ligands such as capsaicin and is highly sensitive to changes in extracellular pH. In the body core, where temperature is usually stable and capsaicin is normally absent, H(+)
Lee, Bo Hyun, Zheng, Jie
core +1 more source
Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel
eLife, 2012 The gating ring-forming RCK domain regulates channel gating in response to various cellular chemical stimuli in eukaryotic Slo channel families and the majority of ligand-gated prokaryotic K+ channels and transporters.
Chunguang Kong +7 more
doaj +1 more source
A binding-block ion selective mechanism revealed by a Na/K selective channel
Protein & Cell, 2017 Mechanosensitive (MS) channels are extensively studied membrane protein for maintaining intracellular homeostasis through translocating solutes and ions across the membrane, but its mechanisms of channel gating and ion selectivity are largely unknown ...
Jie Yu +9 more
doaj +1 more source