Results 31 to 40 of about 4,654,285 (364)

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

British Journal of Pharmacology, 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where ...
Stephen P. H. Alexander, A. Mathie, J. A. Peters, E. Veale, J. Striessnig, E. Kelly, J. Armstrong, E. Faccenda, S. Harding, Adam J Pawson, J. Sharman, C. Southan, J. Davies   +12 more
semanticscholar   +1 more source

Ion channels [PDF]

BMJ, 1997
Ion channels are protein pores in the cell membrane that allow the passage of ions down their respective electrochemical gradients.1 The ubiquitous presence of ion channels among cells of unicellular and multicellular organisms suggests their importance in maintaining cellular integrity. Our understanding of the part that they play in disease has grown
Paul D. Abel, El-Nasir Lalani, Marc Laniado   +2 more
openaire   +3 more sources

Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression

Cells, 2021
The transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer.
Gonçalo Mesquita, Natalia Prevarskaya, Albrecht Schwab, V’yacheslav Lehen’kyi   +3 more
doaj   +1 more source

Role of ion channels in gastrointestinal cancer

World Journal of Gastroenterology, 2019
In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer cell. The functions of ion channels in the gastrointestinal (GI) tract influence a variety of cellular processes, many of ...
Kyle J Anderson, R. Cormier, P. Scott
semanticscholar   +1 more source

A TR(i)P to Cell Migration: New Roles of TRP Channels in Mechanotransduction and Cancer

Frontiers in Physiology, 2019
Cell migration is a key process in cancer metastasis, allowing malignant cells to spread from the primary tumor to distant organs. At the molecular level, migration is the result of several coordinated events involving mechanical forces and cellular ...
Jimena Canales, Jimena Canales, Diego Morales, Diego Morales, Constanza Blanco, Constanza Blanco, José Rivas, José Rivas, Nicolás Díaz, Nicolás Díaz, Ioannis Angelopoulos, Ioannis Angelopoulos, Oscar Cerda, Oscar Cerda, Oscar Cerda   +14 more
doaj   +1 more source

OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

bioRxiv, 2018
Mechanotransduction, the conversion of mechanical cues into biochemical signals, is crucial for many biological processes in plants and animals1,2. In mammals, some mechanosensory processes such as touch sensation and vascular development are mediated by
Swetha E. Murthy, A. Dubin, Tess Whitwam, S. Jojoa-Cruz, Stuart M. Cahalan, S. Mosavi, A. Ward, A. Patapoutian   +7 more
semanticscholar   +1 more source

Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis

Cells, 2020
It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells.
Aurélien Haustrate, Natalia Prevarskaya, V’yacheslav Lehen’kyi   +2 more
doaj   +1 more source

Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels

Cells, 2021
Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover, mitochondria are involved in cardiac ischemia/reperfusion injury by opening the mitochondrial permeability transition pore which is the major cause of cell death.
Bogusz Kulawiak, Piotr Bednarczyk, Adam Szewczyk   +2 more
doaj   +1 more source

Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?

Physiological Reviews, 2018
Genomic instability is a primary cause and fundamental feature of human cancer. However, all cancer cell genotypes generally translate into several common pathophysiological features, often referred to as cancer hallmarks.
N. Prevarskaya, R. Skryma, Y. Shuba
semanticscholar   +1 more source

Machine learning-assisted genomic profiling to identify differences between Bacillus Calmette-Guérin (BCG) vaccine strains and non-BCG wild-type Mycobacterium bovis [PDF]

PeerJ Computer Science
Background Distinguishing Bacillus Calmette-Guérin (BCG) vaccines from pathogenic Mycobacterium bovis is critical in neonatal diagnostics, particularly where polymerase chain reaction (PCR) methods fail to detect key genomic variations in tuberculosis ...
Yunyun Shi, Jiang Yuan, Xiaobin Tang, Hai Luo, Genyun Tang, Zhiyong Shen   +5 more
doaj   +2 more sources