Results 51 to 60 of about 4,654,285 (364)
Molecules, 2020 Naringenin, a flavanone obtained from citrus fruits and present in many traditional Chinese herbal medicines, has been shown to have various beneficial effects on cells both in vitro and in vivo.
Anna Kicinska +6 more
doaj +1 more source
Scentsational Ion Channels [PDF]
Neuron, 1996 Finally, but perhaps most enticing, Coburn and Bargmann also observed striking defects in the growth of sensory axons in tax-2 and tax-4 mutants. The defects were primarily expressed as an overgrowth of axonal processes, with subsets of sensory neurons displaying either inappropriate additional axonal branches or a failure to terminate upon reaching ...
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Functional correlates of clinical phenotype and severity in recurrent SCN2A variants
Communications Biology, 2022 A comprehensive biophysical analysis of disease-associated mutations in the voltage-gated sodium channel gene, SCN2A, suggests that dynamic action potential clamp may be a better predictor than voltage clamp of how these mutations alter neuronal ...
Géza Berecki +15 more
doaj +1 more source
Ion Channel Reconstitution [PDF]
Biophysical Journal, 2012 Since the discovery of the possible solubilization of membrane proteins and their isolation from other membrane constituents (purification), different methods were developed to reconstitute ion channel proteins into artificial lipid bilayers. These membrane proteins were then fully functional when correctly oriented and inserted in a lipid bilayer. The
Andrea Brueggemann +3 more
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Fluorescent Probes to Image the KCa3.1 Channel in Tumor Cells
PharmaceuticsBackground/Objectives: The Ca2+-activated K+ channel KCa3.1 is not only involved in physiological processes such as immune reactions and control of vascular tone, but is highly expressed in various tumor entities.
Insa Thale +8 more
doaj +1 more source
Cannabinoid interactions with ion channels and receptors
Channels, 2019 Cannabidiol (CBD), the non-psychoactive component of Cannabis sativa, acts on a diverse selection of membrane proteins with promising therapeutic potential in epilepsy and chronic pain. One such protein is the voltage-gated sodium channel (Nav).
Abeline R. Watkins
semanticscholar +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Ion channels as therapeutic antibody targets
mAbs, 2018 It is now well established that antibodies have numerous potential benefits when developed as therapeutics. Here, we evaluate the technical challenges of raising antibodies to membrane-spanning proteins together with enabling technologies that may ...
C. J. Hutchings +2 more
semanticscholar +1 more source
Ion Channels in Glioblastoma [PDF]
ISRN Neurology, 2011 Glioblastoma is the most common primary brain tumor with the most dismal prognosis. It is characterized by extensive invasion, migration, and angiogenesis. Median survival is only 15 months due to this behavior, rendering focal surgical resection ineffective and adequate radiotherapy impossible. At this moment, several ion channels have been implicated
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FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source